Zobrazeno 1 - 10
of 154
pro vyhledávání: '"antibody-gene"'
Autor:
Kevin Hollevoet, Debby Thomas, Griet Compernolle, Giles Vermeire, Elien De Smidt, Stéphanie De Vleeschauwer, Trevor R. F. Smith, Paul D. Fisher, Maarten Dewilde, Nick Geukens, Paul Declerck
Publikováno v:
Frontiers in Oncology, Vol 12 (2022)
DNA-encoded delivery and in vivo expression of antibody therapeutics presents an innovative alternative to conventional protein production and administration, including for cancer treatment. To support clinical translation, we evaluated this approach
Externí odkaz:
https://doaj.org/article/cb5aeebb46eb45eda1b24488bb84672d
Publikováno v:
Pharmaceutics, Vol 15, Iss 4, p 1160 (2023)
DNA-based antibody therapy seeks to administer the encoding nucleotide sequence rather than the antibody protein. To further improve the in vivo monoclonal antibody (mAb) expression, a better understanding of what happens after the administration of
Externí odkaz:
https://doaj.org/article/e3116caad94d40e696840b5c399edd9d
Autor:
Tatsuya Yamazaki, Mrityunjoy Biswas, Kouyu Kosugi, Maria Nagashima, Masanori Inui, Susumu Tomono, Hidekazu Takagi, Isao Ichimonji, Fumiaki Nagaoka, Akira Ainai, Hideki Hasegawa, Joe Chiba, Sachiko Akashi-Takamura
Publikováno v:
Frontiers in Immunology, Vol 11 (2020)
Radioprotective 105 (RP105) (also termed CD180) is an orphan and unconventional Toll-like receptor (TLR) that lacks an intracellular signaling domain. The agonistic anti-RP105 monoclonal antibody (mAb) can cross-link RP105 on B cells, resulting in th
Externí odkaz:
https://doaj.org/article/349c2f98b4804ec392860fc398516433
Autor:
Allen Lin, Alejandro B. Balazs
Publikováno v:
Retrovirology, Vol 15, Iss 1, Pp 1-17 (2018)
Abstract Vectored gene delivery of HIV-1 broadly neutralizing antibodies (bNAbs) using recombinant adeno-associated virus (rAAV) is a promising alternative to conventional vaccines for preventing new HIV-1 infections and for therapeutically suppressi
Externí odkaz:
https://doaj.org/article/12ae665b68204643978a168311d4a162
Autor:
Chasity D. Andrews, Yang Luo, Ming Sun, Jian Yu, Arthur J. Goff, Pamela J. Glass, Neal N. Padte, Yaoxing Huang, David D. Ho
Publikováno v:
Molecular Therapy: Methods & Clinical Development, Vol 7, Iss C, Pp 74-82 (2017)
Monoclonal antibodies (mAbs) have wide clinical utility, but global access is limited by high costs and impracticalities associated with repeated passive administration. Here, we describe an optimized electroporation-based DNA gene transfer platform
Externí odkaz:
https://doaj.org/article/ac310ef9b08343a4956a922f3c9d2077
Akademický článek
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Autor:
Johanna Reul, Janina Frisch, Christine E. Engeland, Frederic B. Thalheimer, Jessica Hartmann, Guy Ungerechts, Christian J. Buchholz
Publikováno v:
Frontiers in Oncology, Vol 9 (2019)
Immune checkpoint inhibitors (ICIs) can block distinct receptors on T cells or tumor cells thus preventing T cell inactivation and tumor immune escape. While the clinical response to treatment with ICIs in cancer patients is impressive, this therapy
Externí odkaz:
https://doaj.org/article/c9b2651adab048cc8ecea4b5e41846c3
Akademický článek
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Publikováno v:
Viruses, Vol 6, Iss 2, Pp 428-447 (2014)
Despite tremendous efforts over the course of many years, the quest for an effective HIV vaccine by the classical method of active immunization remains largely elusive. However, two recent studies in mice and macaques have now demonstrated a new stra
Externí odkaz:
https://doaj.org/article/47bfacd6632341c4bd71453918481e57
Publikováno v:
Vaccines, Vol 6, Iss 3, p 35 (2018)
Hemagglutinin (HA) of influenza virus is a major target for vaccines. HA initiates the internalization of the virus into the host cell by binding to host sialic acid receptors; therefore, inhibition of HA can significantly prevent influenza virus inf
Externí odkaz:
https://doaj.org/article/73299d38a34441b6852465b72ceb1276