Direct angiotensin type 2 receptor (AT 2R) stimulation attenuates T-cell and microglia activation and prevents demyelination in experimental autoimmune encephalomyelitis in mice

Autor: Björn Dahlöf, Florianne Monnet-Tschudi, Veronica Valero-Esquitino, Daniel C. Villela, Anders Hallberg, Ludovit Paulis, U. Muscha Steckelings, Thomas Unger, Pawel Namsolleck, Meng Liu, Franziska Lucht, Tobias Stubbe, Christa Thoene-Reineke, Christine Brandt, Kristin Lucht, Colin Sumners, Friederike Ebner, Leon Alexander Danyel

Publikováno v: Valero-Esquitino, V, Lucht, K, Namsolleck, P, Monnet-Tschudi, F, Stubbe, T, Lucht, F, Liu, M, Ebner, F, Brandt, C, Danyel, L A, Villela, D C, Paulis, L, Thoene-Reineke, C, Dahlöf, B, Hallberg, A, Unger, T, Sumners, C & Steckelings, U M 2015, ' Direct angiotensin type 2 receptor (AT 2 R) stimulation attenuates T-cell and microglia activation and prevents demyelination in experimental autoimmune encephalomyelitis in mice ', Clinical Science, vol. 128, no. 2, pp. 95–109 . https://doi.org/10.1042/CS20130601
Clinical Science, 128(2), 95-109. Portland Press Ltd.

In the present study, we evaluated stimulation of the angiotensin type 2 receptor (AT2R) by the selective non-peptide agonist Compound 21 (C21) as a novel therapeutic concept for the treatment of multiple sclerosis using the model of experimental aut

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https://portal.findresearcher.sdu.dk/da/publications/906bc3b1-5591-45bc-a2eb-c76eada71aab

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