Isolation and functional analysis of phage‐displayed antibody fragments targeting the staphylococcal superantigen‐like proteins

Autor: Ida Alanko, Rebecca Sandberg, Eeva‐Christine Brockmann, Carla J. C. deHaas, Jos A. G. vanStrijp, Urpo Lamminmäki, Outi M. H. Salo‐Ahen

Publikováno v: MicrobiologyOpen, Vol 12, Iss 4, Pp n/a-n/a (2023)

Abstract Staphylococcus aureus produces numerous virulence factors that manipulate the immune system, helping the bacteria avoid phagocytosis. In this study, we are investigating three immune evasion molecules called the staphylococcal superantigen�

Externí odkaz: https://doaj.org/article/6fdee959588f4c3087aa0871c5a809ad

Identification of FDA-approved antivirulence drugs targeting the Pseudomonas aeruginosa quorum sensing effector protein PqsE

Autor: Valerio Baldelli, Francesca D’Angelo, Viola Pavoncello, Ersilia Vita Fiscarelli, Paolo Visca, Giordano Rampioni, Livia Leoni

Publikováno v: Virulence, Vol 11, Iss 1, Pp 652-668 (2020)

The ability of the bacterial pathogen Pseudomonas aeruginosa to cause both chronic and acute infections mainly relies on its capacity to finely modulate the expression of virulence factors through a complex network of regulatory circuits, including t

Externí odkaz: https://doaj.org/article/7e2d2cbeaef94dbdacc17226a46ffa91

Activity of a Synthetic Peptide Targeting MgtC on Pseudomonas aeruginosa Intramacrophage Survival and Biofilm Formation

Autor: Malika Moussouni, Pauline Nogaret, Preeti Garai, Bérengère Ize, Eric Vivès, Anne-Béatrice Blanc-Potard

Publikováno v: Frontiers in Cellular and Infection Microbiology, Vol 9 (2019)

Antivirulence strategies aim to target pathogenicity factors while bypassing the pressure on the bacterium to develop resistance. The MgtC membrane protein has been proposed as an attractive target that is involved in the ability of several major bac

Externí odkaz: https://doaj.org/article/f99e4b40ba914d5d8b54bc388b6cdc95

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Therapeutic Strategies To Counteract Antibiotic Resistance in MRSA Biofilm‐Associated Infections

Autor: Stella Cascioferro, Elisa Giovannetti, Patrizia Diana, Barbara Parrino, Girolamo Cirrincione, Daniela Carbone, Camilla Pecoraro

Publikováno v: Cascioferro, S, Carbone, D, Parrino, B, Pecoraro, C, Giovannetti, E, Cirrincione, G & Diana, P 2021, ' Therapeutic Strategies To Counteract Antibiotic Resistance in MRSA Biofilm-Associated Infections ', ChemMedChem, vol. 16, no. 1, pp. 65-80 . https://doi.org/10.1002/cmdc.202000677

Methicillin-resistant Staphylococcus aureus (MRSA) has emerged as one of the leading causes of persistent human infections. This pathogen is widespread and is able to colonize asymptomatically about a third of the population, causing moderate to seve

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e17ea7ddaf54209eba1812cdaa800957
https://doi.org/10.1002/cmdc.202000677