Selective Aurora A-TPX2 Interaction Inhibitors Have In Vivo Efficacy as Targeted Antimitotic Agents.

Autor: Stockwell SR; Medical Research Council Cancer Unit, University of Cambridge, Cambridge CB2 0XZ, U.K., Scott DE; Yusuf Hamied Department of Chemistry, University of Cambridge, Cambridge CB2 1EW, U.K., Fischer G; Department of Biochemistry, University of Cambridge, Cambridge CB2 1GA, U.K., Guarino E; Medical Research Council Cancer Unit, University of Cambridge, Cambridge CB2 0XZ, U.K., Rooney TPC; Yusuf Hamied Department of Chemistry, University of Cambridge, Cambridge CB2 1EW, U.K., Feng TS; Yusuf Hamied Department of Chemistry, University of Cambridge, Cambridge CB2 1EW, U.K., Moschetti T; Department of Biochemistry, University of Cambridge, Cambridge CB2 1GA, U.K., Srinivasan R; Yusuf Hamied Department of Chemistry, University of Cambridge, Cambridge CB2 1EW, U.K., Alza E; Yusuf Hamied Department of Chemistry, University of Cambridge, Cambridge CB2 1EW, U.K., Asteian A; Yusuf Hamied Department of Chemistry, University of Cambridge, Cambridge CB2 1EW, U.K., Dagostin C; Yusuf Hamied Department of Chemistry, University of Cambridge, Cambridge CB2 1EW, U.K., Alcaide A; Yusuf Hamied Department of Chemistry, University of Cambridge, Cambridge CB2 1EW, U.K., Rocaboy M; Department of Biochemistry, University of Cambridge, Cambridge CB2 1GA, U.K., Blaszczyk B; Department of Biochemistry, University of Cambridge, Cambridge CB2 1GA, U.K., Higueruelo A; Department of Biochemistry, University of Cambridge, Cambridge CB2 1GA, U.K., Wang X; Department of Biochemistry, University of Cambridge, Cambridge CB2 1GA, U.K., Rossmann M; Department of Biochemistry, University of Cambridge, Cambridge CB2 1GA, U.K., Perrior TR, Blundell TL; Department of Biochemistry, University of Cambridge, Cambridge CB2 1GA, U.K., Spring DR; Yusuf Hamied Department of Chemistry, University of Cambridge, Cambridge CB2 1EW, U.K., McKenzie G; Medical Research Council Cancer Unit, University of Cambridge, Cambridge CB2 0XZ, U.K., Abell C; Yusuf Hamied Department of Chemistry, University of Cambridge, Cambridge CB2 1EW, U.K., Skidmore J; Yusuf Hamied Department of Chemistry, University of Cambridge, Cambridge CB2 1EW, U.K., Venkitaraman AR; Medical Research Council Cancer Unit, University of Cambridge, Cambridge CB2 0XZ, U.K., Hyvönen M; Department of Biochemistry, University of Cambridge, Cambridge CB2 1GA, U.K.

Publikováno v: Journal of medicinal chemistry [J Med Chem] 2024 Sep 12; Vol. 67 (17), pp. 15521-15536. Date of Electronic Publication: 2024 Aug 27.

Oxindoline Containing Thiazolidine‐4‐one Tethered Triazoles Act as Antimitotic Agents by Targeting Microtubule Dynamics.

Autor: Shahjahan, S.¹ (AUTHOR), Naraharisetti, Lakshmi T.² (AUTHOR), Begum, Alia³ (AUTHOR), Yakkala, Prasanna A.⁴ (AUTHOR), Lakshmi Soukya, P.S.⁵ (AUTHOR), Godugu, Chandraiah² (AUTHOR), Begum, Sajeli A.⁵ (AUTHOR), Kamal, Ahmed^4,5 (AUTHOR) ahmedkamal@hyderabad.bits-pilani.ac.in

Publikováno v: ChemistrySelect. 5/3/2024, Vol. 9 Issue 17, p1-12. 12p.

Time-Lapse Imaging to Analyze Cell Fate in Response to Antimitotics.

