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pro vyhledávání: '"antibody affinity maturation"'
Akademický článek
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Autor:
Huiyu Cai, Zuobai Zhang, Mingkai Wang, Bozitao Zhong, Quanxiao Li, Yuxuan Zhong, Yanling Wu, Tianlei Ying, Jian Tang
Publikováno v:
Nature Communications, Vol 15, Iss 1, Pp 1-14 (2024)
Abstract Increasing the binding affinity of an antibody to its target antigen is a crucial task in antibody therapeutics development. This paper presents a pretrainable geometric graph neural network, GearBind, and explores its potential in in silico
Externí odkaz:
https://doaj.org/article/326a856cdb144984ae87d5a5ddcdd218
Autor:
Cai H; BioGeometry, Beijing, China.; Mila-Québec AI Institute, Montréal, QC, Canada.; Department of Computer Science and Operations Research, Université de Montréal, Montréal, QC, Canada., Zhang Z; Mila-Québec AI Institute, Montréal, QC, Canada.; Department of Computer Science and Operations Research, Université de Montréal, Montréal, QC, Canada., Wang M; Shanghai Engineering Research Center for Synthetic Immunology, Fudan University, Shanghai, China.; MOE/NHC/CAMS Key Laboratory of Medical Molecular Virology, Shanghai Frontiers Science Center of Pathogenic Microorganisms and Infection, Shanghai Institute of Infectious Disease and Biosecurity, School of Basic Medical Sciences, Fudan University, Shanghai, China., Zhong B; Mila-Québec AI Institute, Montréal, QC, Canada.; Department of Computer Science and Operations Research, Université de Montréal, Montréal, QC, Canada., Li Q; Shanghai Engineering Research Center for Synthetic Immunology, Fudan University, Shanghai, China.; MOE/NHC/CAMS Key Laboratory of Medical Molecular Virology, Shanghai Frontiers Science Center of Pathogenic Microorganisms and Infection, Shanghai Institute of Infectious Disease and Biosecurity, School of Basic Medical Sciences, Fudan University, Shanghai, China., Zhong Y; Shanghai Engineering Research Center for Synthetic Immunology, Fudan University, Shanghai, China.; MOE/NHC/CAMS Key Laboratory of Medical Molecular Virology, Shanghai Frontiers Science Center of Pathogenic Microorganisms and Infection, Shanghai Institute of Infectious Disease and Biosecurity, School of Basic Medical Sciences, Fudan University, Shanghai, China., Wu Y; Shanghai Engineering Research Center for Synthetic Immunology, Fudan University, Shanghai, China. yanlingwu@fudan.edu.cn.; MOE/NHC/CAMS Key Laboratory of Medical Molecular Virology, Shanghai Frontiers Science Center of Pathogenic Microorganisms and Infection, Shanghai Institute of Infectious Disease and Biosecurity, School of Basic Medical Sciences, Fudan University, Shanghai, China. yanlingwu@fudan.edu.cn., Ying T; Shanghai Engineering Research Center for Synthetic Immunology, Fudan University, Shanghai, China. tlying@fudan.edu.cn.; MOE/NHC/CAMS Key Laboratory of Medical Molecular Virology, Shanghai Frontiers Science Center of Pathogenic Microorganisms and Infection, Shanghai Institute of Infectious Disease and Biosecurity, School of Basic Medical Sciences, Fudan University, Shanghai, China. tlying@fudan.edu.cn., Tang J; BioGeometry, Beijing, China. tangjian@biogeom.com.; Mila-Québec AI Institute, Montréal, QC, Canada. tangjian@biogeom.com.; Department of Decision Sciences, HEC Montréal, Montréal, QC, Canada. tangjian@biogeom.com.
Publikováno v:
Nature communications [Nat Commun] 2024 Oct 07; Vol. 15 (1), pp. 8675. Date of Electronic Publication: 2024 Oct 07.
Autor:
Huiyu Cai, Zuobai Zhang, Mingkai Wang, Bozitao Zhong, Quanxiao Li, Yuxuan Zhong, Yanling Wu, Tianlei Ying, Jian Tang
Publikováno v:
Nature Communications, Vol 15, Iss 1, Pp 1-1 (2024)
Externí odkaz:
https://doaj.org/article/98460e236461463ea1eeee6f57b32f88
In response to pathogens, the adaptive immune system generates specific antibodies that bind and neutralize foreign antigens. Understanding the composition of an individual's immune repertoire can provide insights into this process and reveal potenti
Externí odkaz:
http://arxiv.org/abs/2112.07782
Autor:
Qu, Baole1,2 (AUTHOR), Zhao, Yun1,2 (AUTHOR), An, Lili1 (AUTHOR), Hang, Haiying1,2 (AUTHOR) hh91@ibp.ac.cn
Publikováno v:
Applied Microbiology & Biotechnology. Apr2023, Vol. 107 Issue 7/8, p2661-2670. 10p.
Antibody therapeutics has been extensively studied in drug discovery and development within the past decades. One increasingly popular focus in the antibody discovery pipeline is the optimization step for therapeutic leads. Both traditional methods a
Externí odkaz:
http://arxiv.org/abs/2103.03724
Publikováno v:
Phys. Rev. E 103, 052413 (2021)
Affinity Maturation (AM) is the process through which the immune system is able to develop potent antibodies against new pathogens it encounters, and is at the base of the efficacy of vaccines. At its core AM is analogous to a Darwinian evolutionary
Externí odkaz:
http://arxiv.org/abs/2010.11580
Publikováno v:
BioEssays, 2021
The affinity of antibodies (Abs) produced in vivo for their target antigens (Ags) is typically well below the maximum affinity possible. Nearly 25 years ago, Foote and Eisen explained how an 'affinity ceiling' could arise from constraints associated
Externí odkaz:
http://arxiv.org/abs/2002.02642
Autor:
Tang, Juanjie, Grubbs, Gabrielle, Lee, Youri, Huang, Chang, Ravichandran, Supriya, Forgacs, David, Golding, Hana, Ross, Ted M, Khurana, Surender
Publikováno v:
In eBioMedicine December 2021 74