Zobrazeno 1 - 10
of 7 155
pro vyhledávání: '"autophagosome"'
Autor:
Qiaohui Shen, Ming Yang, Song Wang, Xingyu Chen, Sulan Chen, Rui Zhang, Zhuang Xiong, Yan Leng
Publikováno v:
Frontiers in Endocrinology, Vol 15 (2024)
Non-alcoholic fatty liver disease (NAFLD) is a clinicopathologic syndrome characterized by excessive fat deposition in hepatocytes and a major cause of end-stage liver disease. Autophagy is a metabolic pathway responsible for degrading cytoplasmic pr
Externí odkaz:
https://doaj.org/article/53d6342e67de4bf48fbe8aba0729cbf2
Publikováno v:
Turkish Journal of Hematology, Vol 41, Iss 1, Pp 16-25 (2024)
Objective: Multiple myeloma, which affects plasma cells, is the second most common hematological malignancy. Despite the development of new drugs and treatment protocols, patient survival has not reached the desired level. In this study, we investiga
Externí odkaz:
https://doaj.org/article/af4cd353654e4b61a432b08a1a6b76f4
Autor:
Yuan Dong, Chengshi Quan
Publikováno v:
Cell Communication and Signaling, Vol 22, Iss 1, Pp 1-14 (2024)
Abstract Macroautophagy/autophagy is a lysosome-dependent catabolic process induced by various cellular stress conditions, maintaining the homeostasis of cells, tissues and organs. Autophagy is a series of membrane-related events involving multiple a
Externí odkaz:
https://doaj.org/article/a59e2690f73c4590b49e95aaa6bbceab
Autor:
Yizhi Zhang, Wan Li, Yihui Yang, Sen Zhang, Hong Yang, Yue Hao, Xu Fang, Guanhua Du, Jianyou Shi, Lianqiu Wu, Jinhua Wang
Publikováno v:
Cancer Cell International, Vol 24, Iss 1, Pp 1-18 (2024)
Abstract Background Glioblastoma (GBM) is the most common brain tumor with the worst prognosis. Temozolomide is the only first-line drug for GBM. Unfortunately, the resistance issue is a classic problem. Therefore, it is essential to develop new drug
Externí odkaz:
https://doaj.org/article/01fbfd9d0f554ad6bc9eb31003ab2d4a
Publikováno v:
Virulence, Vol 15, Iss 1 (2024)
ABSTRACTAutophagy is an intracellular degradation process that is important for the development and pathogenicity of phytopathogenic fungi and for the defence response of plants. However, the molecular mechanisms underlying autophagy in the pathogeni
Externí odkaz:
https://doaj.org/article/62391df107a8423b982f370f95aacfe8
Publikováno v:
Autophagy Reports, Vol 3, Iss 1 (2024)
ABSTRACTMacroautophagy (also known as autophagy) plays a pivotal role in maintaining cellular homeostasis. The terminal step of the multi-step autophagy degradation pathway involves fusion between the cargo-laden, double-membraned autophagosome and t
Externí odkaz:
https://doaj.org/article/bab6517028f847d4af9dab11262e1bd0
Akademický článek
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Autor:
Zhiqi Tian, Jiajie Diao
Publikováno v:
eLife, Vol 13 (2024)
A change in the electric charge of autophagosome membranes controls the recruitment of SNARE proteins to ensure that membrane fusion occurs at the right time during autophagy.
Externí odkaz:
https://doaj.org/article/64c1780c697c4960a8486f145e5fba4b
Autor:
Saori Shinoda, Yuji Sakai, Takahide Matsui, Masaaki Uematsu, Ikuko Koyama-Honda, Jun-ichi Sakamaki, Hayashi Yamamoto, Noboru Mizushima
Publikováno v:
eLife, Vol 12 (2024)
During macroautophagy, cytoplasmic constituents are engulfed by autophagosomes. Lysosomes fuse with closed autophagosomes but not with unclosed intermediate structures. This is achieved in part by the late recruitment of the autophagosomal SNARE synt
Externí odkaz:
https://doaj.org/article/ce4db38e03334ce29e4228c492ac1adb
Autor:
Xi Wang, Miaoyang Hu, Jingrong Chen, Xinyu Lou, Hongchao Zhang, Muhan Li, Jie Cheng, Tengfei Ma, Jianping Xiong, Rong Gao, Xufeng Chen, Jun Wang
Publikováno v:
Molecular Medicine, Vol 30, Iss 1, Pp 1-16 (2024)
Abstract Background Autophagic defects are involved in Methamphetamine (Meth)-induced neurotoxicity. Syntaxin 17 (Stx17), a member of the SNARE protein family, participating in several stages of autophagy, including autophagosome-late endosome/lysoso
Externí odkaz:
https://doaj.org/article/0ed9f8ce5a214742a41eb8f022b6a89c