Zobrazeno 1 - 10
of 1 580
pro vyhledávání: '"apoptosis induction"'
Autor:
Thi-Huong Nguyen, Huey-Jiun Ko, Po-Yu Tsai, Tai-Shan Cheng, Thu-Ha Tran, Ly Hien Doan, Michael Hsiao, Peter Mu-Hsin Chang, Hsiao-Sheng Liu, Yi-Ren Hong, Chi-Ying F. Huang
Publikováno v:
Frontiers in Pharmacology, Vol 15 (2024)
Colorectal cancer (CRC) is one of the primary contributors to cancer-related fatalities, with up to 80% of advanced CRC cases exhibiting mutations in the p53 gene. Unfortunately, the development of new compounds targeting mutant p53 is quite limited.
Externí odkaz:
https://doaj.org/article/175e1107fd754719a53e6fa4e741b36b
Autor:
Shailee V. Tiwari, Dattatraya N. Pansare, Deepak K. Lokwani, Shashikant V. Bhandari, Vijay V. Kanode, Omkar V. Tandale, Akshay R. Kadam
Publikováno v:
Results in Chemistry, Vol 11, Iss , Pp 101760- (2024)
For the treatment of NSCLC one of the promising strategies is targeted inhibition of EGFR and its mutants. In this research work, we tend to epitomize design, synthesis, in-vitro anticancer evaluation of novel indole-thiazole derivatives as novel rev
Externí odkaz:
https://doaj.org/article/39474eb0cf224a37bc25e6fe10c53228
Autor:
Marwa E. Abdelaziz, Mostafa M. M. El-Miligy, Salwa M. Fahmy, Marwa M. Abu-Serie, Aly A. Hazzaa, Mona A. Mahran
Publikováno v:
Journal of Enzyme Inhibition and Medicinal Chemistry, Vol 39, Iss 1 (2024)
AbstractNew aromatic O-alkyl pyridine derivatives were designed and synthesised as Proviral Integration Moloney (PIM)-1 kinase inhibitors. 4c and 4f showed potent in vitro anticancer activity against NFS-60, HepG-2, PC-3, and Caco-2 cell lines and lo
Externí odkaz:
https://doaj.org/article/e162c88d829d4fc1b977203714ab0d09
Autor:
Chien-Shan Cheng, Yuan Wu, Jia-Bin Jin, Jia-Yue Xu, Pei-Wen Yang, Wen-Hua Zhu, Lan Zheng, Jing-Xian Chen
Publikováno v:
Frontiers in Pharmacology, Vol 15 (2024)
Background:Cynanchum paniculatum (Bunge) Kitag. ex H.Hara, a member of the Asclepiadaceae family, has a rich history as a traditional Chinese medicinal plant used to treat digestive disorders. However, its potential anti-cancer effects in pancreatic
Externí odkaz:
https://doaj.org/article/a829d888e58f4851b27a7b7000c511c7
Publikováno v:
Frontiers in Pharmacology, Vol 15 (2024)
Breast cancer (BC) continues to be a major health challenge globally, ranking as the fifth leading cause of cancer mortality among women, despite advancements in cancer detection and treatment. In this study, we identified four novel compounds from m
Externí odkaz:
https://doaj.org/article/9b4f0765832044aea21d4e9fa4e466db
Publikováno v:
Journal of Tropical Life Science, Vol 13, Iss 3, Pp 589-598 (2023)
Indonesians have a rich tradition of incorporating black rice into their diet as a functional food due to its high antioxidant content. This research investigates the effects of the ethanolic extract of "Sembada Hitam" black rice bran on T47D breast
Externí odkaz:
https://doaj.org/article/cdd737dfba814ffb9d15d1d0996d00c3
Autor:
Juan Carlos García-Acosta, Alejando Israel Castillo-Montoya, Gareth Omar Rostro-Alonso, Edgar Yebrán Villegas-Vázquez, Laura Itzel Quintas-Granados, Luis Sánchez-Sánchez, Hugo López-Muñóz, Lizbeth Cariño-Calvo, Israel López-Reyes, Lilia Patricia Bustamante-Montes, Gerardo Leyva-Gómez, Hernán Cortés, Nadia Judith Jacobo-Herrera, Rosario García-Aguilar, Octavio Daniel Reyes-Hernández, Gabriela Figueroa-González
Publikováno v:
Molecules, Vol 29, Iss 18, p 4476 (2024)
Lithium, a natural element, has been employed as a mental stabilizer in psychiatric treatments; however, some reports indicate it has an anticancer effect, prompting the consideration of repurposing lithium for cancer treatment. The potential antican
Externí odkaz:
https://doaj.org/article/873c372376e942b49ad5d9e5c522c0df
Autor:
Cécile Letulle, François-Xavier Toublet, Aline Pinon, Soufyane Hba, Aurélie Laurent, Vincent Sol, Catherine Fagnère, Benjamin Rioux, Florent Allais, Sophie Michallet, Laurence Lafanechère, Youness Limami, Mounia Oudghiri, Mohamed Othman, Adam Daïch, Bertrand Liagre, Ata Martin Lawson, Christelle Pouget
Publikováno v:
Pharmaceuticals, Vol 17, Iss 9, p 1207 (2024)
In the context of designing innovative anticancer agents, the synthesis of a series of chalcones bearing a 3,4,5-trimethoxylated A ring and a variety of B rings, including phenols and original heterocycles such as chromones, was conducted. For this e
Externí odkaz:
https://doaj.org/article/bcc1be4f4ae54c15861b7cb9f5906914
Autor:
Hesham Haffez, Nosaiba A. Elsayed, Marwa F. Ahmed, Samar S. Fatahala, Eman F. Khaleel, Rehab Mustafa Badi, Eslam B. Elkaeed, Mahmoud A. El Hassab, Sherif F. Hammad, Wagdy M. Eldehna, Nicolas Masurier, Radwan El-Haggar
Publikováno v:
Journal of Enzyme Inhibition and Medicinal Chemistry, Vol 38, Iss 1 (2023)
Significant advancements have been made in the domain of targeted anticancer therapy for the management of malignancies in recent times. VEGFR-2 is characterised by its pivotal involvement in angiogenesis and subsequent mechanisms that promote tumour
Externí odkaz:
https://doaj.org/article/8fcc8ea833f943b4862f2890cfe139e0
Autor:
Mostafa M. M. El-Miligy, Marwa E. Abdelaziz, Salwa M. Fahmy, Tamer M. Ibrahim, Marwa M. Abu-Serie, Mona A. Mahran, Aly A. Hazzaa
Publikováno v:
Journal of Enzyme Inhibition and Medicinal Chemistry, Vol 38, Iss 1 (2023)
New quinoline-pyridine hybrids were designed and synthesised as PIM-1/2 kinase inhibitors. Compounds 5b, 5c, 6e, 13a, 13c, and 14a showed in-vitro low cytotoxicity against normal human lung fibroblast Wi-38 cell line and potent in-vitro anticancer ac
Externí odkaz:
https://doaj.org/article/9e34b94d9a5b4637adf59e548997a9d7