Progressive Motor Neuron Pathology and the Role of Astrocytes in a Human Stem Cell Model of VCP-Related ALS

Autor: Claire E. Hall, Zhi Yao, Minee Choi, Giulia E. Tyzack, Andrea Serio, Raphaelle Luisier, Jasmine Harley, Elisavet Preza, Charlie Arber, Sarah J. Crisp, P. Marc D. Watson, Dimitri M. Kullmann, Andrey Y. Abramov, Selina Wray, Russell Burley, Samantha H.Y. Loh, L. Miguel Martins, Molly M. Stevens, Nicholas M. Luscombe, Christopher R. Sibley, Andras Lakatos, Jernej Ule, Sonia Gandhi, Rickie Patani

Publikováno v: Cell Reports, Vol 19, Iss 9, Pp 1739-1749 (2017)

Motor neurons (MNs) and astrocytes (ACs) are implicated in the pathogenesis of amyotrophic lateral sclerosis (ALS), but their interaction and the sequence of molecular events leading to MN death remain unresolved. Here, we optimized directed differen

Externí odkaz: https://doaj.org/article/550ea2af177d49298d42a25f23b48e54

Progressive Motor Neuron Pathology and the Role of Astrocytes in a Human Stem Cell Model of VCP-Related ALS

Autor: Hall, Claire E, Yao, Zhi, Choi, Minee, Tyzack, Giulia E, Serio, Andrea, Luisier, Raphaelle, Harley, Jasmine, Preza, Elisavet, Arber, Charlie, Crisp, Sarah J, Watson, P Marc D, Kullmann, Dimitri M, Abramov, Andrey Y, Wray, Selina, Burley, Russell, Loh, Samantha HY, Martins, L Miguel, Stevens, Molly M, Luscombe, Nicholas M, Sibley, Christopher R, Lakatos, Andras, Ule, Jernej, Gandhi, Sonia, Patani, Rickie

Publikováno v: Cell Reports
Cell Reports, Vol 19, Iss 9, Pp 1739-1749 (2017)
Hall, C E, Yao, Z, Choi, M, Tyzack, G E, Serio, A, Luisier, R, Harely, J, Preza, E, Arber, C, Crisp, S J, Watson, P M D, Kullmann, D, Abramov, A, Wray, S, Burley, R, Loh, S HY, Martins, M, Stevens, M, Luscombe, N M, Sibley, C R, Lakatos, A, Ule, J, Gandhi, S & Patani, R 2017, ' Progressive Motor Neuron Pathology and the Role of Astrocytes in a Human Stem Cell Model of VCP-Related ALS ', Cell Reports, vol. 19, no. 9, pp. 1739-1749 . https://doi.org/10.1016/j.celrep.2017.05.024
Hall, C E, Yao, Z, Choi, M, Tyzack, G E, Serio, A, Luisier, R, Harley, J, Preza, E, Arber, C, Crisp, S J, Watson, P M D, Kullmann, D M, Abramov, A Y, Wray, S, Burley, R, Loh, S H Y, Martins, L M, Stevens, M M, Luscombe, N M, Sibley, C R, Lakatos, A, Ule, J, Gandhi, S & Patani, R 2017, ' Progressive motor neuron pathology and the role of astrocytes in a Human Stem Cell Model of VCP-Related ALS ', Cell Reports, vol. 19, no. 9, pp. 1739-1749 . https://doi.org/10.1016/j.celrep.2017.05.024

Summary Motor neurons (MNs) and astrocytes (ACs) are implicated in the pathogenesis of amyotrophic lateral sclerosis (ALS), but their interaction and the sequence of molecular events leading to MN death remain unresolved. Here, we optimized directed

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fcbe1cdd5e6f1e217fd03e62d92dfeeb