Zobrazeno 1 - 10
of 21
pro vyhledávání: '"axon morphogenesis"'
Publikováno v:
Frontiers in Molecular Neuroscience, Vol 15 (2022)
Nexmif is mainly expressed in the central nervous system (CNS) and plays important roles in cell migration, cell to cell and cell-matrix adhesion, and maintains normal synaptic formation and function. Nevertheless, it is unclear how nexmif is linked
Externí odkaz:
https://doaj.org/article/e4077b833f634a7f9f37e319fd97040b
Publikováno v:
eLife, Vol 6 (2017)
The etiological underpinnings of amyotrophic lateral sclerosis (ALS) are complex and incompletely understood, although contributions to pathogenesis by regulators of proteolytic pathways have become increasingly apparent. Here, we present a novel var
Externí odkaz:
https://doaj.org/article/d56a80c9cd784894b56a22723e6abfe1
Autor:
Britta J. Eickholt, Michal Szczepek, Niclas Gimber, Julia Ledderose, Joachim Fuchs, Annika Brosig, Christian Rosenmund, Sandra Schrötter, Mayur Vadhvani, Christian M. T. Spahn, Ivo Lieberam, Hermann-Georg Holzhütter, Thorsten Trimbuch, Jan Schmoranzer, Michiel T. van Diepen, Alexandra Polyzou, George Leondaritis, Patrick Scheerer, Cristina Kroon, Fatih Ipek
Publikováno v:
Cell Reports, Vol 29, Iss 7, Pp 2028-2040.e8 (2019)
Cell Reports
Cell Reports
Summary In developing neurons, phosphoinositide 3-kinases (PI3Ks) control axon growth and branching by positively regulating PI3K/PI(3,4,5)P3, but how neurons are able to generate sufficient PI(3,4,5)P3 in the presence of high levels of the antagoniz
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3a4b559ef8b47b9c4f08dcfa66f51787
http://www.sciencedirect.com/science/article/pii/S2211124719313531
http://www.sciencedirect.com/science/article/pii/S2211124719313531
Publikováno v:
Neural Development, Vol 14, Iss 1, Pp 1-28 (2019)
Neural Development
Hahn, I, Voelzmann, A, Liew, Y T, Costa Gomes, B & Prokop, A 2019, ' The model of local axon homeostasis-explaining the role and regulation of microtubule bundles in axon maintenance and pathology ', Neural Development, vol. 14, no. 11, 10.1186/s13064-019-0134-0 . https://doi.org/10.1186/s13064-019-0134-0
Neural Development
Hahn, I, Voelzmann, A, Liew, Y T, Costa Gomes, B & Prokop, A 2019, ' The model of local axon homeostasis-explaining the role and regulation of microtubule bundles in axon maintenance and pathology ', Neural Development, vol. 14, no. 11, 10.1186/s13064-019-0134-0 . https://doi.org/10.1186/s13064-019-0134-0
Axons are the slender, cable-like, up to meter-long projections of neurons that electrically wire our brains and bodies. In spite of their challenging morphology, they usually need to be maintained for an organism's lifetime. This makes them key lesi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3888fa799dc945b2f630712a614cef51
http://link.springer.com/article/10.1186/s13064-019-0134-0
http://link.springer.com/article/10.1186/s13064-019-0134-0
Publikováno v:
Frontiers in Neuroscience, Vol 15 (2021)
Frontiers in Neuroscience
Frontiers in Neuroscience
Growth cones at the tips of extending axons navigate through developing organisms by probing extracellular cues, which guide them through intermediate steps and onto final synaptic target sites. Widespread focus on a few guidance cue families has his
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d4f24d77a87027b60a140411fc255e4e
Akademický článek
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Akademický článek
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Publikováno v:
eLife, Vol 6 (2017)
Amyotrophic lateral sclerosis, or ALS for short, is a disease in which parts of the brain and spinal cord progressively degenerate. Specifically, the condition causes the nerve cells that control movement – called motor neurons – to die. As a res
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::60b9e5d70a576d766d3693323481d32e
https://elifesciences.org/articles/25453
https://elifesciences.org/articles/25453