Zobrazeno 1 - 10
of 2 785
pro vyhledávání: '"antitumor efficacy"'
Autor:
O. I. Kit, I. P. Kodonidi, E. M. Frantsiyants, I. V. Kaplieva, A. A. Glushko, L. K. Trepitaki, E. I. Surikova, V. A. Bandovkina, Yu. A. Pogorelova, I. V. Neskubina, O. V. Bykadorova, E. V. Serdyukova
Publikováno v:
Issledovaniâ i Praktika v Medicine, Vol 11, Iss 3, Pp 54-64 (2024)
Purpose of the study. Preclinical study in experiment of antitumor efficacy of a new substance synthesized on the basis of pyrimidin-4-one derivative.Materials and methods. The sodium salt of 4-{2-[2-[2-(4-hydroxy-3-methoxyphenyl)-vinyl]-6-ethyl-4-ox
Externí odkaz:
https://doaj.org/article/4b51c4950fcd4ca4825e526a17a86a60
Publikováno v:
International Journal of Nanomedicine, Vol Volume 19, Pp 7871-7893 (2024)
Yu Been Shin,1,* Ju-Yeon Choi,2,* Moon Sup Yoon,1 Myeong Kyun Yoo,1 Dae Hwan Shin,1,3,* Jeong-Won Lee4,5,* 1College of Pharmacy, Chungbuk National University, Cheongju, 28160, Republic of Korea; 2Research Institute for Future Medicine
Externí odkaz:
https://doaj.org/article/69cf1cac311c4b34843b8cf31cd1a1e5
Publikováno v:
International Journal of Hyperthermia, Vol 41, Iss 1 (2024)
Background Cryoablation (Cryo) is a minimally invasive treatment for tumors. Cryo can activate the body’s immune response, although it is typically weak. The immune response induced by Cryo in hepatocellular carcinoma (HCC) is poorly understood. PD
Externí odkaz:
https://doaj.org/article/1602c249cccb436eab57988e3fb6db96
Publikováno v:
International Journal of Nanomedicine, Vol Volume 19, Pp 4679-4699 (2024)
Xi Wang,1 Xinxin Liu,1 Yaoyao Guo,1,2 Tingting Gong,1 Wenmin Lu,1,3 Meihua Han,1 Yifei Guo,1 Xiangtao Wang1 1Institute of Medicinal Plant Development, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, People’s Republic
Externí odkaz:
https://doaj.org/article/ad8f7d0700d644eb8475659a75f21f6b
Autor:
Jung Suk Kim, Seunghyun Cheon, Mi Ran Woo, Sanghyun Woo, Jee-Eun Chung, Yu Seok Youn, Kyung Taek Oh, Soo-Jeong Lim, Sae Kwang Ku, Bao Loc Nguyen, Jong Oh Kim, Sung Giu Jin, Han-Gon Choi
Publikováno v:
Asian Journal of Pharmaceutical Sciences, Vol 19, Iss 5, Pp 100953- (2024)
While spray-drying has been widely utilized to improve the bioavailability of poorly water-soluble drugs, the outcomes often exhibit suboptimal particle size distribution and large particle sizes, limiting their effectiveness. In this study, we intro
Externí odkaz:
https://doaj.org/article/844b702e265c4c8c97a71e59fa692049
Autor:
Naoya Nishioka, Hayato Kawachi, Tadaaki Yamada, Motohiro Tamiya, Yoshiki Negi, Yasuhiro Goto, Akira Nakao, Shinsuke Shiotsu, Keiko Tanimura, Takayuki Takeda, Asuka Okada, Taishi Harada, Koji Date, Yusuke Chihara, Isao Hasegawa, Nobuyo Tamiya, Taiki Masui, Natsuki Sai, Masaki Ishida, Yuki Katayama, Kenji Morimoto, Masahiro Iwasaku, Shinsaku Tokuda, Takashi Kijima, Koichi Takayama
Publikováno v:
Frontiers in Immunology, Vol 15 (2024)
IntroductionSeveral studies explored the association between thyroid transcription factor-1 (TTF-1) and the therapeutic efficacy of immunotherapy. However, the effect of TTF-1 on the therapeutic efficacy of programmed death-1 (PD-1) inhibitor/chemoim
Externí odkaz:
https://doaj.org/article/b283d63fa0724718827e2777a8b09bb4
Publikováno v:
MedComm, Vol 5, Iss 5, Pp n/a-n/a (2024)
Abstract Single‐domain antibody–drug conjugates (sdADCs) have been proven to have deeper solid tumor penetration and intratumor accumulation capabilities due to their smaller size compared with traditional IgG format ADCs. However, one of the key
Externí odkaz:
https://doaj.org/article/a82ab916581c41bf94b1b718a6ead906
Autor:
Peng-Fei Zhang, Dan Xie
Publikováno v:
Frontiers in Immunology, Vol 15 (2024)
Chimeric antigen receptor (CAR) -T cell therapy has achieved tremendous efficacy in the treatment of hematologic malignancies and represents a promising treatment regimen for cancer. Despite the striking response in patients with hematologic malignan
Externí odkaz:
https://doaj.org/article/166fe549a02f4be6ba170a700c279ebc
Publikováno v:
Cancer Nanotechnology, Vol 14, Iss 1, Pp 1-21 (2023)
Abstract Purpose Owing to the complexity of cancer, a synergistic combination of chemotherapy and gene therapy can be a promising therapeutic strategy. This study aimed to use stem cell membrane (SCM)-camouflaged polydopamine nanoparticles for simult
Externí odkaz:
https://doaj.org/article/50dcf12469e54fa0a565dbd44f19d4a0
Autor:
Kezheng Peng, Chenye Zeng, Yuqi Gao, Binliang Liu, Liyuan Li, Kang Xu, Yuemiao Yin, Ying Qiu, Mingkui Zhang, Fei Ma, Zhao Wang
Publikováno v:
Acta Pharmaceutica Sinica B, Vol 13, Iss 6, Pp 2680-2700 (2023)
Since the utilization of anthracyclines in cancer therapy, severe cardiotoxicity has become a major obstacle. The major challenge in treating cancer patients with anthracyclines is minimizing cardiotoxicity without compromising antitumor efficacy. He
Externí odkaz:
https://doaj.org/article/f226587f8e5c4faeb0b928e0fcde17e1