Zobrazeno 1 - 10
of 100
pro vyhledávání: '"arjan kortholt"'
Autor:
Lucia Iannotta, Rachel Fasiczka, Giulia Favetta, Yibo Zhao, Elena Giusto, Elena Dall’Ara, Jianning Wei, Franz Y. Ho, Claudia Ciriani, Susanna Cogo, Isabella Tessari, Ciro Iaccarino, Maxime Liberelle, Luigi Bubacco, Jean-Marc Taymans, Claudia Manzoni, Arjan Kortholt, Laura Civiero, Sabine Hilfiker, Michael L. Lu, Elisa Greggio
Publikováno v:
Cell Death and Disease, Vol 15, Iss 10, Pp 1-14 (2024)
Abstract P21 activated kinase 6 (PAK6) is a serine-threonine kinase with physiological expression enriched in the brain and overexpressed in a number of human tumors. While the role of PAK6 in cancer cells has been extensively investigated, the physi
Externí odkaz:
https://doaj.org/article/795a4c0f9a0e410b87c1129fe09b26ab
Autor:
Gargi Ahuja, Y. Laurisa Arenales Arauz, Marieke J. G. van Heuvelen, Arjan Kortholt, Tamás Oroszi, Eddy A. van der Zee
Publikováno v:
Frontiers in Neurology, Vol 15 (2024)
Whole-body vibration (WBV) therapy is a way of passive exercise in which subjects are exposed to mild and well-controlled mechanical vibrations through a vibrating platform. For a long time, studies have focused on the effects and applications of WBV
Externí odkaz:
https://doaj.org/article/26d7472d683646dd821acbc0a4883c0a
Autor:
Angélica María Sabogal-Guáqueta, Alejandro Marmolejo-Garza, Marina Trombetta-Lima, Asmaa Oun, Jasmijn Hunneman, Tingting Chen, Jari Koistinaho, Sarka Lehtonen, Arjan Kortholt, Justina C. Wolters, Barbara M. Bakker, Bart J. L. Eggen, Erik Boddeke, Amalia Dolga
Publikováno v:
Nature Communications, Vol 14, Iss 1, Pp 1-24 (2023)
Abstract Metabolic reprogramming is a hallmark of the immune cells in response to inflammatory stimuli. This metabolic process involves a switch from oxidative phosphorylation (OXPHOS) to glycolysis or alterations in other metabolic pathways. However
Externí odkaz:
https://doaj.org/article/84b22256347c40f5852d44e2ee2ceacc
Autor:
Lucia Iannotta, Marco Emanuele, Giulia Favetta, Giulia Tombesi, Laurine Vandewynckel, Antonio Jesús Lara Ordóñez, Jean-Michel Saliou, Matthieu Drouyer, William Sibran, Laura Civiero, R. Jeremy Nichols, Panagiotis S. Athanasopoulos, Arjan Kortholt, Marie-Christine Chartier-Harlin, Elisa Greggio, Jean-Marc Taymans
Publikováno v:
Frontiers in Molecular Neuroscience, Vol 16 (2023)
Mutations in leucine-rich repeat kinase 2 (LRRK2) are a common cause of inherited and sporadic Parkinson’s disease (PD) and previous work suggests that dephosphorylation of LRRK2 at a cluster of heterologous phosphosites is associated to disease. W
Externí odkaz:
https://doaj.org/article/5c7b59f9a8734bce82374910d2ad476b
Autor:
Angelica Sabogal, Alejandro Marmolejo, Marina Trombetta Lima, Asmaa Oun, Tingting Chen, Jari Koistinaho, Šarka Lehtonen, Arjan Kortholt, Barbara Bakker, Bart Eggen, Erik Boddeke, Amalia Dolga
Publikováno v:
IBRO Neuroscience Reports, Vol 15, Iss , Pp S254-S255 (2023)
Externí odkaz:
https://doaj.org/article/857f9ccf5da049a092ed81bdbafca19b
Autor:
Asmaa Oun, Ahmed Soliman, Marina Trombetta-Lima, Afroditi Tzepapadaki, Dikaia Tsagkari, Arjan Kortholt, Amalia M. Dolga
Publikováno v:
Neurobiology of Disease, Vol 175, Iss , Pp 105917- (2022)
Ferroptosis is an iron-dependent regulated cell death pathway characterized by excessive lipid peroxidation. It is implicated in many neurodegenerative diseases, including Parkinson's Disease (PD). Mutations and increased leucine-rich repeat kinase 2
Externí odkaz:
https://doaj.org/article/fe053db9011149baaa10a6feeb5c803b
Autor:
Xuehua Xu, Henderikus Pots, Bernd K. Gilsbach, Dustin Parsons, Douwe M. Veltman, Sharmila G. Ramachandra, Haoran Li, Arjan Kortholt, Tian Jin
Publikováno v:
Frontiers in Immunology, Vol 13 (2022)
Phagocytosis, macropinocytosis, and G protein coupled receptor-mediated chemotaxis are Ras-regulated and actin-driven processes. The common regulator for Ras activity in these three processes remains unknown. Here, we show that C2GAP2, a Ras GTPase a
Externí odkaz:
https://doaj.org/article/63ae01881cbf47c6a1fbbc45891e3fbe
Autor:
Asmaa Oun, Angelica Maria Sabogal-Guaqueta, Sekar Galuh, Anastasia Alexander, Arjan Kortholt, Amalia M. Dolga
Publikováno v:
Neurobiology of Disease, Vol 173, Iss , Pp 105837- (2022)
Parkinson's disease (PD) is the second most common neurodegenerative disease affecting elderly people. Pathogenic mutations in Leucine-Rich Repeat Kinase 2 (LRRK2) are the most common cause of autosomal dominant PD. LRRK2 activity is enhanced in both
Externí odkaz:
https://doaj.org/article/24ae28f7b4534a0d8f9e6a0afde74b0d
Publikováno v:
Frontiers in Neuroscience, Vol 16 (2022)
Externí odkaz:
https://doaj.org/article/caaf6fb89b3942219c4fd4647607c897
Autor:
Xiaojuan Zhang, Arjan Kortholt
Publikováno v:
Biomolecules, Vol 13, Iss 4, p 612 (2023)
Mutations in the multidomain protein Leucine-rich-repeat kinase 2 (LRRK2) have been identified as a genetic risk factor for both sporadic and familial Parkinson’s disease (PD). LRRK2 has two enzymatic domains: a RocCOR tandem with GTPase activity a
Externí odkaz:
https://doaj.org/article/40a5e3dbd9d749cf89be2a174e12e418