Zobrazeno 1 - 10
of 270
pro vyhledávání: '"antibody-secreting cell"'
Autor:
Ana C. Londoño, Carlos A. Mora
Publikováno v:
F1000Research, Vol 10 (2023)
A clear understanding of the origin and role of the different subtypes of the B cell lineage involved in the activity or remission of multiple sclerosis (MS) is important for the treatment and follow-up of patients living with this disease. B cells,
Externí odkaz:
https://doaj.org/article/46da7f39d19a49ef8b011725244c8301
Akademický článek
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Autor:
Carlos Castrillon, Lea Simoni, Theo van den Broek, Cees van der Poel, Elliot H Akama-Garren, Minghe Ma, Michael C Carroll
Publikováno v:
eLife, Vol 12 (2023)
Affinity matured self-reactive antibodies are found in autoimmune diseases like systemic lupus erythematous. Here, we used fate-mapping reporter mice and single-cell transcriptomics coupled to antibody repertoire analysis to characterize the post-ger
Externí odkaz:
https://doaj.org/article/89c2971e118943a3a05cb88795fde559
Autor:
KimAnh Trang Pioli, Peter Dion Pioli
Publikováno v:
Frontiers in Immunology, Vol 14 (2023)
Antibody-secreting cells are essential contributors to the humoral response. This is due to multiple factors which include: 1) the ability to secrete thousands of antibodies per second, 2) the ability to regulate the immune response and 3) the potent
Externí odkaz:
https://doaj.org/article/74219615d826475aa0b9e9f97d5e455f
Autor:
Niels JM Verstegen, Sabrina Pollastro, Peter-Paul A Unger, Casper Marsman, George Elias, Tineke Jorritsma, Marij Streutker, Kevin Bassler, Kristian Haendler, Theo Rispens, Joachim L Schultze, Anja ten Brinke, Marc Beyer, S Marieke van Ham
Publikováno v:
eLife, Vol 12 (2023)
Differentiation of B cells into antibody-secreting cells (ASCs) is a key process to generate protective humoral immunity. A detailed understanding of the cues controlling ASC differentiation is important to devise strategies to modulate antibody form
Externí odkaz:
https://doaj.org/article/37ca614a337b4cb2ad7529e2d1b73933
Autor:
Patrick Daum, Shannon R. Ottmann, Julia Meinzinger, Sebastian R. Schulz, Joana Côrte-Real, Manuela Hauke, Edith Roth, Wolfgang Schuh, Dirk Mielenz, Hans-Martin Jäck, Katharina Pracht
Publikováno v:
Frontiers in Immunology, Vol 13 (2022)
We have previously shown that the microRNA (miRNA) processor complex consisting of the RNAse Drosha and the DiGeorge Critical Region (DGCR) 8 protein is essential for B cell maturation. To determine whether miRNA processing is required to initiate T
Externí odkaz:
https://doaj.org/article/8b042029acb9441b9ad755d9568f3a0c
Autor:
Jana Koers, Casper Marsman, Juulke Steuten, Simon Tol, Ninotska I. L. Derksen, Anja ten Brinke, S. Marieke van Ham, Theo Rispens
Publikováno v:
Frontiers in Immunology, Vol 13 (2022)
The generation of high-affinity antibodies requires an efficient germinal center (GC) response. As differentiating B cells cycle between GC dark and light zones they encounter different oxygen pressures (pO2). However, it is essentially unknown if an
Externí odkaz:
https://doaj.org/article/5c4701492b4443feb08d74297f0074cc
Autor:
David J Turner, Alexander Saveliev, Fiamma Salerno, Louise S Matheson, Michael Screen, Hannah Lawson, David Wotherspoon, Kamil R Kranc, Martin Turner
Publikováno v:
eLife, Vol 11 (2022)
To identify roles of RNA binding proteins (RBPs) in the differentiation or survival of antibody secreting plasma cells we performed a CRISPR/Cas9 knockout screen of 1213 mouse RBPs for their ability to affect proliferation and/or survival, and the ab
Externí odkaz:
https://doaj.org/article/82d0b3c9007147978c12bb01398d56b3
Autor:
Matteo Broketa, Pierre Bruhns
Publikováno v:
Frontiers in Immunology, Vol 12 (2022)
Antibody-secreting cells (ASC), plasmablasts and plasma cells, are terminally differentiated B cells responsible for large-scale production and secretion of antibodies. ASC are derived from activated B cells, which may differentiate extrafollicularly
Externí odkaz:
https://doaj.org/article/3e762299d8d84b90adb247ebdfd8946b
Autor:
Peter Szodoray, Tor Kristian Andersen, Julia Heinzelbecker, John F. Imbery, Peter C. Huszthy, Stephanie M. Stanford, Bjarne Bogen, Ole B. Landsverk, Nunzio Bottini, Anders Tveita, Ludvig A. Munthe, Britt Nakken
Publikováno v:
Cell Reports, Vol 36, Iss 6, Pp 109525- (2021)
Summary: Humoral immunity relies on the efficient differentiation of memory B cells (MBCs) into antibody-secreting cells (ASCs). T helper (Th) signals upregulate B cell receptor (BCR) signaling by potentiating Src family kinases through increasing CD
Externí odkaz:
https://doaj.org/article/eb782f741c90461f80cc29c4bb22a13b