Zobrazeno 1 - 10
of 1 809
pro vyhledávání: '"antitumor agent"'
Autor:
Shunsuke Kondo, Yuki Katsuya, Kan Yonemori, Keiko Komuro, Masatoshi Sugeno, Toshio Kawata, Dana Ghiorghiu, Didier Meulendijks, Noboru Yamamoto
Publikováno v:
Cancer Treatment and Research Communications, Vol 39, Iss , Pp 100809- (2024)
Introduction: We aimed to assess the safety, pharmacokinetic profile, and antitumor activity of adavosertib monotherapy in Japanese patients with advanced solid tumors. Materials and methods: This was a single-center, open-label, phase I study with t
Externí odkaz:
https://doaj.org/article/c5e3b71ea3544fcba7e6ccf11b726a69
Autor:
Eman Zakaria Gomaa
Publikováno v:
Bulletin of the National Research Centre, Vol 46, Iss 1, Pp 1-11 (2022)
Abstract Background Halophiles are an excellent source of enzymes that are not only salt stable, but also can withstand and carry out reaction efficiently under extreme conditions. l-glutaminase has attracted much attention with respect to proposed a
Externí odkaz:
https://doaj.org/article/dd946cac3eac40b4aa918ff4cbb23a2b
Publikováno v:
Journal of Pharmaceutical Analysis, Vol 11, Iss 6, Pp 791-798 (2021)
Unsymmetrical bisacridines (UAs) are a novel potent class of antitumor-active therapeutics. A significant route of phase II drug metabolism is conjugation with glutathione (GSH), which can be non-enzymatic and/or catalyzed by GSH-dependent enzymes. T
Externí odkaz:
https://doaj.org/article/af970ca62e2d4b51a1bbec8871eb1181
Akademický článek
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Akademický článek
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Autor:
Ziling Xu, Pingfang Tian
Publikováno v:
Molecules, Vol 28, Iss 6, p 2761 (2023)
Aclacinomycin A (ACM-A) is an anthracycline antitumor agent widely used in clinical practice. The current industrial production of ACM-A relies primarily on chemical synthesis and microbial fermentation. However, chemical synthesis involves multiple
Externí odkaz:
https://doaj.org/article/98979de601344cd3903a739602d0f20b
Autor:
Hong Zhang, Tao Zhu, Ruoqiu Fu, Yang Peng, Peng Jing, Wenchun Xu, Hong Wang, Sijie Li, Zhaoche Shu, Yibing Yin, Xuemei Zhang
Publikováno v:
Molecular Therapy: Oncolytics, Vol 18, Iss , Pp 247-261 (2020)
Increasing evidence demonstrates that microorganisms and their products can modulate host responses to cancer therapies and contribute to tumor shrinkage via various mechanisms, including intracellular signaling pathways modulation and immunomodulati
Externí odkaz:
https://doaj.org/article/4188023051db40c2a2b651e83fa20939
Publikováno v:
Chinese Medicine, Vol 15, Iss 1, Pp 1-28 (2020)
Abstract Norcantharidin (NCTD) is a demethylated derivative of cantharidin, which is an anticancer active ingredient of traditional Chinese medicine, and is currently used clinically as a routine anti-cancer drug in China. Clarifying the anticancer e
Externí odkaz:
https://doaj.org/article/cf3b866181364dcea1c681242e081c1b
Publikováno v:
Pharmaceutics, Vol 14, Iss 11, p 2420 (2022)
A novel class of quinoxaline–arylfuran derivatives were designed, synthesized, and preliminarily evaluated for their antiproliferative activities in vitro against several cancer cell lines and normal cells. The representative derivative QW12 exerts
Externí odkaz:
https://doaj.org/article/42b203f5c16a410298664314bcaf02a9
Publikováno v:
Pharmaceutics, Vol 14, Iss 10, p 2104 (2022)
A series of novel naphthoquinone-furan-2-cyanoacryloyl hybrids were designed; they were synthesized and preliminarily evaluated for their anti-proliferative activities in vitro against several cancer cell lines and normal cells. The most potent compo
Externí odkaz:
https://doaj.org/article/b42dadcc3f1344af9ef274618d30b235