Autor: Silva PMA; UNIPRO - Oral Pathology and Rehabilitation Research Unit, University Institute of Health Sciences (IUCS), Cooperativa de Ensino Superior Politécnico e Universitário (CESPU), Gandra, Portugal. patricia.silva@cespu.pt.; Associate Laboratory i4HB - Institute for Health and Bioeconomy, UCIBIO - Applied Molecular Biosciences Unit, Translational Toxicology Research Laboratory (1H-TOXRUN, IUCS-CESPU), University Institute of Health Sciences, CESPU, CRL, Gandra, Portugal. patricia.silva@cespu.pt., Silva JPN; UNIPRO - Oral Pathology and Rehabilitation Research Unit, University Institute of Health Sciences (IUCS), Cooperativa de Ensino Superior Politécnico e Universitário (CESPU), Gandra, Portugal., Pinto B; UNIPRO - Oral Pathology and Rehabilitation Research Unit, University Institute of Health Sciences (IUCS), Cooperativa de Ensino Superior Politécnico e Universitário (CESPU), Gandra, Portugal., Bousbaa H; UNIPRO - Oral Pathology and Rehabilitation Research Unit, University Institute of Health Sciences (IUCS), Cooperativa de Ensino Superior Politécnico e Universitário (CESPU), Gandra, Portugal. hassan.bousbaa@iucs.cespu.pt.

Publikováno v: Methods in molecular biology (Clifton, N.J.) [Methods Mol Biol] 2025; Vol. 2874, pp. 115-126.

Novel substituted 5-methyl-4-acylaminoisoxazoles as antimitotic agents: Evaluation of selectivity to LNCaP cancer cells.

Autor: Sadovnikov KS; Department of Chemistry, Lomonosov Moscow State University, Moscow, Russian Federation., Vasilenko DA; Department of Chemistry, Lomonosov Moscow State University, Moscow, Russian Federation., Gracheva YA; Department of Chemistry, Lomonosov Moscow State University, Moscow, Russian Federation., Zefirov NA; Department of Chemistry, Lomonosov Moscow State University, Moscow, Russian Federation., Radchenko EV; Department of Chemistry, Lomonosov Moscow State University, Moscow, Russian Federation., Palyulin VA; Department of Chemistry, Lomonosov Moscow State University, Moscow, Russian Federation., Grishin YK; Department of Chemistry, Lomonosov Moscow State University, Moscow, Russian Federation., Vasilichin VA; Department of Chemistry, Lomonosov Moscow State University, Moscow, Russian Federation., Shtil AA; Department of Chemistry, Lomonosov Moscow State University, Moscow, Russian Federation.; Blokhin National Medical Research Center of Oncology, Moscow, Russian Federation., Shevtsov PN; Institute of Physiologically Active Compounds, Chernogolovka MR, Russian Federation., Shevtsova EF; Institute of Physiologically Active Compounds, Chernogolovka MR, Russian Federation., Kuznetsova TS; Department of Chemistry, Lomonosov Moscow State University, Moscow, Russian Federation., Kuznetsov SA; Institute of Biological Sciences, Cell Biology and Biosystems Technology, University of Rostock, Rostock, Germany., Bunev AS; Medicinal Chemistry Center, Togliatti State University, Togliatti, Russian Federation., Zefirova ON; Department of Chemistry, Lomonosov Moscow State University, Moscow, Russian Federation., Milaeva ER; Department of Chemistry, Lomonosov Moscow State University, Moscow, Russian Federation., Averina EB; Department of Chemistry, Lomonosov Moscow State University, Moscow, Russian Federation.

Publikováno v: Archiv der Pharmazie [Arch Pharm (Weinheim)] 2022 May; Vol. 355 (5), pp. e2100425. Date of Electronic Publication: 2022 Feb 01.

Development of hydrazide hydrazone-tethered combretastatin-oxindole derivatives as antimitotic agents

Autor: Bora, Darshana ^a, Sharma, Anamika ^b, John, Stephy Elza ^a, Shankaraiah, Nagula ^{a, ⁎}

Publikováno v: In Journal of Molecular Structure 5 March 2023 1275