Zobrazeno 1 - 10
of 105
pro vyhledávání: '"autophagy dysfunction"'
Autor:
Mengqi Hao, Jianjian Chu, Tinglin Zhang, Tong Yin, Yuankai Gu, Wendanqi Liang, Wenbo Ji, Jianhua Zhuang, Yan Liu, Jie Gao, You Yin
Publikováno v:
Neural Regeneration Research, Vol 20, Iss 2, Pp 424-439 (2025)
Alzheimer’s disease is a debilitating, progressive neurodegenerative disorder characterized by the progressive accumulation of abnormal proteins, including amyloid plaques and intracellular tau tangles, primarily within the brain. Lysosomes, crucia
Externí odkaz:
https://doaj.org/article/ac085bdba31440ecb8718abac96efc38
Publikováno v:
Particle and Fibre Toxicology, Vol 21, Iss 1, Pp 1-27 (2024)
Abstract Background Zinc oxide nanoparticles (ZnONPs) are common materials used in skin-related cosmetics and sunscreen products due to their whitening and strong UV light absorption properties. Although the protective effects of ZnONPs against UV li
Externí odkaz:
https://doaj.org/article/dce8813106df4cfb84d5f6425cb98f9e
Autor:
Chih Hung Lo, Jialiu Zeng
Publikováno v:
Translational Neurodegeneration, Vol 12, Iss 1, Pp 1-11 (2023)
Abstract Lysosomal acidification dysfunction has been implicated as a key driving factor in the pathogenesis of neurodegenerative diseases, including Alzheimer’s disease and Parkinson’s disease. Multiple genetic factors have been linked to lysoso
Externí odkaz:
https://doaj.org/article/aa266ef21cc34217b4ed526a56272f84
Publikováno v:
Frontiers in Physiology, Vol 14 (2023)
Objective: This study clarified the risk factors and pathophysiology of pancreatic cancer by examining the factors associated with fatty pancreas.Methods: The degree of fatty pancreas, background factors, and incidence of pancreatic cancer were exami
Externí odkaz:
https://doaj.org/article/9d57503e43ed47a28dadb903db59b1f6
Akademický článek
Tento výsledek nelze pro nepřihlášené uživatele zobrazit.
K zobrazení výsledku je třeba se přihlásit.
K zobrazení výsledku je třeba se přihlásit.
Publikováno v:
Ecotoxicology and Environmental Safety, Vol 257, Iss , Pp 114947- (2023)
Due to the rapid production growth and a wide range of applications, safety concerns are being raised about the genotoxic properties of silver nanoparticles (AgNPs). In this research, we found AgNPs induced a size-dependent genotoxicity via lysosomal
Externí odkaz:
https://doaj.org/article/a6768c73e48d499dbeb8054c7cdd9a20
Akademický článek
Tento výsledek nelze pro nepřihlášené uživatele zobrazit.
K zobrazení výsledku je třeba se přihlásit.
K zobrazení výsledku je třeba se přihlásit.
Autor:
Mingxiang Wang, Jin Li, Shunni Dong, Xiaobo Cai, Aili Simaiti, Xin Yang, Xinqiang Zhu, Jianhong Luo, Lin-Hua Jiang, Binyang Du, Peilin Yu, Wei Yang
Publikováno v:
Particle and Fibre Toxicology, Vol 17, Iss 1, Pp 1-22 (2020)
Abstract Background Wide applications of nanoparticles (NPs) have raised increasing concerns about safety to humans. Oxidative stress and inflammation are extensively investigated as mechanisms for NPs-induced toxicity. Autophagy and lysosomal dysfun
Externí odkaz:
https://doaj.org/article/b5bde777a19440c1bb832dab56f5a5b0
Autor:
Yuexiao Ma, Qingqing Liang, Fenghong Wang, Kanglin Yan, Mengqi Sun, Lisen Lin, Tianyu Li, Junchao Duan, Zhiwei Sun
Publikováno v:
Ecotoxicology and Environmental Safety, Vol 232, Iss , Pp 113303- (2022)
It has been reported that silica nanoparticles (SiNPs) could cause epithelial-to-mesenchymal transition (EMT), but the specific mechanism is still unclear. Thus, the purpose of this study was to investigate the underlying mechanisms of pulmonary EMT
Externí odkaz:
https://doaj.org/article/66bd2675c18a480eafa91ab1d5d26a2d
Publikováno v:
Frontiers in Neuroscience, Vol 15 (2021)
Ischemic stroke is a leading cause of death worldwide; currently available treatment approaches for ischemic stroke are to restore blood flow, which reduce disability but are time limited. The interruption of blood flow in ischemic stroke contributes
Externí odkaz:
https://doaj.org/article/31c74cd223d44fbb8934e44ed09da5c1