Zobrazeno 1 - 10
of 99
pro vyhledávání: '"arrigo de benedetti"'
Autor:
Damilola Olatunde, Arrigo De Benedetti
Publikováno v:
Cancers, Vol 16, Iss 16, p 2918 (2024)
Despite some advances in controlling the progression of prostate cancer (PCa) that is refractory to the use of ADT/ARSI, most patients eventually succumb to the disease, and there is a pressing need to understand the mechanisms that lead to the devel
Externí odkaz:
https://doaj.org/article/7e5e8ba8aa7e4ddba13539263e110aae
Autor:
Nadejda Korneeva, Md Imtiaz Khalil, Ishita Ghosh, Ruping Fan, Thomas Arnold, Arrigo De Benedetti
Publikováno v:
Virology Journal, Vol 20, Iss 1, Pp 1-20 (2023)
Abstract When viruses like SARS-CoV-2 infect cells, they reprogram the repertoire of cellular and viral transcripts that are being translated to optimize their strategy of replication, often targeting host translation initiation factors, particularly
Externí odkaz:
https://doaj.org/article/5ac50212fa3d4c03a9fa1341c0b6b481
Autor:
Terry C. Lairmore, Jehan Abdulsattar, Arrigo De Benedetti, Runhua Shi, Shile Huang, Md Imtiaz Khalil, Stephan N. Witt
Publikováno v:
BMC Research Notes, Vol 16, Iss 1, Pp 1-7 (2023)
Abstract Background MEN1, which codes for the protein menin, is a tumor suppressor in neuroendocrine tissue. In cholangiocarcinoma (CCA) cell lines the overexpression of menin decreased proliferation, angiogenesis, migration, and invasion in vitro an
Externí odkaz:
https://doaj.org/article/274d4b51de0545169d190e224abda9a9
Publikováno v:
Molecular Oncology, Vol 16, Iss 13, Pp 2537-2557 (2022)
Metastases account for the majority of prostate cancer (PCa) deaths, and targeting them is a major goal of systemic therapy. We identified a novel interaction between two kinases: tousled‐like kinase 1 (TLK1) and MAP kinase‐activated protein kina
Externí odkaz:
https://doaj.org/article/a97791e50edd49bebaf81ee84abc9659
Publikováno v:
Biomedicines, Vol 11, Iss 11, p 2987 (2023)
Cellular organisms possess intricate DNA damage repair and tolerance pathways to manage various DNA lesions arising from endogenous or exogenous sources. The dysregulation of these pathways is associated with cancer development and progression. Synth
Externí odkaz:
https://doaj.org/article/b0fe4599ff5f46a29fffb47220391ad0
Autor:
Ishita Ghosh, Arrigo De Benedetti
Publikováno v:
International Journal of Molecular Sciences, Vol 24, Iss 17, p 13369 (2023)
DNA damage repair lies at the core of all cells’ survival strategy, including the survival strategy of cancerous cells. Therefore, targeting such repair mechanisms forms the major goal of cancer therapeutics. The mechanism of DNA repair has been to
Externí odkaz:
https://doaj.org/article/f1c4b600055b4e65a2ae1b4678d03796
Autor:
Siddhant Bhoir, Arrigo De Benedetti
Publikováno v:
International Journal of Molecular Sciences, Vol 24, Iss 13, p 11100 (2023)
Androgen deprivation therapy (ADT) has been the mainstay of prostate cancer (PCa) treatment, with success in developing more effective inhibitors of androgen synthesis and antiandrogens in clinical practice. However, hormone deprivation and AR ablati
Externí odkaz:
https://doaj.org/article/781d31c0fe584ebc8f679ec15097630a
Publikováno v:
Pathophysiology, Vol 28, Iss 3, Pp 339-354 (2021)
Prostate cancer (PCa) progression is characterized by the emergence of resistance to androgen deprivation therapy (ADT). AKT/PKB has been directly implicated in PCa progression, often due to the loss of PTEN and activation of PI3K>PDK1>AKT signaling.
Externí odkaz:
https://doaj.org/article/ee2123cc34f24c6f90af44590e329179
Autor:
Ishita Ghosh, Md Imtiaz Khalil, Rusella Mirza, Judy King, Damilola Olatunde, Arrigo De Benedetti
Publikováno v:
Biomedicines, Vol 11, Iss 3, p 734 (2023)
The key to preventing mCRPC progression is understanding how androgen-dependent PCa cells progress to independence and modify their transcriptional repertoire accordingly. We recently identified a novel axis of the Hippo pathway characterized by the
Externí odkaz:
https://doaj.org/article/d88ffabf3eb74793a66821821328f642
Autor:
Md Imtiaz Khalil, Arrigo De Benedetti
Publikováno v:
Cancers, Vol 14, Iss 23, p 5728 (2022)
Background: Metastatic dissemination of prostate cancer (PCa) accounts for the majority of PCa-related deaths. However, the exact mechanism of PCa cell spread is still unknown. We uncovered a novel interaction between two unrelated promotility factor
Externí odkaz:
https://doaj.org/article/5fb76606240a4503b80fa5cd99d44a23