Výsledky vyhledávání - "antibody binding"

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ANTIPASTI: interpretable prediction of antibody binding affinity exploiting Normal Modes and Deep Learning

Autor: Michalewicz, Kevin, Barahona, Mauricio, Bravi, Barbara

The high binding affinity of antibodies towards their cognate targets is key to eliciting effective immune responses, as well as to the use of antibodies as research and therapeutic tools. Here, we propose ANTIPASTI, a Convolutional Neural Network mo

Externí odkaz: http://arxiv.org/abs/2410.01523

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AttABseq: an attention-based deep learning prediction method for antigen–antibody binding affinity changes based on protein sequences.

Autor: Jin, Ruofan^1,2 (AUTHOR), Ye, Qing¹ (AUTHOR), Wang, Jike¹ (AUTHOR), Cao, Zheng³ (AUTHOR), Jiang, Dejun¹ (AUTHOR), Wang, Tianyue¹ (AUTHOR), Kang, Yu¹ (AUTHOR), Xu, Wanting¹ (AUTHOR), Hsieh, Chang-Yu¹ (AUTHOR) kimhsieh@zju.edu.cn, Hou, Tingjun¹ (AUTHOR) kimhsieh@zju.edu.cn

Publikováno v: Briefings in Bioinformatics. Jul2024, Vol. 25 Issue 4, p1-14. 14p.

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Dynamics of antibody binding and neutralization during viral infection

Autor: Chen, Zhenying, Ahmed, Hasan, Hirst, Cora, Antia, Rustom

In vivo in infection, virions are constantly produced and die rapidly. In contrast, most antibody binding assays do not include such features. Motivated by this, we considered virions with n=100 binding sites in simple mathematical models with and wi

Externí odkaz: http://arxiv.org/abs/2405.09647

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Measures of Population Immunity Can Predict the Dominant Clade of Influenza A (H3N2) in the 2017–2018 Season and Reveal Age‐Associated Differences in Susceptibility and Antibody‐Binding Specificity.

Autor: Kim, Kangchon¹ (AUTHOR) kangchonsara@gmail.com, Vieira, Marcos C.¹ (AUTHOR), Gouma, Sigrid² (AUTHOR), Weirick, Madison E.² (AUTHOR), Hensley, Scott E.² (AUTHOR), Cobey, Sarah¹ (AUTHOR)

Publikováno v: Influenza & Other Respiratory Viruses. Nov2024, Vol. 18 Issue 11, p1-13. 13p.

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Comprehensive Analysis of Cetuximab Critical Quality Attributes: Impact of Handling on Antigen-Antibody Binding.

Autor: Torres-García, Alicia^1,2 (AUTHOR) alicia.torres@genyo.es, Torrente-López, Anabel^2,3 (AUTHOR) anabeltl@ugr.es, Hermosilla, Jesús^2,3 (AUTHOR) jesushf@ugr.es, Hernández, Amparo³ (AUTHOR), Salmerón-García, Antonio^2,4 (AUTHOR) antonio.salmeron.sspa@juntadeandalucia.es, Cabeza, José^2,4 (AUTHOR) jose.cabeza.sspa@juntadeandalucia.es, Navas, Natalia^2,3 (AUTHOR) natalia@ugr.es

Publikováno v: Pharmaceutics. Sep2024, Vol. 16 Issue 9, p1222. 24p.

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