Cellular lethal damage of 64Cu incorporated in mammalian genome evaluated with Monte Carlo methods

Autor: Jhonatan Carrasco-Hernandez, José Ramos-Méndez, Elizabeth Padilla-Rodal, Miguel A. Avila-Rodriguez

Publikováno v: Frontiers in Medicine, Vol 10 (2023)

PurposeTargeted Radionuclide Therapy (TRT) with Auger Emitters (AE) is a technique that allows targeting specific sites on tumor cells using radionuclides. The toxicity of AE is critically dependent on its proximity to the DNA. The aim of this study

Externí odkaz: https://doaj.org/article/1e70d9bb68844643b34b7c333dcd2c4a

Synthesis and Biological Evaluation of 99mTc(I) Tricarbonyl Complexes Dual-Targeted at Tumoral Mitochondria

Autor: Diogo Figueiredo, Célia Fernandes, Francisco Silva, Elisa Palma, Paula Raposinho, Ana Belchior, Pedro Vaz, António Paulo

Publikováno v: Molecules, Vol 26, Iss 2, p 441 (2021)

For effective Auger therapy of cancer, the Auger-electron emitters must be delivered to the tumor cells in close proximity to a radiosensitive cellular target. Nuclear DNA is considered the most relevant target of Auger electrons to have augmented ra

Externí odkaz: https://doaj.org/article/f7bff5e5207f44f1b10a0680c2e9fbc6

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Cs-131 as an experimental tool for the investigation and quantification of the radiotoxicity of intracellular Auger decays in vitro

Autor: Mikael Jensen, Gregory Severin, Pil M. Fredericia, Ulli Köster, Torsten Groesser, Mattia Siragusa

Publikováno v: 'International Journal of Radiation Biology, pages: 1-14 (2020)
Fredericia, P M, Siragusa, M, Köster, U, Severin, G, Groesser, T & Jensen, M 2023, ' Cs-131 as an experimental tool for the investigation and quantification of the radiotoxicity of intracellular Auger decays in vitro ', International Journal of Radiation Biology, vol. 99, no. 1 . https://doi.org/10.1080/09553002.2020.1787541

Purpose: In this work, we set out to provide an experimental setup, using Cs-131, with associated dosimetry for studying relative biological effectiveness (RBE) of Auger emitters.Material and methods: Cs-131 decays by 100% electron capture producing

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5d233af0a270753768bdfb437dab2034
https://doi.org/10.1080/09553002.2020.1787541