Zobrazeno 1 - 10
of 2 209
pro vyhledávání: '"anti-tumor immunity"'
Autor:
Liam F. Spurr, Sean P. Pitroda
Publikováno v:
Scientific Reports, Vol 14, Iss 1, Pp 1-10 (2024)
Abstract Recent studies have linked elevated tumor aneuploidy to anti-tumor immune suppression and adverse survival following immunotherapy. Herein, we provide supportive evidence for tumor aneuploidy as a biomarker of response to immunotherapy in pa
Externí odkaz:
https://doaj.org/article/27afba756f854d3d8ae09d61094408de
Publikováno v:
Cell Communication and Signaling, Vol 22, Iss 1, Pp 1-16 (2024)
Abstract Background In triple-negative breast cancer (TNBC) therapy, insufficient tumor infiltration by lymphocytes significantly hinders the efficacy of immune checkpoint inhibitors. We have previously demonstrated that Hainanenin-1 (HN-1), a host d
Externí odkaz:
https://doaj.org/article/4e8922e57b7c443bbe67f7c718280b7a
Publikováno v:
Journal of Nanobiotechnology, Vol 22, Iss 1, Pp 1-21 (2024)
Abstract Chemotherapy and immunotherapy have shown no significant outcome for unresectable pancreatic ductal adenocarcinoma (PDAC). Multi-drug combination therapy has become a consensus in clinical trials to explore how to arouse anti-tumor immunity
Externí odkaz:
https://doaj.org/article/636570c8b9454344bfa1c84aa7444ff6
Publikováno v:
Journal of Translational Medicine, Vol 22, Iss 1, Pp 1-20 (2024)
Abstract Background Telomerase, by safeguarding damaged telomeres and bolstering DNA damage repair, has the capacity to heighten the radioresistance of tumour cells. Thus, in turn, can compromise the efficacy of radiotherapy (RT) and radioimmunothera
Externí odkaz:
https://doaj.org/article/56775fe79e2c4b5487b985d449e20b9f
Publikováno v:
Discover Oncology, Vol 15, Iss 1, Pp 1-17 (2024)
Abstract Interleukin-12 (IL-12) can be used as an immunomodulator in cancer immunotherapy. And it has demonstrated enormous potential in inhibiting tumor growth and improving the tumor microenvironment (TME) by several preclinical models. However, so
Externí odkaz:
https://doaj.org/article/e085a92bf1b14525b5e043b99a1587b8
Publikováno v:
Journal of Experimental & Clinical Cancer Research, Vol 43, Iss 1, Pp 1-28 (2024)
Abstract High-throughput sequencing has ushered in a paradigm shift in gastric microbiota, breaking the stereotype that the stomach is hostile to microorganisms beyond H. pylori. Recent attention directed toward the composition and functionality of t
Externí odkaz:
https://doaj.org/article/02a820f011f4464bb9983424825ed9a3
Publikováno v:
Frontiers in Immunology, Vol 15 (2024)
The human microbiome has recently emerged as a focal point in cancer research, specifically in anti-tumor immunity, immunotherapy, and chemotherapy. This review explores microbial-derived metabolites, emphasizing their crucial roles in shaping fundam
Externí odkaz:
https://doaj.org/article/800efd59fd10408e9c4c99aaa94c085b
Publikováno v:
EBioMedicine, Vol 107, Iss , Pp 105301- (2024)
Summary: Increasing evidence indicates that immunotherapy is hindered by a hostile tumor microenvironment (TME) featured with deprivation of critical nutrients and pooling of immunosuppressive metabolites. Tumor cells and immunosuppressive cells outc
Externí odkaz:
https://doaj.org/article/25728ac5d7934f578eb4f4241f37efc2
Autor:
Yingying Lyu, Chaxian Liu, Hao Lin, Haikun Song, Qiyuan Zhuang, Ankang Hu, Liang Chen, Hui Yang, Ying Mao
Publikováno v:
Heliyon, Vol 10, Iss 17, Pp e36415- (2024)
Targeting nucleotide enzymes emerges as a promising avenue for impeding tumor proliferation and fortifying anti-tumor immunogenicity. The non-canonical role of nucleotide enzymes remains poorly understood. In this study, we have identified that Phosp
Externí odkaz:
https://doaj.org/article/f6b6293c0dcf487eb2fbed889b89a12a