Zobrazeno 1 - 10
of 493
pro vyhledávání: '"arginase-i"'
Autor:
Ramesh Thylur Puttalingaiah, Matthew J. Dean, Liqin Zheng, Phaethon Philbrook, Dorota Wyczechowska, Timothy Kayes, Luis Del Valle, Denise Danos, Maria Dulfary Sanchez-Pino
Publikováno v:
Cells, Vol 13, Iss 20, p 1736 (2024)
Potassium ions (K+) are critical electrolytes that regulate multiple functions in immune cells. Recent studies have shown that the elevated concentration of extracellular potassium in the tumor interstitial fluid limits T cell effector function and s
Externí odkaz:
https://doaj.org/article/27b8b8922dc34a668a737aba8334e9c9
Autor:
Karrington A. McLeod, Madeleine Di Gregorio, Dylan Tinney, Justin Carmichael, David Zuanazzi, Walter L. Siqueira, Amin Rizkalla, Douglas W. Hamilton
Publikováno v:
Bioengineering, Vol 11, Iss 10, p 960 (2024)
Chronic wounds remain trapped in a pro-inflammatory state, with strategies targeted at inducing re-epithelialization and the proliferative phase of healing desirable. As a member of the lectin family, galectin-3 is implicated in the regulation of mac
Externí odkaz:
https://doaj.org/article/63c352f975d645a08abbae7592cc3c5f
Akademický článek
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Akademický článek
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Akademický článek
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Publikováno v:
Molecular Cancer, Vol 21, Iss 1, Pp 1-19 (2022)
Abstract The clinical responses observed following treatment with immune checkpoint inhibitors (ICIs) support immunotherapy as a potential anticancer treatment. However, a large proportion of patients cannot benefit from it due to resistance or relap
Externí odkaz:
https://doaj.org/article/d7af662eb0644094891aa0f0c567beeb
Autor:
Kelly L. Monaghan, Wen Zheng, Halima Akhter, Lei Wang, Amanda G. Ammer, Peng Li, Jian-Xin Lin, Gangqing Hu, Warren J. Leonard, Edwin C. K. Wan
Publikováno v:
Frontiers in Immunology, Vol 14 (2023)
In response to external stimuli during immune responses, monocytes can have multifaceted roles such as pathogen clearance and tissue repair. However, aberrant control of monocyte activation can result in chronic inflammation and subsequent tissue dam
Externí odkaz:
https://doaj.org/article/12045bbafd524595805dc67907514100
Autor:
Magdi E. A. Zaki, Sami A. Al-Hussain, Aamal A. Al-Mutairi, Abdul Samad, Arabinda Ghosh, Somdatta Chaudhari, Pravin N. Khatale, Prashant Ajmire, Rahul D. Jawarkar
Publikováno v:
Frontiers in Pharmacology, Vol 14 (2023)
Rudolf Virchow was the first person to point out the important link between immune function and cancer. He did this by noticing that leukocytes were often found in tumors. Overexpression of arginase 1 (ARG1) and inducible nitric oxide synthase (iNOS)
Externí odkaz:
https://doaj.org/article/0dbc6cc9656a43e2abb9d584f7e1244a
Autor:
Carolina Melero-Jerez, Margarita Suardíaz, Rafael Lebrón-Galán, Carmen Marín-Bañasco, Begoña Oliver-Martos, Isabel Machín-Díaz, Óscar Fernández, Fernando de Castro, Diego Clemente
Publikováno v:
Neurobiology of Disease, Vol 127, Iss , Pp 13-31 (2019)
Multiple sclerosis (MS) is an autoimmune demyelinating disease of the human central nervous system (CNS), mainly affecting young adults. Among the immunomodulatory disease modifying treatments approved up to date to treat MS, IFN-β remains to be one
Externí odkaz:
https://doaj.org/article/bdc793728b8c483382a1b841c1b6bc71
Autor:
V. I. Yakushev, M. V. Pokrovsky, E. A. Beskhmelnitsyna, O. V. Myasishcheva, A. S. Litvinova, I. I. Krivoshapova, S. A. Demchenko
Publikováno v:
Регуляторные исследования и экспертиза лекарственных средств, Vol 0, Iss 1, Pp 26-30 (2018)
RETRACTED ARTICLEThe article describes arginase’s role in pathogenesis of endothelial dysfunction and a number of cardio-vascular diseases. Arginase catalyzes the hydrolysis of L-arginine, the substrate for nitric oxide synthesis, to L-ornithine an
Externí odkaz:
https://doaj.org/article/5976fa1c432c4492a8224fc140a8f51b