Targeting Pro-Oxidant Iron with Exogenously Administered Apotransferrin Provides Benefits Associated with Changes in Crucial Cellular Iron Gate Protein TfR in a Model of Intracerebral Hemorrhagic Stroke in Mice

Autor: Alexia García-Serran, Jesús Ordoño, Núria DeGregorio-Rocasolano, Marc Melià-Sorolla, Karla Odendaal, Octavi Martí-Sistac, Teresa Gasull

Publikováno v: Antioxidants, Vol 12, Iss 11, p 1945 (2023)

We have previously demonstrated that the post-stroke administration of iron-free transferrin (apotransferrin, ATf) is beneficial in different models of ischemic stroke (IS) through the inhibition of the neuronal uptake of pro-oxidant iron. In the pre

Externí odkaz: https://doaj.org/article/cc9117fbdea742908262e43c0ddfd323

Iron-loaded transferrin (Tf) is detrimental whereas iron-free Tf confers protection against brain ischemia by modifying blood Tf saturation and subsequent neuronal damage

Autor: Nuria DeGregorio-Rocasolano, Octavi Martí-Sistac, Jovita Ponce, María Castelló-Ruiz, Mònica Millán, Verónica Guirao, Isaac García-Yébenes, Juan B. Salom, Pedro Ramos-Cabrer, Enrique Alborch, Ignacio Lizasoain, José Castillo, Antoni Dávalos, Teresa Gasull

Publikováno v: Redox Biology, Vol 15, Iss C, Pp 143-158 (2018)

Despite transferrin being the main circulating carrier of iron in body fluids, and iron overload conditions being known to worsen stroke outcome through reactive oxygen species (ROS)-induced damage, the contribution of blood transferrin saturation (T

Externí odkaz: https://doaj.org/article/facd8b78a4874d8e865b236e82696fcb

Vesicular transport of Fe and interaction with other metal ions in polarized Caco2 Cell monolayers

Autor: MARIA C LINDER, MIZUE MORIYA, ANNE WHON, AZEB KASSA, CYNTHIA GILLEY

Publikováno v: Biological Research, Vol 39, Iss 1, Pp 143-156 (2006)

Two aspects of the mechanisms by which iron is absorbed by the intestine were studied in the Caco2 cell model, using 59Fe(II)-ascorbate. Data showing the importance of vesicular processes and cycling of apotransferrin (apoTf) to uptake and overall tr

Externí odkaz: https://doaj.org/article/76683bcb0a3e4d63a37fb07d2b0f6681

Study of Nonenzymatic Glycation of Transferrin and its Effect on Iron –Binding Antioxidant Capacity

Autor: Mohammad Taghi Goodarzi, Mojtaba Rashidi, Mohsen Rezaei

Publikováno v: Iranian Journal of Basic Medical Sciences, Vol 13, Iss 47 (2010)

Objective(s)Nonenzymatic glycosylation (glycation) occurs in many macromolecules in aging and diabetes due to exposure of biomolecules to high level of glucose. Glycation can changes function, activities and structure of many biomolecules. Considerin

Externí odkaz: https://doaj.org/article/8309856b2a6544a68eb7ec6318d085d1

Iron-loaded transferrin (Tf) is detrimental whereas iron-free Tf confers protection against brain ischemia by modifying blood Tf saturation and subsequent neuronal damage

Autor: Juan B. Salom, Enrique Alborch, Teresa Gasull, Isaac García-Yébenes, Pedro Ramos-Cabrer, Ignacio Lizasoain, María Castelló-Ruiz, Jovita Ponce, Verónica Guirao, Mónica Millán, José Castillo, Antoni Dávalos, Octavi Martí-Sistac, Nuria DeGregorio-Rocasolano

Publikováno v: Dipòsit Digital de Documents de la UAB
Universitat Autònoma de Barcelona
Redox Biology
r-IGTP. Repositorio Institucional de Producción Científica del Instituto de Investigación Germans Trias i Pujol
instname
Redox Biology, Vol 15, Iss C, Pp 143-158 (2018)
r-IIS La Fe. Repositorio Institucional de Producción Científica del Instituto de Investigación Sanitaria La Fe
Minerva. Repositorio Institucional de la Universidad de Santiago de Compostela

Despite transferrin being the main circulating carrier of iron in body fluids, and iron overload conditions being known to worsen stroke outcome through reactive oxygen species (ROS)-induced damage, the contribution of blood transferrin saturation (T

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::810b789a7d186b24d714a1ffbfc93687
https://ddd.uab.cat/record/190741