Zobrazeno 1 - 10
of 924
pro vyhledávání: '"androgen receptor (AR)"'
Publikováno v:
Neoplasia: An International Journal for Oncology Research, Vol 57, Iss , Pp 101045- (2024)
PSMA expression gradually increases from benign prostatic hyperplasia to adenocarcinoma of the prostate and is therefore used for the development of improved diagnostic (PSMA)‐based prostate cancer imaging tools. Pharmacological induction of PSMA i
Externí odkaz:
https://doaj.org/article/8478a7f4e35142058873a3693c25cd98
Publikováno v:
Environment International, Vol 191, Iss , Pp 108995- (2024)
Traditional methods for identifying endocrine-disrupting chemicals (EDCs) that activate androgen receptors (AR) are costly, time-consuming, and low-throughput. This study developed a knowledge-based deep neural network model (AR-DNN) to predict AR-me
Externí odkaz:
https://doaj.org/article/510c760ce9fb46bb95c5b2fc07f9add8
Autor:
CAI Renjie, XU Ming
Publikováno v:
Shanghai Jiaotong Daxue xuebao. Yixue ban, Vol 44, Iss 4, Pp 417-426 (2024)
Objective·To investigate the impact of KH-type splicing regulatory protein (KHSRP) on the proliferation of prostate cancer cells and the regulation of downstream gene expression, and explore the potential role and mechanism of KHSRP in the transitio
Externí odkaz:
https://doaj.org/article/064848b6028249afbca461cbc0128f6e
Publikováno v:
Pharmacological Research, Vol 205, Iss , Pp 107234- (2024)
After the initial androgen deprivation therapy (ADT), part of the prostate cancer may continuously deteriorate into castration-resistant prostate cancer (CRPC). The majority of patients suffer from the localized illness at primary diagnosis that coul
Externí odkaz:
https://doaj.org/article/364ce6bf959a46618f61dcba2c1d960b
Autor:
Chi-Ming Liu, ZiChen Shao, XuZhou Chen, HanWu Chen, MengQiao Su, ZiWen Zhang, ZhengPing Wu, Peng Zhang, LiJie An, YinJie Jiang, Ai-Jun Ouyang
Publikováno v:
Saudi Pharmaceutical Journal, Vol 31, Iss 7, Pp 1219-1228 (2023)
Benign prostatic hyperplasia (BPH) is a common urinary disease among the elderly, characterized by abnormal prostatic cell proliferation. Neferine is a dibenzyl isoquinoline alkaloid extracted from Nelumbo nucifera and has antioxidant, anti-inflammat
Externí odkaz:
https://doaj.org/article/d6a77d813781480d844af31e551010b8
Autor:
Daniel J. Turnham, Manisha S. Mullen, Nicholas P. Bullock, Kathryn L. Gilroy, Anna E. Richards, Radhika Patel, Marcos Quintela, Valerie S. Meniel, Gillian Seaton, Howard Kynaston, Richard W. E. Clarkson, Toby J. Phesse, Peter S. Nelson, Michael C. Haffner, John N. Staffurth, Helen B. Pearson
Publikováno v:
Cells, Vol 13, Iss 8, p 673 (2024)
As the treatment landscape for prostate cancer gradually evolves, the frequency of treatment-induced neuroendocrine prostate cancer (NEPC) and double-negative prostate cancer (DNPC) that is deficient for androgen receptor (AR) and neuroendocrine (NE)
Externí odkaz:
https://doaj.org/article/1e39ec5e9d2d4ad899c5d22bfe802b4a
Publikováno v:
International Journal of Molecular Sciences, Vol 25, Iss 1, p 101 (2023)
C11-oxy C19 and C11-oxy C21 steroids have been identified as novel steroids but their function remains unclear. This study aimed to investigate the pre-receptor regulation of C11-oxy steroids by 11β-hydroxysteroid dehydrogenase (11βHSD) interconver
Externí odkaz:
https://doaj.org/article/bf0390691433485985ee442e867a70e8
Intracranial Assessment of Androgen Receptor Antagonists in Mice Bearing Human Glioblastoma Implants
Publikováno v:
International Journal of Molecular Sciences, Vol 25, Iss 1, p 332 (2023)
The median survival time of patients with an aggressive brain tumor, glioblastoma, is still poor due to ineffective treatment. The discovery of androgen receptor (AR) expression in 56% of cases offers a potential breakthrough. AR antagonists, includi
Externí odkaz:
https://doaj.org/article/8eb844b5766e4c4caa8cf2e3de043e64
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Akademický článek
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