Zobrazeno 1 - 10
of 2 493
pro vyhledávání: '"anti-cancer activity"'
Autor:
Manar G. Salem, Mohamed S. Nafie, Aya A. Elzamek, Hosam A. Elshihawy, Mamdouh A. Sofan, Elham Negm
Publikováno v:
BMC Chemistry, Vol 18, Iss 1, Pp 1-14 (2024)
Abstract New Series of N-Manniche bases 3,4 (a-c) and 5,6 (a-b) were synthesized through the reaction of benzaldehyde and amine with 3-methyl-4-(aryldiazenyl)-1H-pyrazol-5-ol derivatives 2(a-c), they were fully characterized by FT-IR, (1H, 13C) NMR d
Externí odkaz:
https://doaj.org/article/7474fc85527a42a39396aa6ae9f4d4a6
Publikováno v:
BMC Molecular and Cell Biology, Vol 25, Iss 1, Pp 1-14 (2024)
Abstract Background Bacillus strains are well recognized for their inherent production of bioactive compounds that exhibit antibacterial and anticancer properties. This study aims to evaluate the antimicrobial and anticancer effects of the secondary
Externí odkaz:
https://doaj.org/article/8d830323f8d54097b756e8eb9d504b8e
Publikováno v:
Journal of Pharmacy and Bioallied Sciences, Vol 16, Iss 6, Pp 1270-1273 (2024)
Sesuvium portulacastrum, a coastal medicinal plant with traditional uses has shown promising biological activities including anti-inflammatory, antioxidant and antimicrobial properties. However, the mechanisms of action active ingredients of this pla
Externí odkaz:
https://doaj.org/article/d294e80297aa4c398606a1f0fc6475f6
Publikováno v:
Future Journal of Pharmaceutical Sciences, Vol 10, Iss 1, Pp 1-15 (2024)
Abstract Background Researchers, prompted by the toxicity and side effects associated with cisplatin, are exploring alternative approaches for developing transition metal-based anticancer agents. Employing a green biochemical approach, we transformed
Externí odkaz:
https://doaj.org/article/57fc5bdf8e1f490a90f540e9ece861bf
Publikováno v:
Heliyon, Vol 10, Iss 16, Pp e35897- (2024)
Forty-one derivatives of spirooxindoles, active against HCT-116 colon cancer cells, underwent pharmacophore-based 3D-QSAR analysis to understand their correlation with anti-cancer activity. The study identified a seven-point pharmacophore model (ADHH
Externí odkaz:
https://doaj.org/article/82b755ddc7e94a85867efaaf870ed879
Autor:
Shamaila Yousaf, Komal Shahzadi
Publikováno v:
Frontiers in Chemistry, Vol 12 (2024)
The exploration of non-cancer medications with potential anti-cancer activity offers a promising avenue for drug repurposing, accelerating the development of new oncological therapies. This study employs Quantitative Structure-Property Relationship (
Externí odkaz:
https://doaj.org/article/263cee836cca44d587f6b31db1f4c2f5
Autor:
Fares Hezam Al-Ostoot, P. Akhileshwari, Vivek Hamse Kameshwar, D.V. Geetha, Majed S. Aljohani, Hussam Y. Alharbi, Shaukath Ara Khanum, M.A. Sridhar
Publikováno v:
Heliyon, Vol 10, Iss 13, Pp e33814- (2024)
This study explores the pharmacological potential of chalcones through a multidisciplinary approach, including synthesis, quantum theory, molecular electrostatics, and density functional theory (DFT) calculations. The synthesized compound, analyzed v
Externí odkaz:
https://doaj.org/article/7e9ca44b07db42b7bc11970455d8b4bc
Autor:
Juan S. Alarcón-Aldana, Lydia Visser, Nohora J. Rueda-Forero, Efraín H. Pinzón-Reyes, Paola Rondón-Villarreal, Miguel O. Suárez-Barrera
Publikováno v:
Toxins, Vol 16, Iss 10, p 415 (2024)
Parasporin PS2Aa1, recently renamed Mpp46Aa1, is an anti-cancer protein known for its selectivity against various human cancer cell lines. We genetically modified native PS2Aa1 to create a library of approximately 100 mutants. From this library, we s
Externí odkaz:
https://doaj.org/article/7e05bea37a0547889b30b7c2ecc8855d
Publikováno v:
Molecules, Vol 29, Iss 19, p 4653 (2024)
Drawing inspiration from the structural resemblance between a natural product N-(3-carboxypropyl)-2-acetylpyrrole and phenylbutyric acid, a pioneer HDAC inhibitor evaluated in clinical trials, we embarked on the design and synthesis of a novel array
Externí odkaz:
https://doaj.org/article/fe8ac4bb0bae42649611333190cfcf11
Publikováno v:
Drug Design, Development and Therapy, Vol Volume 17, Pp 2909-2929 (2023)
Zhichao Xing,1,* Anping Su,1,* Li Mi,1 Yujie Zhang,1 Ting He,1 Yuxuan Qiu,2 Tao Wei,1 Zhihui Li,1 Jingqiang Zhu,1 Wenshuang Wu1 1Division of Thyroid Surgery, Department of General Surgery and Laboratory of Thyroid and Parathyroid Disease, Fro
Externí odkaz:
https://doaj.org/article/4eeff0955c07408c85138e4b22bf4db4