Zobrazeno 1 - 10
of 84
pro vyhledávání: '"androgen receptor signaling pathway"'
Publikováno v:
Heliyon, Vol 8, Iss 12, Pp e12114- (2022)
Objectives: Androgen deprivation therapy (ADT) is a standard treatment for advanced prostate cancer (PCa). However, after 2–3 years ADT treatment, prostate cancer inevitably transits from androgen-dependent PCa (ADPC) to androgen-independent PCa (A
Externí odkaz:
https://doaj.org/article/c1d6196bb4764b4abf98e03454312ec4
Akademický článek
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Autor:
Pengju Guo, Yongguang Jiang, Mingchuan Li, Jiahui Zhao, Qiankun Li, Dechao Wei, Yong Luo, Tao Feng, Xiaobing Yang
Publikováno v:
Exp Biol Med (Maywood)
Among many factors of causing castration-resistant prostate cancer (CRPC) progression, a growing number of evidences have shown androgen receptors play a critical role. Therefore, blocking androgen receptor remains a therapeutic goal of CRPC. However
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6502bdd0ef9b9f15a0b64492b60fdf87
https://doi.org/10.1177/15353702211012625
https://doi.org/10.1177/15353702211012625
Publikováno v:
Advances in Clinical and Experimental Medicine. 29:1153-1160
Background The post-translational modifications of proteins control various physiological and pathological events in cells. Objectives In this study, we investigated the influences of the X-linked deubiquitination enzyme USP26 in mediating androgen r
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::398369f81af02deb4bcb943fa0c625c6
https://doi.org/10.17219/acem/123355
https://doi.org/10.17219/acem/123355
Autor:
Huijuan Song, Manlin Wang, Chunyu Wang, Chi Lv, Shengli Wang, Wei Liu, Wensu Liu, Xinping Zhong, Lin Lin, Kai Zeng, Shan Wei, Yue Zhao, Baosheng Zhou, Ning Sun
Publikováno v:
Cancer Science
Androgen receptor (AR) signaling is considered to be crucial for the pathogenesis of hepatocellular carcinoma (HCC) with obvious sexual dimorphism. Pre‐mRNA processing factor 6 (PRPF6) was identified as a coactivator of AR. However, the molecular m
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::472f4d78701891d408bf76c6a8816c73
https://doi.org/10.1111/cas.14595
https://doi.org/10.1111/cas.14595
Akademický článek
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Publikováno v:
Oncology Letters
The present study aimed to establish a mouse model of patient-derived castration-resistant prostate cancer (CRPC) xenograft tumors, and to evaluate the effects of various doses of metformin on phospholipase Ce (PLCe) expression and the neurogenic loc
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f9431df3b3d0e6cc0449d3c70e96285d
https://pubmed.ncbi.nlm.nih.gov/34429755
https://pubmed.ncbi.nlm.nih.gov/34429755
Autor:
Haiping Ma, Tingting Cai, Jianping Xiu, Xin Kang, Tie Zhou, Li Zhang, Song Li, Shouyan Tang, Weidong Xu, Naping Zhao, Shen Gao, Jin Ni
Publikováno v:
The Prostate. 82(2)
BACKGROUND Preclinical studies showed that HC-1119, a deuterated version of enzalutamide, could competitively inhibit androgen binding to androgen receptor by blocking the transmission of androgen receptor signaling pathway as enzalutamide, inducing
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::26b2dede6886c4ade8a13914dae4a3df
https://pubmed.ncbi.nlm.nih.gov/34807458
https://pubmed.ncbi.nlm.nih.gov/34807458
Autor:
Yong Wu, Yong Peng, Guoxian Guan, Weizhong Jiang, Yiyi Zhang, Xing Liu, Yuanfeng Yang, Jinfu Zhuang, Qiao Gao
Publikováno v:
Frontiers in Cell and Developmental Biology
Frontiers in Cell and Developmental Biology, Vol 9 (2021)
Frontiers in Cell and Developmental Biology, Vol 9 (2021)
BackgroundTo identify the hub genes associated with chemoradiotherapy resistance in rectal cancer and explore the potential mechanism.MethodsWeighted gene co-expression network analysis (WGCNA) was performed to identify the gene modules correlated wi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a555d5848624901b7fbbcbc161ca5d66
https://doi.org/10.3389/fcell.2021.607782
https://doi.org/10.3389/fcell.2021.607782
Autor:
Shuzhen Zhu, Yida Hu, Qing Wang, Yun Li, Wei Wang, Min Yang, Fangshuo Zheng, Xiaobo Wei, Yuanlin Ma, Demei Xu, Yangfu Luo, Miaoqing He, Yi Yang, Xiaoya Gao, Junhong Ma, Hui Liu, Qin Yang, Xuefeng Wang, Zifeng Huang
Publikováno v:
EBioMedicine
Background NACHT and WD repeat domain-containing protein 1 (Nwd1) is a member of the innate immune protein subfamily. Nwd1 contributes to the androgen receptor signaling pathway and is involved in axonal growth. However, the mechanisms that underlie
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a49ac86b31094257f371754aef460ee8
http://europepmc.org/articles/PMC6796588
http://europepmc.org/articles/PMC6796588