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Causal effects of plasma metabolites on autoimmune hepatitis (AIH): a bidirectional two-sample mendelian randomization study

Autor: Zhen Zheng, Dahua Chen, Jiaming Lv, Juan Du, Kaitai Liu

Publikováno v: Scientific Reports, Vol 14, Iss 1, Pp 1-12 (2024)

Abstract Autoimmune hepatitis(AIH) is a chronic progressive inflammatory liver disease induced by loss of immune tolerance. The role of circulating metabolites in disease pathogenesis is unclear. This study aimed to investigate potential causal links

Externí odkaz: https://doaj.org/article/0ddbbf018a874988aa4eb4ebc1fd4216

Second- and third-line treatment agents in autoimmune hepatitis (AIH): Where do we stand?

Autor: Pinelopi Arvaniti, Ignasi Olivas, Sergio Rodriguez-Tajes, George N. Dalekos, Maria-Carlota Londoño

Publikováno v: Exploration of Digestive Diseases, Vol 3, Iss 2, Pp 92-106 (2024)

Autoimmune hepatitis (AIH) is a chronic liver disease of unknown aetiology that can lead to end stage liver disease if left without treatment. Corticosteroids with or without azathioprine (AZA) are considered the recommended standard first-line treat

Externí odkaz: https://doaj.org/article/f4e2757a52954dcdb40b0c6bfabe588e

Novel autoantibody targets identified in patients with autoimmune hepatitis (AIH) by PhIP-Seq reveals pathogenic insights.

Autor: Klepper A; Department of Medicine, University of California, San Francisco, USA.; UCSF Liver Center., Asaki J; Department of Biochemistry, University of California, San Francisco, USA.; Gladstone-UCSF Institute of Genomic Immunology, San Francisco, USA., Kung AF; Department of Biochemistry, University of California, San Francisco, USA., Vazquez SE; Department of Dermatology, Mass General Hospital, Boston, MA., Bodansky A; Department of Pediatrics, University of California, San Francisco, USA., Mitchell A; Chan Zuckerberg Biohub; San Francisco, CA, USA., Mann SA; Department of Biochemistry, University of California, San Francisco, USA.; Chan Zuckerberg Biohub; San Francisco, CA, USA., Zorn K; Department of Biochemistry, University of California, San Francisco, USA., Avila-Vargas I; Department of Medicine, University of California, San Francisco, USA., Kari S; Department of Medicine, University of California, San Francisco, USA., Tekeste M; Department of Medicine, University of California, San Francisco, USA., Castro J; Department of Medicine, University of California, San Francisco, USA., Lee B; Department of Medicine, University of California, San Francisco, USA., Duarte M; Department of Medicine, University of California, San Francisco, USA.; UCSF Liver Center., Khalili M; Department of Medicine, University of California, San Francisco, USA.; UCSF Liver Center., Yang M; Department of Medicine, University of California, San Francisco, USA., Wolters P; Department of Medicine, University of California, San Francisco, USA., Price J; Department of Medicine, University of California, San Francisco, USA.; UCSF Liver Center., Perito E; Department of Pediatrics, University of California, San Francisco, USA.; UCSF Liver Center., Feng S; Department of Surgery, University of California, San Francisco, USA.; UCSF Liver Center., Maher JJ; Department of Medicine, University of California, San Francisco, USA.; UCSF Liver Center., Lai JC; Department of Medicine, University of California, San Francisco, USA.; UCSF Liver Center., Weiler-Normann C; Department of Medicine, University Medical Center Hamburg-Eppendorf, Hamburg, Germany., Lohse AW; Department of Medicine, University Medical Center Hamburg-Eppendorf, Hamburg, Germany., DeRisi J; Department of Biochemistry, University of California, San Francisco, USA.; Chan Zuckerberg Biohub; San Francisco, CA, USA., Tana M; Department of Medicine, University of California, San Francisco, USA.; UCSF Liver Center.

Publikováno v: MedRxiv : the preprint server for health sciences [medRxiv] 2024 Oct 29. Date of Electronic Publication: 2024 Oct 29.

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