Zobrazeno 1 - 10
of 127
pro vyhledávání: '"anti-cancer drug resistance"'
Publikováno v:
Current Issues in Molecular Biology, Vol 46, Iss 6, Pp 5178-5193 (2024)
Histone deacetylase 9 (HDAC9) is known to be upregulated in various cancers. Cancer-associated antigens (CAGEs) are cancer/testis antigens that play an important role in anti-cancer drug resistance. This study aimed to investigate the relationship be
Externí odkaz:
https://doaj.org/article/9dd815432e864cd188e5daf6888066f8
Autor:
Heewon Park, Satoru Miyano
Publikováno v:
International Journal of Molecular Sciences, Vol 25, Iss 6, p 3302 (2024)
Azacitidine, a DNA methylation inhibitor, is employed for the treatment of acute myeloid leukemia (AML). However, drug resistance remains a major challenge for effective azacitidine chemotherapy, though several studies have attempted to uncover the m
Externí odkaz:
https://doaj.org/article/88282f61a8844d428c163aecdd678aee
Publikováno v:
Computational and Structural Biotechnology Journal, Vol 21, Iss , Pp 2048-2057 (2023)
Histone deacetylases (HDACs) deacetylate histones H3 and H4. An imbalance between histone acetylation and deacetylation can lead to various diseases. HDAC2 is present in the nucleus. It plays a critical role in modifying chromatin structures and regu
Externí odkaz:
https://doaj.org/article/551820f2c00546379744679faa0ec60f
Akademický článek
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Publikováno v:
Computational and Structural Biotechnology Journal, Vol 19, Iss , Pp 2384-2397 (2021)
Breast cancer (BC) is the most common type of cancer in women at the global level and the highest mortality rate has been observed with triple-negative breast cancer (TNBC). Accumulation of genetic lesions an aberrant gene expression and protein degr
Externí odkaz:
https://doaj.org/article/178ce172ec274e2197e73b65df02051c
Publikováno v:
Frontiers in Oncology, Vol 12 (2022)
Breast cancer is one of the leading threats to the health of women. It has the highest incidence and mortality in women worldwide. Although progress has been made in the development and application of anti-breast cancer drugs such as Chidamide and ot
Externí odkaz:
https://doaj.org/article/0328fcc48ac14a21948787ab3ff12d30
Akademický článek
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Publikováno v:
International Journal of Molecular Sciences, Vol 23, Iss 17, p 9592 (2022)
Histone deacetylases (HDACs) regulate gene expression through the epigenetic modification of chromatin structure. HDAC6, unlike many other HDACs, is present in the cytoplasm. Its deacetylates non-histone proteins and plays diverse roles in cancer cel
Externí odkaz:
https://doaj.org/article/3088f086ace145bf9f61c693f941a451
Publikováno v:
International Journal of Molecular Sciences, Vol 23, Iss 11, p 5881 (2022)
MicroRNAs (miRNAs) are small non-coding RNAs (18–24 nucleotides) that play significant roles in cell proliferation, development, invasion, cancer development, cancer progression, and anti-cancer drug resistance. miRNAs target multiple genes and pla
Externí odkaz:
https://doaj.org/article/fe808726e3284c948c590330cc58f825
Publikováno v:
Frontiers in Cell and Developmental Biology, Vol 8 (2020)
Therapies that target oncogenes and immune checkpoint molecules constitute a major group of treatments for metastatic melanoma. A mutation in BRAF (BRAF V600E) affects various signaling pathways, including mitogen activated protein kinase (MAPK) and
Externí odkaz:
https://doaj.org/article/d7e8f5675ab04c3ab1678aba83ace04c