Zobrazeno 1 - 10
of 2 814
pro vyhledávání: '"aso"'
Autor:
Priyanka Pant, Regalla Kumarswamy
Publikováno v:
RNA Biology, Vol 21, Iss 1, Pp 56-64 (2024)
Understanding RNA-protein interactions is crucial for deciphering the cellular functions and molecular mechanisms of regulatory RNAs. Consequently, there is a constant need to develop innovative and cost-effective methods to uncover such interactions
Externí odkaz:
https://doaj.org/article/a5f73a301e4748c8b2cdc72a61a9190b
Autor:
Ghaliah Obaid Alnefaie
Publikováno v:
Journal of Translational Medicine, Vol 22, Iss 1, Pp 1-16 (2024)
Abstract Lung Cancer (LC) is characterized by chemoresistance, which poses a significant clinical challenge and results in a poor prognosis for patients. Long non-coding RNAs (lncRNAs) have recently gained recognition as crucial mediators of chemores
Externí odkaz:
https://doaj.org/article/03abd398b8394d8392425858d96fa930
Publikováno v:
Acta Pharmaceutica Sinica B, Vol 14, Iss 9, Pp 3802-3817 (2024)
Small nucleic acid drugs, composed of nucleotides, represent a novel class of pharmaceuticals that differ significantly from conventional small molecule and antibody-based therapeutics. These agents function by selectively targeting specific genes or
Externí odkaz:
https://doaj.org/article/5915be80fbe64a2ebe7f9e79127c8733
Autor:
Yu Na Lim, In Soo Ryu, Yeon-Joo Jung, Gabriel Helmlinger, Insun Kim, Hye Won Park, Hansol Kang, Jina Lee, Hyo Jin Lee, Kang Seon Lee, Ha-Na Jang, Dae-In Ha, Junghyung Park, Jinyoung Won, Kyung Seob Lim, Chang-Yeop Jeon, Hyun-Jeong Cho, Hyun Su Min, Jin-Hyeob Ryu
Publikováno v:
Molecular Therapy: Nucleic Acids, Vol 35, Iss 4, Pp 102340- (2024)
l-Type amino acid transporter 1 (LAT1)-specific ligands and polyion complexes are used as brain-specific targets to deliver RNA-based drugs across the blood-brain barrier. We characterized an LAT1-targeting antisense oligonucleotide (ASO)-encapsulate
Externí odkaz:
https://doaj.org/article/75ccd5988ffe4c2d820c0368db49aea4
Autor:
Masahito Noguchi, Aya Miyauchi, Yoshiaki Masaki, Masashi Sakaki, Xiao-Feng Lei, Momoko Kobayashi-Tanabe, Akira Miyazaki, Takeshi Aoki, Hitoshi Yoshida, Kohji Seio, Joo-ri Kim-Kaneyama
Publikováno v:
JHEP Reports, Vol 6, Iss 11, Pp 101195- (2024)
Background & Aims: Chronic liver diseases, including metabolic dysfunction-associated steatohepatitis (MASH), pose a significant global health burden. Progressive liver fibrosis can lead to severe outcomes; however, there is a lack of effective thera
Externí odkaz:
https://doaj.org/article/1d0608e23cbc477c9c612c92c8d63df7
Autor:
Anastasiya Oshchepkova, Ivan Chernikov, Svetlana Miroshnichenko, Olga Patutina, Oleg Markov, Innokenty Savin, Yaroslav Staroseletz, Mariya Meschaninova, Pavel Puchkov, Sergey Zhukov, Maxim Kupryushkin, Mikhail Maslov, Aleksandra Sen’kova, Valentin Vlassov, Elena Chernolovskaya, Marina Zenkova
Publikováno v:
Frontiers in Bioengineering and Biotechnology, Vol 12 (2024)
IntroductionSmall membrane particles called extracellular vesicles (EVs) transport biologically active cargo between cells, providing intercellular communication. The clinical application of EVs is limited due to the lack of scalable and cost-effecti
Externí odkaz:
https://doaj.org/article/fbe4b738750047829b8eb0b14ff074ec
Publikováno v:
Conservation, Vol 4, Iss 2, Pp 201-215 (2024)
Protected areas (PAs) such as national parks face funding issues that undermine effective management. Therefore, many PAs are exploring new financial instruments, such as visitor donations, to supplement their conservation budgets. This paper investi
Externí odkaz:
https://doaj.org/article/fb6ec023491f4961854a2972031a8ee2
Autor:
Tatiana Akimova, Liqing Wang, Zhanna Bartosh, Lanette M. Christensen, Evgeniy Eruslanov, Sunil Singhal, Veenu Aishwarya, Wayne W. Hancock
Publikováno v:
Frontiers in Immunology, Vol 15 (2024)
Our goal is to improve the outcomes of cancer immunotherapy by targeting FOXP3+ T-regulatory (Treg) cells with a next generation of antisense oligonucleotides (ASO), termed FOXP3 AUMsilence ASO. We performed in vitro experiments with human healthy do
Externí odkaz:
https://doaj.org/article/a96f23f9055b414882bcdbc8711caf2b
Autor:
Xiaochang Zhang
Publikováno v:
Frontiers in Molecular Neuroscience, Vol 17 (2024)
Pediatric neurological disorders are frequently devastating and present unmet needs for effective medicine. The successful treatment of spinal muscular atrophy with splice-switching antisense oligonucleotides (SSO) indicates a feasible path to target
Externí odkaz:
https://doaj.org/article/cd25d3966b8f4bccb3957936e641c3e3
Autor:
John J. Rossi
Publikováno v:
Molecular Therapy: Nucleic Acids, Vol 35, Iss 2, Pp 102153- (2024)
Externí odkaz:
https://doaj.org/article/cb5d072960484faebbb63c6ae9f795fa