ST-2191, an Anellated Bismorpholino Derivative of Oxy-Fingolimod, Shows Selective S1P1 Agonist and Functional Antagonist Potency In Vitro and In Vivo

Autor: Thomas Homann, Aleksandra Zivkovic, Andrea Huwiler, Bisera Stepanovska Tanturovska, Faik Imeri, Holger Stark, Burkhard Kleuser

Publikováno v: Molecules
Volume 26
Issue 17
Stepanovska Tanturovska, Bisera; Zivkovic, Aleksandra; Imeri, Faik; Homann, Thomas; Kleuser, Burkhard; Stark, Holger; Huwiler, Andrea (2021). ST-2191, an Anellated Bismorpholino Derivative of Oxy-Fingolimod, Shows Selective S1P1 Agonist and Functional Antagonist Potency In Vitro and In Vivo. Molecules, 26(17) Molecular Diversity Preservation International MDPI 10.3390/molecules26175134
Molecules, Vol 26, Iss 5134, p 5134 (2021)

Sphingosine 1-phosphate (S1P) is an extensively studied signaling molecule that contributes to cell proliferation, survival, migration and other functions through binding to specific S1P receptors. The cycle of S1P1 internalization upon S1P binding a

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