Výsledky vyhledávání - "and Timothy P. Puls"

The Chemical Development of CI-972 and CI-1000: A Continuous Nitration, A MgCl2/Et3N-Mediated C-Alkylation of a Chloronitropyrimidine, A Catalytic Protodediazotization of a Diazonium Salt, and an Air Oxidation of an Amine

Autor: Margaret E. Kelly, Philip J. Fiore, Gary J. Dozeman, Randall L. De Jong, Ronald E. Seamans, Punam Giri, James G. Davidson, and Timothy P. Puls

Publikováno v: Organic Process Research & Development. 5:216-225

Efficient, large-scale processes were developed for the preparation of the potent PNP inhibitors 2,6-diamino-3,5-dihydro-7-(3-thienylmethyl)-4H-pyrrolo[3,2-d]pyrimidin-4-one hydrochloride, monohydrate (1) and 2-amino-3,5-dihydro-7-(3-thienylmeth-yl)-

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::b5888302fd97ac7d5a4c3de5ca7ddf5c
https://doi.org/10.1021/op000298d

Zobrazit plný text záznamu

Development and Pilot-Scale Demonstration of a Process for Inhibitors of the HIV Nucleocapsid Protein, NCp7

Autor: Phillip J. Fiore, Walker Jonathan, and Timothy P. Puls

Publikováno v: Organic Process Research & Development. 2:151-156

A manufacturing process to prepare two antiretroviral agents that denature the HIV-1 nucleocapsid protein (NCp7) has been developed and demonstrated on a pilot scale. 2,2‘-Dithiobis(benzoyl chloride) (4), prepared from commercially available 2,2‘

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::ec8b1ba648b6f0111b0095a87293f647
https://doi.org/10.1021/op9701191

Zobrazit plný text záznamu

Chemical Development of a Pilot Scale Process for the ACAT Inhibitor 2,6-Diisopropylphenyl [(2,4,6-Triisopropylphenyl)acetyl]sulfamate

Autor: Gary J. Dozeman, Phillip J. Fiore, and Timothy P. Puls, Walker Jonathan

Publikováno v: Organic Process Research & Development. 1:137-148

A manufacturing process to prepare the ACAT inhibitor 2,6-diisopropylphenyl [(2,4,6-triisopropylphenyl)acetyl]sulfamate (1; CI-1011) has been developed and successfully demonstrated on a pilot scale. Commercially available 1,3,5-triisopropylbenzene (

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::1524bd5da404387d73a705fdcbe13ee1
https://doi.org/10.1021/op9600419

Zobrazit plný text záznamu

ChemInform Abstract: The Chemical Development of CI-972 and CI-1000: A Continuous Nitration, a MgCl2/Et3N-Mediated C-Alkylation of a Chloronitropyrimidine, a Catalytic Protodediazotization of a Diazonium Salt, and an Air Oxidation of an Amine

Autor: Philip J. Fiore, Timothy P. Puls, Ronald E. Seamans, Randall L. De Jong, Margaret E. Kelly, James G. Davidson, Punam Giri, Gary J. Dozeman

Publikováno v: ChemInform. 32

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::5b963162c868cf79220bbd4e67c69246
https://doi.org/10.1002/chin.200143171

Zobrazit plný text záznamu

Vyhledávací nástroje:

Upřesnit hledání