Zobrazeno 1 - 10
of 831
pro vyhledávání: '"antonio federico"'
Autor:
Jack Morikka, Antonio Federico, Lena Möbus, Simo Inkala, Alisa Pavel, Saara Sani, Maaret Vaani, Sanna Peltola, Angela Serra, Dario Greco
Publikováno v:
Computational and Structural Biotechnology Journal, Vol 25, Iss , Pp 194-204 (2024)
Immune signalling is a crucial component in the progression of fibrosis. However, approaches for the safety assessment of potentially profibrotic substances, that provide information on mechanistic immune responses, are underdeveloped. This study aim
Externí odkaz:
https://doaj.org/article/1ca6b54036f0412798f7216390d10183
Autor:
Giorgia Migliaccio, Jack Morikka, Giusy del Giudice, Maaret Vaani, Lena Möbus, Angela Serra, Antonio Federico, Dario Greco
Publikováno v:
Computational and Structural Biotechnology Journal, Vol 25, Iss , Pp 143-152 (2024)
Macrophage plasticity allows the adoption of distinct functional states in response to environmental cues. While unique transcriptomic profiles define these states, focusing solely on transcription neglects potential long-term effects. The investigat
Externí odkaz:
https://doaj.org/article/6bce4f91d2d447fda049f858a40f4f0c
Autor:
Mari Palviainen, Johanna Puutio, Rikke Halse Østergaard, Johannes A. Eble, Katariina Maaninka, Umar Butt, Joseph Ndika, Otto K. Kari, Masood Kamali‐Moghaddam, Kasper Kjaer‐Sorensen, Claus Oxvig, Ana M. Aransay, Juan M. Falcon‐Perez, Antonio Federico, Dario Greco, Saara Laitinen, Yuya Hayashi, Pia R.‐M. Siljander
Publikováno v:
Journal of Extracellular Vesicles, Vol 13, Iss 10, Pp n/a-n/a (2024)
Abstract Renowned for their role in haemostasis and thrombosis, platelets are also increasingly recognized for their contribution in innate immunity, immunothrombosis and inflammatory diseases. Platelets express a wide range of receptors, which allow
Externí odkaz:
https://doaj.org/article/d1bacf0104064fd49990f7e4e0293c8c
Autor:
Giusy del Giudice, Angela Serra, Alisa Pavel, Marcella Torres Maia, Laura Aliisa Saarimäki, Michele Fratello, Antonio Federico, Harri Alenius, Bengt Fadeel, Dario Greco
Publikováno v:
Advanced Science, Vol 11, Iss 32, Pp n/a-n/a (2024)
Abstract Hazard assessment is the first step in evaluating the potential adverse effects of chemicals. Traditionally, toxicological assessment has focused on the exposure, overlooking the impact of the exposed system on the observed toxicity. However
Externí odkaz:
https://doaj.org/article/3113aa82df4d44aaa47e36e21619b12f
Publikováno v:
Advanced Science, Vol 11, Iss 30, Pp n/a-n/a (2024)
Abstract The categorization of human diseases is mainly based on the affected organ system and phenotypic characteristics. This is limiting the view to the pathological manifestations, while it neglects mechanistic relationships that are crucial to d
Externí odkaz:
https://doaj.org/article/bb369be3e7084753a198b6d53ec88340
Autor:
Antonio Federico, Lena Möbus, Zeyad Al-Abdulraheem, Alisa Pavel, Vittorio Fortino, Giusy del Giudice, Harri Alenius, Nanna Fyhrquist, Dario Greco
Publikováno v:
Journal of Translational Medicine, Vol 22, Iss 1, Pp 1-13 (2024)
Abstract Background Atopic dermatitis (AD) is a prevalent chronic inflammatory skin disease whose pathophysiology involves the interplay between genetic and environmental factors, ultimately leading to dysfunction of the epidermis. While several trea
Externí odkaz:
https://doaj.org/article/8b2ab85eecfc497e92b3317b3f61f1f0
Autor:
Stephen Morris, Julie Vallortigara, Julie Greenfield, Barry Hunt, Deborah Hoffman, Carola Reinhard, Holm Graessner, Antonio Federico, Vinciane Quoidbach, Paola Giunti
Publikováno v:
Orphanet Journal of Rare Diseases, Vol 18, Iss 1, Pp 1-8 (2023)
Abstract Background Little is known about the costs of treating ataxia and whether treatment at a specialist ataxia centre affects the cost of care. The aim of this study was to investigate whether patients who attended specialist ataxia centres in t
Externí odkaz:
https://doaj.org/article/73a4cd848505400d97c064c0db95d331
Autor:
Julie Vallortigara, Julie Greenfield, Barry Hunt, Deborah Hoffman, Carola Reinhard, Holm Graessner, Antonio Federico, Vinciane Quoidbach, Steve Morris, Paola Giunti
Publikováno v:
Orphanet Journal of Rare Diseases, Vol 18, Iss 1, Pp 1-10 (2023)
Abstract Background Progressive ataxias are rare and complex neurological disorders that represent a challenge for the clinicians to diagnose and manage them. This study explored the patient pathways of individuals attending specialist ataxia centres
Externí odkaz:
https://doaj.org/article/e065d538ca3d4f04a022a5f8a436d69d
Autor:
Antonio Federico, Alisa Pavel, Lena Möbus, David McKean, Giusy del Giudice, Vittorio Fortino, Hanna Niehues, Joe Rastrick, Kilian Eyerich, Stefanie Eyerich, Ellen van den Bogaard, Catherine Smith, Stephan Weidinger, Emanuele de Rinaldis, Dario Greco
Publikováno v:
Human Genomics, Vol 16, Iss 1, Pp 1-16 (2022)
Abstract In recent years, a growing interest in the characterization of the molecular basis of psoriasis has been observed. However, despite the availability of a large amount of molecular data, many pathogenic mechanisms of psoriasis are still poorl
Externí odkaz:
https://doaj.org/article/8473f595cc8244e4b27dafb8dc20816a
Autor:
Katariina Maaninka, Maarit Neuvonen, Erja Kerkelä, Kati Hyvärinen, Mari Palviainen, Masood Kamali-Moghaddam, Antonio Federico, Dario Greco, Saara Laitinen, Katariina Öörni, Pia RM Siljander
Publikováno v:
European Journal of Cell Biology, Vol 102, Iss 2, Pp 151311- (2023)
Platelet extracellular vesicles (PEVs) generated upon platelet activation may play a role in inflammatory pathologies such as atherosclerosis. Oxidized low-density lipoprotein (oxLDL), a well-known contributor to atherogenesis, activates platelets an
Externí odkaz:
https://doaj.org/article/53441755532f4df7902743fa696d36a4