Zobrazeno 1 - 10
of 471
pro vyhledávání: '"arginase 1"'
Autor:
Reena Sharma, John Bassett, Karolina M. Stepien, Andrew Oldham, Ana Jovanovic, Alison Woodall, Diane Green
Publikováno v:
JIMD Reports, Vol 65, Iss 6, Pp 382-391 (2024)
Abstract Background The clinical presentation of ARG1‐D is characterised by elevated arginine levels leading to neurological and mobility impairments. Information about long‐term outcomes in adults is lacking, which prompted us to undertake a ret
Externí odkaz:
https://doaj.org/article/1046e8b567b148329989c95b38ab4eb5
Autor:
Sara Olofsson, Sofia Löfvendahl, Julia Widén, Lena Jacobson, Peter Lindgren, Karolina M. Stepien, Jean‐Baptiste Arnoux, Maria Luz Couce Pico, Elisa Leão Teles, Mattias Rudebeck
Publikováno v:
JIMD Reports, Vol 65, Iss 6, Pp 450-460 (2024)
Abstract Arginase 1 deficiency (ARG1‐D) is an ultrarare, metabolic disease which may cause spastic paraplegia, cognitive deficiency, seizures, and ultimately severe disability. The aim of this study was to assess disease burden in ARG1‐D by perfo
Externí odkaz:
https://doaj.org/article/75e89c23a1d74a5e915f5192fa93b4ec
Autor:
Ammar A. Abdelrahman, Porsche V. Sandow, Jing Wang, Zhimin Xu, Modesto Rojas, John S. Bomalaski, Tahira Lemtalsi, Ruth B. Caldwell, Robert W. Caldwell
Publikováno v:
Molecular Metabolism, Vol 89, Iss , Pp 102020- (2024)
Objective: Chronic inflammation and oxidative stress mediate the pathological progression of diabetic complications, like diabetic retinopathy (DR), peripheral neuropathy (DPN) and impaired wound healing. Studies have shown that treatment with a stab
Externí odkaz:
https://doaj.org/article/c237de2e14d94104aab7e234e7dfe042
Publikováno v:
Journal of Neuroinflammation, Vol 21, Iss 1, Pp 1-25 (2024)
Abstract Background Since the 1990s, evidence has accumulated that macrophages promote peripheral nerve regeneration and are required for enhancing regeneration in the conditioning lesion (CL) response. After a sciatic nerve injury, macrophages accum
Externí odkaz:
https://doaj.org/article/0091155cbdae4545a8bcb622782029dd
Autor:
Mahlatse C.M. Kgokolo, Nonkululeko Z. Malinga, Helen C. Steel, Pieter W.A. Meyer, Teresa Smit, Ronald Anderson, Bernardo L. Rapoport
Publikováno v:
Translational Oncology, Vol 42, Iss , Pp 101867- (2024)
The current study compared the levels and possible associations between systemic soluble immune checkpoints (sICPs, n = 17) and a group of humoral modulators of immune suppressor cells (n = 7) in a cohort of patients with basal cell carcinoma (BCC, n
Externí odkaz:
https://doaj.org/article/c0ab158b62254a1ea1136ad9355f146d
Publikováno v:
Zhongguo linchuang yanjiu, Vol 36, Iss 12, Pp 1836-1841 (2023)
Objective To investigate the effect of moist exposed burn therapy (MEBT) /moist exposed burn ointment (MEBO) on the expression of inducible nitric oxide synthase (iNOS) and arginase 1 (Arg1) in diabetic wounds. Methods Forty-eight male Wistar rats we
Externí odkaz:
https://doaj.org/article/0c4a2b02823543279e0e34e4e04188cb
Autor:
Ansooya A. Bokil, Mathieu Le Boulvais Børkja, Camilla Wolowczyk, Apsana Lamsal, Wenche S. Prestvik, Unni Nonstad, Kristine Pettersen, Sonja B. Andersen, Anna M. Bofin, Geir Bjørkøy, Sjoerd Hak, Miriam S. Giambelluca
Publikováno v:
Cancer Cell International, Vol 23, Iss 1, Pp 1-18 (2023)
Abstract Background Myeloid cells play an essential role in cancer metastasis. The phenotypic diversity of these cells during cancer development has attracted great interest; however, their functional heterogeneity and plasticity have limited their r
Externí odkaz:
https://doaj.org/article/2b168043f5c548d19af126098f6ac5e5
Publikováno v:
Medičnì Perspektivi, Vol 28, Iss 3, Pp 55-61 (2023)
The paper was aimed at determination of the quantitative activity of iNOS and Arg1, as well as M1 and M2 phenotype macrophages in women with endometrioid disease to establish their role in the pathogenesis of endometriosis. A prospective study was
Externí odkaz:
https://doaj.org/article/d42c260971554972883eb17afe7c9057
Autor:
Rossana Sanchez Russo, Serena Gasperini, Gillian Bubb, Linda Neuman, Leslie S. Sloan, George A. Diaz, Gregory M. Enns
Publikováno v:
EClinicalMedicine, Vol 68, Iss , Pp 102405- (2024)
Summary: Background: Arginase 1 Deficiency (ARG1-D) is a rare debilitating, progressive, inherited, metabolic disease characterized by marked increases in plasma arginine (pArg) and its metabolites, with increased morbidity, substantial reductions in
Externí odkaz:
https://doaj.org/article/adc9776bffef450085166ec27d071c74
Publikováno v:
Медицинская иммунология, Vol 25, Iss 3, Pp 507-512 (2023)
During pregnancy, the maternal immune system must maintain tolerance to paternal antigens, at the same time being able to eliminate pathogens, which is achieved by the weakening of adoptive immunity and the activation of innate immunity, in particula
Externí odkaz:
https://doaj.org/article/21322154f31e45a1babc88ac29a38a02