Zobrazeno 1 - 10
of 777
pro vyhledávání: '"autoreactive T cells"'
Autor:
Stefano Angiari, Tommaso Carlucci, Simona L. Budui, Simone D. Bach, Silvia Dusi, Julia Walter, Elena Ellmeier, Alyssa Schnabl, Anika Stracke, Natalie Bordag, Cansu Tafrali, Rina Demjaha, Michael Khalil, Gabriele Angelini, Eleonora Terrabuio, Enrica C. Pietronigro, Elena Zenaro, Carlo Laudanna, Barbara Rossi, Gabriela Constantin
Publikováno v:
Journal of Neuroinflammation, Vol 21, Iss 1, Pp 1-20 (2024)
Abstract Background Immune cell metabolism governs the outcome of immune responses and contributes to the development of autoimmunity by controlling lymphocyte pathogenic potential. In this study, we evaluated the metabolic profile of myelin-specific
Externí odkaz:
https://doaj.org/article/19bcace4f9534713941eafecd1fb424a
Autor:
Gagandeep Kaur, Eun‐Hye Bae, Yu Zhang, Nicole Ciacciofera, Kyung Min Jung, Heather Barreda, Carol Paleti, Joo Youn Oh, Ryang Hwa Lee
Publikováno v:
Journal of Extracellular Vesicles, Vol 13, Iss 8, Pp n/a-n/a (2024)
Abstract Extracellular vesicles (EVs) derived from mesenchymal stem/stromal cells (MSCs) have been recognized as promising cytotherapeutics due to their demonstrated immunomodulatory effects in various preclinical models. The immunomodulatory capabil
Externí odkaz:
https://doaj.org/article/b2af8e91211e43c38a500c8e5f7cf138
Autor:
Hisato Iriki, Miho Mukai, Yasuhiko Asahina, Yoko Kubo, Hiromi Ito, Masayuki Amagai, Hayato Takahashi
Publikováno v:
Immunity & Ageing, Vol 20, Iss 1, Pp 1-7 (2023)
Abstract Various autoimmune responses increase with age, but the underlying mechanism is not clear. In this study, we used CD4+ T cells expressing a transgenic T cell receptor specific for desmoglein 3 (Dsg3), which is the target antigen of the autoi
Externí odkaz:
https://doaj.org/article/f0c8d2c8aab247a797a9334962683d0b
Akademický článek
Tento výsledek nelze pro nepřihlášené uživatele zobrazit.
K zobrazení výsledku je třeba se přihlásit.
K zobrazení výsledku je třeba se přihlásit.
Akademický článek
Tento výsledek nelze pro nepřihlášené uživatele zobrazit.
K zobrazení výsledku je třeba se přihlásit.
K zobrazení výsledku je třeba se přihlásit.
Akademický článek
Tento výsledek nelze pro nepřihlášené uživatele zobrazit.
K zobrazení výsledku je třeba se přihlásit.
K zobrazení výsledku je třeba se přihlásit.
Autor:
Fariza Mishaal Saiema Badloe, Shauni De Vriese, Katarina Coolens, Carsten B. Schmidt-Weber, Johannes Ring, Jan Gutermuth, Inge Kortekaas Krohn
Publikováno v:
Clinical and Translational Allergy, Vol 10, Iss 1, Pp 1-15 (2020)
Abstract The pathophysiology of atopic dermatitis (AD) is highly complex and understanding of disease endotypes may improve disease management. Immunoglobulins E (IgE) against human skin epitopes (IgE autoantibodies) are thought to play a role in dis
Externí odkaz:
https://doaj.org/article/1e1a027888f44d36b09bd26bb1a1c639
Autor:
Irina A. Ishina, Maria Y. Zakharova, Inna N. Kurbatskaia, Azad E. Mamedov, Alexey A. Belogurov, Alexander G. Gabibov
Publikováno v:
Cells, Vol 12, Iss 2, p 314 (2023)
Antigen presentation by major histocompatibility complex class II (MHC-II) molecules is crucial for eliciting an efficient immune response by CD4+ T cells and maintaining self-antigen tolerance. Some MHC-II alleles are known to be positively or negat
Externí odkaz:
https://doaj.org/article/6fc51c7d5a7b4982881a0387e9119871
Autor:
Teresa Rodriguez-Calvo, Gustaf Christoffersson, Christine Bender, Matthias G. von Herrath, Roberto Mallone, Sally C. Kent, Eddie A. James
Publikováno v:
Frontiers in Immunology, Vol 12 (2021)
In human type 1 diabetes and animal models of the disease, a diverse assortment of immune cells infiltrates the pancreatic islets. CD8+ T cells are well represented within infiltrates and HLA multimer staining of pancreas sections provides clear evid
Externí odkaz:
https://doaj.org/article/8ebd83c47ba24d9f92464ec043f3b06e
Publikováno v:
Stem Cell Research & Therapy, Vol 10, Iss 1, Pp 1-10 (2019)
Abstract Background Type 1 diabetes (T1D) is an autoimmune disease resulting from the destruction of insulin-secreting islet β cells by autoreactive T cells. Non-obese diabetic (NOD) mice are the widely used animal model for human T1D. Autoimmunity
Externí odkaz:
https://doaj.org/article/6bb5b1d2b7694c848430bdb4f9f13d17