Discovery of a fragment hit compound targeting D-Ala

Autor: Proj, Matic, Hrast, Martina, Bajc, Gregor, dipl biol, Frlan, Rok, Meden, Anže, Butala, Matej, biokemik, Gobec, Stanislav

Publikováno v: Journal of enzyme inhibition and medicinal chemistry, vol. 38, no. 11, pp. 387-397, 2023.
Journal of enzyme inhibition and medicinal chemistry, str. 387-397 : Ilustr., Vol. 38, iss. 1, 2023
COBISS-ID: 22763225

Bacterial resistance is an increasing threat to healthcare systems, highlighting the need for discovering new antibacterial agents. An established technique, fragment-based drug discovery, was used to target a bacterial enzyme Ddl involved in the bio

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=dedup_wf_001::785471e52d8f9c46a5a6594fdb08ec69
https://repozitorij.uni-lj.si/Dokument.php?id=164549&dn=

Covalent inhibitors of bacterial peptidoglycan biosynthesis enzyme MurA with chloroacetamide warhead

Autor: Katarina Grabrijan, Martina Hrast, Matic Proj, Ana Dolšak, Irena Zdovc, Tímea Imre, László Petri, Péter Ábrányi-Balogh, György M. Keserű, Stanislav Gobec

Publikováno v: European journal of medicinal chemistry, vol. 243, 114752, 2022.
European journal of medicinal chemistry, 15 str. : Ilustr., Vol. 243, 2022
COBISS-ID: 25429760

MurA (UDP-N-acetylglucosamine enolpyruvyl transferase) catalyzes the first committed step in the cytoplasmic part of peptidoglycan biosynthesis and is a validated target enzyme for antibacterial drug discovery; the inhibitor fosfomycin has been used

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f34758dec7221e92b09df5bda2613d3f
https://doi.org/10.1016/j.ejmech.2022.114752

Utjecaj COVID-19 pandemije na potrošnju lijekova u dentalnoj medicini u Republici Hrvatskoj

Autor: Plazonić, Iva

Novi koronavirus pojavio se u Kini krajem 2019. godine, a nazvan je SARS-CoV-2 (Severe Acute Respiratory Syndrome Coronavirus-2). Radi se o novom soju koronavirusa koji prije nije bio zabilježen kod ljudi. Bolest uzrokovana ovim virusom naziva se CO

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=od______3699::2321af80d0fbcf1018279f4fe45c8bf8
https://repozitorij.sfzg.unizg.hr/islandora/object/sfzg:1133

DNA-encoded library screening on two validated enzymes of the peptidoglycan biosynthetic pathway

Autor: Matic Proj, Krištof Bozovičar, Martina Hrast, Rok Frlan, Stanislav Gobec

Publikováno v: Bioorganic & medicinal chemistry letters, vol. 73, no. 128915, 2022.
Bioorganic & Medicinal Chemistry Letters, 4 str. : Ilustr., Vol. 73, art. 128915, 2022
COBISS-ID: 34486272

Screening of DNA-encoded libraries is an emerging technology for discovering hits against protein targets. With the recent launch of the DELopen platform, a facile screening of 4.4 billion compounds is available to accelerate the drug discovery proce

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::17915ac93d1a3e63a6b81b81578b374c
https://doi.org/10.1016/j.bmcl.2022.128915

Znanje i stajališta doktora dentalne medicine u Hrvatskoj o propisivanju antibiotika u endodonciji: presječno istraživanje

Autor: Šimundić Munitić, Marija, Šutej, Ivana, Ćaćić, Nensi, Tadin, Antonija, Balić, Merima, Bago, Ivona, Poklepović Peričić, Tina

Objectives: To assess dentists’ level of knowledge and practice concerning antibiotic usage in endodontics using the European Society of Endodontology position statement as a reference. Material and Methods: A cross-sectional study was conducted in

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=57a035e5b1ae::70fa32186a3e43a26ad8e4003266c281
https://www.bib.irb.hr/1167565