Zobrazeno 1 - 10
of 372
pro vyhledávání: '"antibiotic synergy"'
Publikováno v:
Frontiers in Pharmacology, Vol 15 (2024)
Thanatin is a β-hairpin antimicrobial peptide cyclised by a single disulfide bond that has shown potent broad-spectrum activity towards bacterial and fungal pathogens. Towards Gram-negative species, thanatin acts both by forming trans-membranal pore
Externí odkaz:
https://doaj.org/article/287bc94011e1465898693298a480c6ed
Autor:
Kunhao Qin, Xing Shi, Kai Yang, Qiuqing Xu, Fuxing Wang, Senxiong Chen, Tingting Xu, Jinquan Liu, Wangrong Wen, Rongchang Chen, Zheng Liu, Li Cui, Kai Zhou
Publikováno v:
mBio, Vol 15, Iss 10 (2024)
ABSTRACT Phage-antibiotic synergy (PAS) represents a superior treatment strategy for pathogen infections with less probability of resistance development. Here, we aim to understand the molecular mechanism by which PAS suppresses resistance in terms o
Externí odkaz:
https://doaj.org/article/de4556d2ac9c42aa8c7660d22110c205
Autor:
Isaac P. Miller, Alma G. Laney, Geoffrey Zahn, Brock J. Sheehan, Kiara V. Whitley, Ruhul H. Kuddus
Publikováno v:
Frontiers in Microbiology, Vol 15 (2024)
BackgroundKlebsiella quasipneumoniae (previously known as K. pneumoniae K6) strains are among the multidrug-resistant hypervirulent bacterial pathogens. Phage therapy can help treat infections caused by such pathogens. Here we report some aspects of
Externí odkaz:
https://doaj.org/article/0a56b316464c41c7909c6b6d867370f8
Publikováno v:
Scientific Reports, Vol 14, Iss 1, Pp 1-11 (2024)
Abstract Phage-antibiotic combinations to treat bacterial infections are gaining increased attention due to the synergistic effects often observed when applying both components together. Most studies however focus on a single pathogen, although in ma
Externí odkaz:
https://doaj.org/article/ac2b7be2c4ed405a8c5c99629765a521
Publikováno v:
mSystems, Vol 9, Iss 9 (2024)
ABSTRACT The global rise of antibiotic resistance has renewed interest in phage therapy, as an alternative to antibiotics to eliminate multidrug-resistant (MDR) bacterial pathogens. However, optimizing the broad-spectrum efficacy of phage therapy rem
Externí odkaz:
https://doaj.org/article/109b69bca9d64449b8f0964dcc74a2ae
Autor:
Sattar Taheri-Araghi
Publikováno v:
Frontiers in Microbiology, Vol 15 (2024)
Antibiotic resistance is a growing global problem that requires innovative therapeutic approaches and strategies for administering antibiotics. One promising approach is combination therapy, in which two or more drugs are combined to combat an infect
Externí odkaz:
https://doaj.org/article/5d27beb381364d61aab178b6bec8552c
Autor:
Olufunke Olufunmilola Olorundare, Nikita Zrelovs, Dennis Kabantiyok, Karina Svanberga, Juris Jansons, Andris Kazaks, Godwin Ojonugwa Agada, Chibuzor Gerald Agu, Oluwatoyin Ruth Morenikeji, Ogundeji Alice Oluwapelumi, Thomas Dung, Shedrach Benjamin Pewan
Publikováno v:
Antibiotics, Vol 13, Iss 11, p 1006 (2024)
Pseudomonas aeruginosa is a bacteria responsible for many hospital-acquired infections. Phages are promising alternatives for treating P. aeruginosa infections, which are often intrinsically resistant. The combination of phage and antibiotics in clea
Externí odkaz:
https://doaj.org/article/005f723a611f44aeb642960940e86bc4
Publikováno v:
mBio, Vol 15, Iss 6 (2024)
ABSTRACT A recent demonstration of synergy between a temperate phage and the antibiotic ciprofloxacin suggested a scalable approach to exploiting temperate phages in therapy, termed temperate phage-antibiotic synergy, which specifically interacted wi
Externí odkaz:
https://doaj.org/article/f800b55c5cfe47f08f94b2716dc78026
Publikováno v:
Frontiers in Cellular and Infection Microbiology, Vol 14 (2024)
Antibiotic drug combination therapy is critical for the successful treatment of infections caused by multidrug resistant pathogens. We investigated the efficacy of β-lactam and β-lactam/β-lactamase inhibitor combinations with other antibiotics, ag
Externí odkaz:
https://doaj.org/article/889eb318d7c54984b634a5626c15eed3
Publikováno v:
Frontiers in Pharmacology, Vol 15 (2024)
Introduction: The emergence of antibiotic resistance is a significant challenge in the treatment of bacterial infections, particularly in patients in the intensive care unit (ICU). Phage-antibiotic combination therapy is now being utilized as a prefe
Externí odkaz:
https://doaj.org/article/0ac0417b64c441f98180ff8462a6c7d5