Zobrazeno 1 - 10
of 16
pro vyhledávání: '"anna Konturek"'
Publikováno v:
eLife, Vol 12 (2024)
The scarcity of hematopoietic stem cells (HSCs) restricts their use in both clinical settings and experimental research. Here, we examined a recently developed method for expanding rigorously purified murine HSCs ex vivo. After 3 weeks of culture, on
Externí odkaz:
https://doaj.org/article/3905155e244846d08981cb4fe022f738
Autor:
Anna Konturek-Ciesla, Parashar Dhapola, Qinyu Zhang, Petter Säwén, Haixia Wan, Göran Karlsson, David Bryder
Publikováno v:
Cell Reports, Vol 42, Iss 4, Pp 112304- (2023)
Summary: Aging negatively affects hematopoiesis, with consequences for immunity and acquired blood cell disorders. Although impairments in hematopoietic stem cell (HSC) function contribute to this, the in vivo dynamics of such changes remain obscure.
Externí odkaz:
https://doaj.org/article/16e2103f62f84a6d9818638bcd2db14c
Autor:
Mohamed Eldeeb, Ouyang Yuan, Nicola Guzzi, Phuong Cao Thi Ngoc, Anna Konturek-Ciesla, Trine A. Kristiansen, Sowndarya Muthukumar, Jeffrey Magee, Cristian Bellodi, Joan Yuan, David Bryder
Publikováno v:
Cell Reports, Vol 42, Iss 2, Pp 112099- (2023)
Summary: MLL-rearrangements (MLL-r) are recurrent genetic events in acute myeloid leukemia (AML) and frequently associate with poor prognosis. In infants, MLL-r can be sufficient to drive transformation. However, despite the prenatal origin of MLL-r
Externí odkaz:
https://doaj.org/article/11caa6fa37dc4e3b9665a0f94329e489
Autor:
Anna Konturek-Ciesla, David Bryder
Publikováno v:
Frontiers in Cell and Developmental Biology, Vol 10 (2022)
An appropriate production of mature blood cells, or hematopoiesis, is essential for organismal health and homeostasis. In this developmental cascade, hematopoietic stem cells (HSCs) differentiate into intermediate progenitor types, that subsequently
Externí odkaz:
https://doaj.org/article/3ad3e0695bc14407b9e27d010b1a638b
Hematopoietic stem cells (HSCs) reside at the apex of hematopoiesis, can maintain this function for life, and are the functional units in clinical bone marrow transplantation. Limitations in HSC numbers not only restricts their clinical use but also
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::f415ce68fae0e53d041e13e97bc215cb
https://doi.org/10.1101/2022.06.20.496822
https://doi.org/10.1101/2022.06.20.496822
Autor:
Ouyang, Yuan, Amol, Ugale, Tommaso, de Marchi, Vimala, Anthonydhason, Anna, Konturek-Ciesla, Haixia, Wan, Mohamed, Eldeeb, Caroline, Drabe, Maria, Jassinskaja, Jenny, Hansson, Isabel, Hidalgo, Talia, Velasco-Hernandez, Jörg, Cammenga, Jeffrey A, Magee, Emma, Niméus, David, Bryder
Publikováno v:
Science advances. 8(16)
Acute myeloid leukemia (AML) arises when leukemia-initiating cells, defined by a primary genetic lesion, acquire subsequent molecular changes whose cumulative effects bypass tumor suppression. The changes that underlie AML pathogenesis not only provi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::66fd0fb53c08f7631a0e5076964cafc8
https://pubmed.ncbi.nlm.nih.gov/35442741
https://pubmed.ncbi.nlm.nih.gov/35442741
Autor:
Aleksandra Wieczorek, Maciej Cieśla, Witold Nowak, Monika Gońka, Anna Konturek-Cieśla, Katarzyna Pawińska-Wąsikowska, Ewelina Pitera, Alicja Jozkowicz, Karolina Bukowska-Strakova, Magdalena Kozakowska, Joanna Włodek, Maciej Siedlar
Publikováno v:
International Journal of Molecular Sciences
Volume 22
Issue 3
International Journal of Molecular Sciences, Vol 22, Iss 988, p 988 (2021)
Volume 22
Issue 3
International Journal of Molecular Sciences, Vol 22, Iss 988, p 988 (2021)
Whilst the survival rates of childhood acute lymphoblastic leukemia (ALL) have increased remarkably over the last decades, the therapy resistance and toxicity are still the major causes of treatment failure. It was shown that overexpression of heme o
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::493c03469fc26a61dcced14154fa12b2
Autor:
Karolina, Bukowska-Strakova, Joanna, Włodek, Ewelina, Pitera, Magdalena, Kozakowska, Anna, Konturek-Cieśla, Maciej, Cieśla, Monika, Gońka, Witold, Nowak, Aleksandra, Wieczorek, Katarzyna, Pawińska-Wąsikowska, Alicja, Józkowicz, Maciej, Siedlar
Publikováno v:
International Journal of Molecular Sciences
Whilst the survival rates of childhood acute lymphoblastic leukemia (ALL) have increased remarkably over the last decades, the therapy resistance and toxicity are still the major causes of treatment failure. It was shown that overexpression of heme o
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::9534a6b77054c02cbb54414263571cb8
https://pubmed.ncbi.nlm.nih.gov/33498175
https://pubmed.ncbi.nlm.nih.gov/33498175
Autor:
Anna Konturek-Ciesla, Parashar Dhapola, Qinyu Zhang, Petter Säwen, Haixia Wan, Göran Karlsson, David Bryder
Publikováno v:
Experimental Hematology. 111:S47
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::7b1faa6273600a1e05281c5e46d4df4b
https://doi.org/10.1016/j.exphem.2022.07.061
https://doi.org/10.1016/j.exphem.2022.07.061
Autor:
Krzysztof Szade, Maciej Siedlar, Maciej Ciesla, Anna Konturek, Robert Straka, Karolina Bukowska-Strakova, Karolina Najder, Małgorzata Tyszka-Czochara, Alicja Jozkowicz, Witold Nowak, Agata Szade, Jozef Dulak
Publikováno v:
Immunobiology. 222:846-857
Heme oxygenase-1 (HO-1) is stress-inducible, cytoprotective enzyme degrading heme to carbon monoxide (CO), biliverdin and Fe2+. We showed that HO-1 knock-out mice (HO-1-/-) have a twofold higher level of granulocytes than wild type (WT) mice, despite
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::148baf92d965f930027292559d2db1df
https://doi.org/10.1016/j.imbio.2017.05.006
https://doi.org/10.1016/j.imbio.2017.05.006