Zobrazeno 1 - 10
of 12 313
pro vyhledávání: '"anticancer agents"'
Autor:
Hanaa Mohammed, Mustafa M. Karhib, Karrar Sabah Jaafar Al-Fahad, Atef Mohamed Atef, Areej Eskandrani, Amira Abd-elfattah Darwish, Ahmed Abdallah Sary, Bassma H. Elwakil, Basant A. Bakr, Ahmed M. Eldrieny
Publikováno v:
Scientific Reports, Vol 14, Iss 1, Pp 1-15 (2024)
Abstract Breast cancer is among the highest morbidity and mortality rates in women around the world. In the present investigation we aimed to synthesis novel nanosystem combining two naturally important anticancer agents with different mechanism of a
Externí odkaz:
https://doaj.org/article/5d59be275fb64115a975cabf4122806f
Autor:
Barbara Herlah, Tjaša Goričan, Nika Strašek Benedik, Simona Golič Grdadolnik, Izidor Sosič, Andrej Perdih
Publikováno v:
Computational and Structural Biotechnology Journal, Vol 23, Iss , Pp 2995-3018 (2024)
The 4,6-substituted-1,3,5-triazin-2(1H)-ones are promising inhibitors of human DNA topoisomerase IIα. To further develop this chemical class targeting the enzyme´s ATP binding site, the triazin-2(1H)-one substitution position 6 was optimized. Inspi
Externí odkaz:
https://doaj.org/article/a2d96ff88e0843fbb8c7a452b3c05308
Autor:
Samin A. Shaikh, Satish N. Wakchaure, Shivaji R. Labhade, Raju R. Kale, Rajasekhar R. Alavala, Santosh S. Chobe, Kamlesh S. Jain, Hrishikesh S. Labhade, Dipak D. Bhanushali
Publikováno v:
BMC Chemistry, Vol 18, Iss 1, Pp 1-11 (2024)
Abstract In an attempt to develop potent anti-cancer agents, a new 1,3,4-substituted-thiadiazole derivatives (8b-g), starting from 4-substituted-thiazol-2-chloroacetamides (4b-g), were synthesized and evaluated for their cytotoxic effects on multiple
Externí odkaz:
https://doaj.org/article/173ecd3cf016493faab9b2b2c9bd09bf
Autor:
Ghada Abd-Elmonsef Mahmoud, Abo bakr Abdel Shakor, Nahla A. Kamal-Eldin, Abdel-Naser A. Zohri
Publikováno v:
BMC Microbiology, Vol 24, Iss 1, Pp 1-19 (2024)
Abstract Kojic acid is a wonderful fungal secondary metabolite that has several applications in the food, medical, and agriculture sectors. Many human diseases become resistant to normal antibiotics and normal treatments. We need to search for altern
Externí odkaz:
https://doaj.org/article/62a0dd2aec3b4aad81abf9029c378be4
Publikováno v:
Al-SalamJournal for Medical Science, Vol 4, Iss 1 (2024)
This review sums up the developments in the biological activity of tetrazole active derivatives in recent days. Some of the deliberated derivatives of tetrazole are at present actively scientifically studied; some of them have biological activity tha
Externí odkaz:
https://doaj.org/article/639d677c74cf4f5a8ab271fe73f7fff2
Autor:
Khalida I. Noel
Publikováno v:
Siriraj Medical Journal, Vol 76, Iss 8 (2024)
Oxidative stress is a defense mechanism that occurs when there is an imbalance between the production of reactive metabolites and free radicals and the antioxidants' ability to eliminate them. Reactive metabolites are free radicals referred to as oxi
Externí odkaz:
https://doaj.org/article/4c5d0dea493c4126925137d907984509
Autor:
Gregorio Peron, Andrea Mastinu, Sheila I. Peña-Corona, Hector Hernández-Parra, Gerardo Leyva-Gómez, Daniela Calina, Javad Sharifi-Rad
Publikováno v:
Biomedicine & Pharmacotherapy, Vol 177, Iss , Pp 117047- (2024)
Cancer remains a leading cause of death, with increasing incidence. Conventional treatments offer limited efficacy and cause significant side effects, hence novel drugs with improved pharmacological properties and safety are required. Silvestrol (SLV
Externí odkaz:
https://doaj.org/article/7ef6e761d8ae406d943ba45da9be4e39
Autor:
Sridhar Goud Nerella
Publikováno v:
European Journal of Medicinal Chemistry Reports, Vol 11, Iss , Pp 100170- (2024)
Galectin-1 (gal-1) emerges as a potential biomarker for cancer diagnosis, prognosis, and therapy. Gal-1 plays a pivotal role in multiple stages of tumor progression, encompassing tumor transformation, tumor cell adhesion and migration, angiogenesis,
Externí odkaz:
https://doaj.org/article/aeba2c4fd2b24b508df7aeeacc205831
Autor:
Rahnuma Tabassum, Sarkar M.A. Kawsar, Asraful Alam, Supriyo Saha, Anowar Hosen, Imtiaj Hasan, Prinsa, Mohammed Chalkha
Publikováno v:
Chemical Physics Impact, Vol 9, Iss , Pp 100724- (2024)
Nucleoside derivatives are essential to medicinal chemistry because they provide biologically active drugs. A 5´-O-palmitoyl derivative (2) was obtained by directly treating cytidine (1) with palmitoyl chloride. New antimicrobial compounds were deve
Externí odkaz:
https://doaj.org/article/0f30454471dd423dbdd510b0a9f8acb2
Autor:
Maria Benavides
Publikováno v:
Results in Chemistry, Vol 8, Iss , Pp 101607- (2024)
Structural, electronic, and vibrational spectroscopic analysis using DFT/B3LYPD with LanL2DZ and SDD basis of two novel cationic gold(I) complexes with potential anticancer application exhibiting intramolecular aurophilic Au···H–N interactions,
Externí odkaz:
https://doaj.org/article/10cc26de041f4880858cbfe6afac9bb8