Zobrazeno 1 - 10
of 6 409
pro vyhledávání: '"antibody‐dependent cell‐mediated cytotoxicity"'
Autor:
Yinjie Liang, Junjia Guo, Zhen Li, Shiyuan Liu, Ting Zhang, Shucai Sun, Funa Lu, Yuqian Zhai, Wenling Wang, Chuanyi Ning, Wenjie Tan
Publikováno v:
Biosafety and Health, Vol 6, Iss 3, Pp 178-185 (2024)
The matrix protein 2 (M2) is a preferred target for developing a universal vaccine against the influenza A virus (IAV). This study aimed to develop a method for assessing antibody-dependent cell-mediated cytotoxicity (ADCC) associated with M2-based i
Externí odkaz:
https://doaj.org/article/11ff126d9fd04d37aeafc2ce2f986a51
Publikováno v:
eLife, Vol 13 (2024)
Both endogenous antibodies and a subset of antibody therapeutics engage Fc gamma receptor (FcγR)IIIa/CD16a to stimulate a protective immune response. Increasing the FcγRIIIa/IgG1 interaction improves the immune response and thus represents a strate
Externí odkaz:
https://doaj.org/article/fa1b98bab8f749aba01b8fcf353de5c5
Autor:
Jennifer L. Schwedler, Maxwell A. Stefan, Christine E. Thatcher, Peter R. McIlroy, Anupama Sinha, Ashlee M. Phillips, Christopher A. Sumner, Colleen M. Courtney, Christina Y. Kim, Dina R. Weilhammer, Brooke Harmon
Publikováno v:
mAbs, Vol 16, Iss 1 (2024)
ABSTRACTThe development of specific, safe, and potent monoclonal antibodies (Abs) has led to novel therapeutic options for infectious disease. In addition to preventing viral infection through neutralization, Abs can clear infected cells and induce i
Externí odkaz:
https://doaj.org/article/41cb4663916447a9b561b48ff9e50a25
Autor:
Svetlana V. Kalinichenko, Lama Ramadan, Natalia A. Kruglova, Konstantin I. Balagurov, Marina I. Lukashina, Dmitriy V. Mazurov, Mikhail V. Shepelev
Publikováno v:
Biology, Vol 13, Iss 9, p 675 (2024)
Peptides from heptad repeat (HR1 and HR2) regions of gp41 are effective inhibitors of HIV-1 entry that block the fusion of viral and cellular membranes, but the generation of antibodies highly specific for these peptides is challenging. We have previ
Externí odkaz:
https://doaj.org/article/5bf65ce261624465a2e1c13ae279ed1f
Autor:
A.V. Serritella, N.K.S. Grewal, B. Peterson, K. Arndt, D.D. Gaudio, P. Liu, A. Shergill, B. Polite, H.L. Kindler, D.V.T. Catenacci, C.Y. Liao
Publikováno v:
ESMO Gastrointestinal Oncology, Vol 2, Iss , Pp 100012- (2023)
Background: Immunoglobulin G1 (IgG1) monoclonal antibodies (mAbs), such as trastuzumab and ramucirumab, are utilized in advanced gastroesophageal adenocarcinoma (aGEA). The important mechanism of mAb therapeutic effect is engagement by natural killer
Externí odkaz:
https://doaj.org/article/ce98806709244b9ba25a9270e7def685
Publikováno v:
Zhongguo shuxue zazhi, Vol 36, Iss 2, Pp 121-125 (2023)
Objective To establish a method for determinating the antigen-dependent cell-mediated cytotoxicity (ADCC) of human immunoglobulin (pH4)for intravenous injection (IVIG) on luciferase reporter gene-modified cell assay. Methods As effector cells, Jurkat
Externí odkaz:
https://doaj.org/article/23fd35dc0a1942818abdb9ce53b8077c
Publikováno v:
Virulence, Vol 13, Iss 1, Pp 258-296 (2022)
Hepatitis B virus (HBV) is a hepatotropic virus and an important human pathogen. There are an estimated 296 million people in the world that are chronically infected by this virus, and many of them will develop severe liver diseases including hepatit
Externí odkaz:
https://doaj.org/article/e8d69ca0bcfe417bbc53ccf2a63927ac
Publikováno v:
Journal of Immunotoxicology, Vol 19, Iss 1, Pp 109-116 (2022)
The potential for effector functions of therapeutic antibodies, including antibody-dependent cell-mediated cytotoxicity (ADCC), is a biological activity of interest for characterization, regardless of if ADCC is an intended primary pharmacological ef
Externí odkaz:
https://doaj.org/article/9f657dbea76a49e2b12de3ca8be1a202
Akademický článek
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Publikováno v:
Pharmaceutical Fronts, Vol 04, Iss 03, Pp e197-e206 (2022)
Many studies have confirmed that the human poliovirus receptor (PVR; CD155) is related to tumor cell migration, invasion, and thus tumor progression. A PVR receptor binds its ligand T cell Ig and the ITIM domain (TIGIT) to inhibit the function of T a
Externí odkaz:
https://doaj.org/article/65215551192c4633a7c7d86c9025bfc7