Zobrazeno 1 - 10
of 76
pro vyhledávání: '"and Vaclav Janout"'
Publikováno v:
Bioconjug Chem
A strategy is introduced for enhancing the cellular selectivity of Amphotericin B (AmB) and other classes of membrane-disrupting agents. This strategy involves attaching the agent to a molecular umbrella to minimize the disruptive power of aggregated
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::117dd727f9dbd81f1b13782ab917378e
https://doi.org/10.1021/acs.bioconjchem.5b00463
https://doi.org/10.1021/acs.bioconjchem.5b00463
Publikováno v:
Bioconjugate Chemistry
A tetrawalled and an octawalled molecular umbrella conjugate of amphotericin B (AmB) have been synthesized. Both conjugates exhibit high water solubility, a low tendency to aggregate, negligible hemolytic activity at 100 μM, and an ability to releas
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3c932802f5af05c345c70967ec3edc03
http://europepmc.org/articles/PMC4140546
http://europepmc.org/articles/PMC4140546
Autor:
Thomas J. Tucker, Lauren L. Cline, Bradley P. Feuston, David M. Tellers, Vasant Jadhav, Robert L. Peiffer, Sandhya S. Nerurkar, Lynn A. O’Neill-Davis, Steven L. Regen, Vaclav Janout, Yu Yuan, Ann O’Brien, Lee J. Klein
Publikováno v:
Bioconjugate Chemistry
The synthesis, computer modeling, and biological activity of an octawalled molecular umbrella short interfacing RNA (siRNA) conjugate is described. This molecular umbrella-siRNA conjugate exhibited mRNA knockdown activity in vitro in the absence of a
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::eed0788df98a80639c2be2827b3f43b0
https://doi.org/10.1021/bc400506m
https://doi.org/10.1021/bc400506m
Publikováno v:
Langmuir. 26:12988-12993
A homologous series of calix[4]arene-, calix[5]arene-, and calix[6]arene-based surfactants, containing pendant trimethylammonium and n-hexadecyl groups, have been compared with respect to their ability (i) to undergo ionic cross-linking at the air/wa
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b34809a2422a66e905830e40dde9f13f
https://doi.org/10.1021/la1020803
https://doi.org/10.1021/la1020803
Autor:
Mary E. Klotman, Steven L. Regen, Arevik Mosoian, Goar Mosoyan, Ravil R Petrov, Masaharu Kondo, Wen-Hua Chen, Vaclav Janout
Publikováno v:
Bioconjugate Chemistry. 20:1711-1715
A persulfated molecular umbrella derived from one spermine, four lysine, and eight deoxycholic acid molecules was found to exhibit ionophoric activity, as shown by pH discharge and Na(+) and Cl(-) transport experiments. In sharp contrast, a moderatel
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::910c4d25a9202b62d4f6464d35b95f5d
https://doi.org/10.1021/bc900246u
https://doi.org/10.1021/bc900246u
Autor:
Steven L. Regen, Danielle N. Ringhoff, Mohamed Mehiri, Vaclav Janout, Lynne Cassimeris, Bingwen Jing
Publikováno v:
Bioconjugate Chemistry. 19:1510-1513
A fluorescently labeled, persulfated molecular umbrella ( 1) has been synthesized from cholic acid, lysine, spermine, and Coumarin 343 and found capable of entering live HeLa cells. The distributions of 1 throughout the cytoplasm and the nucleus were
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::668742c72a200dfcea03b30f77a36429
https://doi.org/10.1021/bc8001826
https://doi.org/10.1021/bc8001826
Publikováno v:
Macromolecules. 41:497-500
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::158dabeadcf0744faf99997a10f417e0
https://doi.org/10.1021/ma701939p
https://doi.org/10.1021/ma701939p
Publikováno v:
Langmuir. 23:8709-8712
One of the most challenging questions that relates to the structure and function of biological membranes is whether the two halves of the bilayer "talk" to each other. In this letter, we show how the perturbation of the lateral organization of one le
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f6131d4e31e33c2a9fd599a6164cfbef
https://doi.org/10.1021/la701503v
https://doi.org/10.1021/la701503v
Publikováno v:
Langmuir. 22:11224-11229
Langmuir-Blodgett (LB) monolayers of 5,11,17,23,29,35-hexaformyl-37,38,39,40,41,42-hexakis(1-n-octyloxy)-calix[6]arene (2), deposited onto silylated silicon wafers, were cross-linked (i.e., "covalently glued") via Schiff base formation with poly(ally
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d94a66f0df91798dc1a3aec3b048b014
https://doi.org/10.1021/la062573g
https://doi.org/10.1021/la062573g
Publikováno v:
Chemistry of Materials. 18:5065-5069
The introduction of poly(acrylamide) (PAM, Mw 10 000) to an aqueous subphase resulted in increased intermolecular association in the monolayer formed from 5,11,17,23,29,35-hexaamideoxime-37,38,39,40,41,42-hexakis(1-hexadecyloxy) calix[6]arene (2) at
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::04882062dd3c2350f76a1c84ab883d72
https://doi.org/10.1021/cm061750w
https://doi.org/10.1021/cm061750w