Zobrazeno 1 - 10
of 376
pro vyhledávání: '"antibiotic adjuvant"'
Publikováno v:
Drug Design, Development and Therapy, Vol Volume 18, Pp 3811-3824 (2024)
Chuanjiang Dong,1,* Yueqing Wang,2,3,* Yi Cai,4,* Yuhuang Wu,2,3 Wei Chen,2,3 Lu Wang,2,3 Xiaowen Liu,2 Lili Zou,2,3 Jun Wang5 1Department of Urology, The First Dongguan Affiliated Hospital, Guangdong Medical University, Dongguan, Guangdo
Externí odkaz:
https://doaj.org/article/199f287bbbdc49bcba9b76970c57ad8b
Autor:
Ping Cheng, Botao Wang, Shuying Liang, Yuqi Yang, Shixin Gui, Kai Zhang, Yingying Sun, Shaoqi Qu, Lin Li
Publikováno v:
Arabian Journal of Chemistry, Vol 17, Iss 10, Pp 105988- (2024)
Colistin used to be regarded as the last-resort treatment for the infection caused by multidrug-resistant gram-negative bacteria. However, the emergence and widespread of mcr-1 seriously reduce the clinical effectiveness of colistin, constituting a s
Externí odkaz:
https://doaj.org/article/20c4f74078f049d59d97261082c62ccb
Publikováno v:
Frontiers in Microbiology, Vol 15 (2024)
IntroductionDeveloping antibiotic adjuvants is an effective strategy to combat antimicrobial resistance (AMR). The envelope of Gram-negative bacteria (GNB) is a barrier to prevent the entry of antibiotics, making it an attractive target for novel ant
Externí odkaz:
https://doaj.org/article/3a92cce3c73f4bf2b93197aa53e59688
Autor:
Xuejia Jiang, Dongliang Chen, Xiaoyang Wang, Chunmei Wang, Haihong Zheng, Wenchong Ye, Wen Zhou, Guoping Liu, Keyu Zhang
Publikováno v:
Microbiology Spectrum, Vol 12, Iss 8 (2024)
ABSTRACT The rapid expansion of antibiotic-resistant bacterial diseases is a global burden on public health. It makes sense to repurpose and reposition already-approved medications for use as supplementary agents in synergistic combinations with exis
Externí odkaz:
https://doaj.org/article/d5f6ceb6df54404c8d57e74906365089
Autor:
Apurva Panjla, Grace Kaul, Manjulika Shukla, Abdul Akhir, Sarita Tripathi, Ashish Arora, Sidharth Chopra, Sandeep Verma
Publikováno v:
Biomedicine & Pharmacotherapy, Vol 176, Iss , Pp 116810- (2024)
Globally, infections due to multi-drug resistant (MDR) Gram-negative bacterial (GNB) pathogens are on the rise, negatively impacting morbidity and mortality, necessitating urgent treatment alternatives. Herein, we report a detailed bio-evaluation of
Externí odkaz:
https://doaj.org/article/7a065d99dbf34af1903a7a30b2c7eaf3
Autor:
Huangwei Song, Xueyang Wang, Muchen Zhang, Zhiyu Zou, Siyuan Yang, Tian Yi, Jianfeng Wang, Dejun Liu, Yingbo Shen, Chongshan Dai, Zhihai Liu, Timothy R. Walsh, Jianzhong Shen, Congming Wu, Yang Wang
Publikováno v:
Engineering, Vol 32, Iss , Pp 163-173 (2024)
The emergence and spread of the mobile colistin-resistance gene, mcr-1, and its variants pose a challenge to the use of colistin, a last-resort antibiotic used to treat severe infections caused by extensively drug-resistant (XDR) Gram-negative pathog
Externí odkaz:
https://doaj.org/article/fdaad9a2f0f84a748f42b929b5a77592
Autor:
Xiaoou Zhao, Mengna Zhang, Zhendu Zhang, Lei Wang, Yu Wang, Lizai Liu, Duojia Wang, Xin Zhang, Luobing Zhao, Yunhui Zhao, Xiangshu Jin, Xiaoxiao Liu, Hongxia Ma
Publikováno v:
Antibiotics, Vol 13, Iss 10, p 973 (2024)
The worrying issue of antibiotic resistance in pathogenic bacteria is aggravated by the scarcity of novel therapeutic agents. Antibiotic adjuvants offer a promising solution due to their cost-effectiveness and high efficacy in addressing this issue,
Externí odkaz:
https://doaj.org/article/79e231495a264146afe504da8f6ffcae
Publikováno v:
Advanced Science, Vol 11, Iss 17, Pp n/a-n/a (2024)
Abstract Hematoma, a risk factor of implant‐associated infections (IAIs), creates a Fe‐rich environment following implantation, which proliferates the growth of pathogenic bacteria. Fe metabolism is a major vulnerability for pathogens and is cruc
Externí odkaz:
https://doaj.org/article/ae67e3e6cb5243e295f2999799de0cbd
Publikováno v:
Infection and Drug Resistance, Vol Volume 16, Pp 7313-7326 (2023)
Hongjuan Zhou, Wenli Wang, Long Cai, Tingting Yang Clinical Laboratory Experiment Center, Affiliated Hangzhou Chest Hospital, Zhejiang University School of Medicine, Hangzhou, Zhejiang, People’s Republic of ChinaCorrespondence: Tingting Yang; Long
Externí odkaz:
https://doaj.org/article/4775b4652de84ad18e158942b7b1b081
Publikováno v:
International Journal of Molecular Sciences, Vol 25, Iss 13, p 7069 (2024)
Combining commercial antibiotics with adjuvants to lower their minimum inhibitory concentration (MIC) is vital in combating antimicrobial resistance. Evaluating the ecotoxicity of such compounds is crucial due to environmental and health risks. Here,
Externí odkaz:
https://doaj.org/article/5afa37e75d8247f78e686c0e0dd73e08