Zobrazeno 1 - 10
of 31
pro vyhledávání: '"and Thomas P. Kissick"'
Autor:
Mayra B. Reyes, Simon Leung, Zenrong Gao, Theo Denzel, Chiajen Lai, Jack Z. Gougoutas, Mark Lindrud, Kevin J. Volk, Thomas P. Kissick, Victor W. Rosso, Gerard A. Crispino, Wei Meng, Pricilla Richberg, Prashant P. Deshpande, William N. Washburn, Mueller Richard H, David Hughes, Hidegard Lobinger, Renee Randazzo, Peter Hans Ermann, Michael E. Randazzo, Wendel W. Doubleday, Michael Fakes, Annie Pullockaran, Frederic G. Buono, Bruce A. Ellsworth, Janak Singh, John D. Dimarco
Publikováno v:
Organic Process Research & Development. 16:577-585
A practical synthesis of the SGLT-2 inhibitor β-C-aryl-d-glucoside (1) has been developed. The route employed 2,3,4,6-tetra-O-trimethlysilyl-d-glucano-1,5-lactone as the key chiral building block, prepared efficiently from the commercially available
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::b1fbf64e633a66849c3bae734a3b4e43
https://doi.org/10.1021/op200306q
https://doi.org/10.1021/op200306q
Autor:
Thomas P. Kissick, Animesh Goswami
Publikováno v:
Organic Process Research & Development. 13:483-488
An efficient process for the synthesis of the monoester, (1S,2R)-2-(methoxycarbonyl)cyclohex-4-ene-1-carboxylic acid by Candida antarctica lipase (Novozym 435)-catalyzed desymmetrization of the corresponding diester, dimethyl-cyclohex-4-ene-cis-1,2-d
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::4129686c7121dcf4c2b9334ed92e2fcf
https://doi.org/10.1021/op8002954
https://doi.org/10.1021/op8002954
Autor:
Joseph Wurdinger, Theodor Denzel, Janak Singh, Chris G. Papaioannou, Richard H. Mueller, Rita Fox, Rolf Herter, Peter Schierling, Thomas P. Kissick, Jerome L. Moniot, Christopher M. Cimarusti
Publikováno v:
Organic Process Research & Development. 6:863-868
An efficient synthesis of the monobactam aztreonam [[2S-[2α,3β(Z)]]-3[[(2-amino-4-thiazolyl)[(1-carboxy-1-methylethoxy)imino]acetyl]amino]-2-methyl-4-oxo-1-azetidinesulfonic acid] (1) by acylation of α-aminoazetidinone 22 with the regioselectively
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::5d886af18b59af7bb47f35d3554c9f40
https://doi.org/10.1021/op025572d
https://doi.org/10.1021/op025572d
Process Research and Development for an Efficient Synthesis of the HIV Protease Inhibitor BMS-232632
Autor:
James E. Heikes, Mark D. Schwinden, Mark Lindrud, Michael J. Humora, Fernando Quiroz, David R. Kronenthal, Thomas P. Kissick, Bharat P. Patel, Sushil K. Srivastava, Dau-Ming Hsieh, Lin Dong, Janak Singh, Bin Zheng, Pudipeddi Madhusudhan, Zhongmin Xu, Richard H. Mueller
Publikováno v:
Organic Process Research & Development. 6:323-328
Development of an efficient and scalable process for the human immunodeficiency virus (HIV) protease inhibitor BMS-232632 1-[4-(pyridin-2-yl)phenyl]-5(S)-2,5-bis{[N-(methoxycarbonyl)-l-tert-leucinyl]-amino}-4(S)-hydroxy-6-phenyl-2-azahexane, is descr
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::50179c1c32a843ef9b7343fecb8439b4
https://doi.org/10.1021/op025504r
https://doi.org/10.1021/op025504r
Autor:
John D. Dimarco, Shankar Swaminathan, Brian Burke, Thomas P. Kissick, Oak K. Kim, Bin Zheng, Janak Singh, Kenneth J. Natalie, Goodrich Jason, Juliya Livshits, Matthew A. Brown, John A. Grosso, Zhinong Gao, Michael J. Humora, Anthony P. Dutka, Peter Hans Ermann, David R. Kronenthal, Gerard A. Crispino, Richard H. Mueller, John A. Wichtowski, Jeffrey T. North, Joanne J. Bronson, Jack Z. Gougoutas, Yasutsugu Ueda, Dane M. Springer, Peter Schierling, Bing Yu Luh, James E. Heikes, Dau-Ming Hsieh, Anne J. Pullockaran, Bo Zhang, Robert K. Perrone, Mei C. Lai, and Theodor W. Denzel, Yunhui Zhang
Publikováno v:
Organic Process Research & Development. 4:488-497
A practical synthesis of the anti-methicillin resistant Staphylococcus aureus cephem (6R-trans)-E-7-[[[[2,5-dichloro-4-[3-[(carboxymethyl)amino]-3-oxo-1-propenyl]phenyl]-thio]-acetyl]amino]-4-[[(2-carboxy-8-oxo-5-thia-1-azabicyclo-[4.2.0]oct-2-en-3-y
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::030fc232263c59de1340816a124920ab
https://doi.org/10.1021/op0002850
https://doi.org/10.1021/op0002850
Autor:
John A. Wichtowski, Yuan Tsai, Ken Denbleyker, Peter F. Misco, Jollie D. Godfrey, Janak Singh, Raymond F. Miller, Junius M. Clark, John D. Matiskella, Michael J. Pucci, Richard H. Mueller, Michael J. Humora, Boyhan Brenda T, Thomas P. Kissick, Joan Fung-Tomc, Stan V. D'Andrea, David R. Kronenthal, Robert K. Perrone, Yasutsuga Ueda, Annie Pullockaran, Murray A. Kaplan, Sterzycki Roman Z, James E. Heikes, Shelley E. Hoeft, Fritz Alan W, Truc Chi Vu, Rita Fox, Joanne J. Bronson, Jeffery T. North, D P Bonner, Thomas W. Hudyma
Publikováno v:
Tetrahedron. 56:5687-5698
Cephalosporin derivatives containing a unique combination of lipophilic C-7 sidechains and polar C-3 thiopyridinium groups were synthesized and found to exhibit potent anti-MRSA activity in vitro and in vivo. The optimum C-7 sidechains utilized were
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::625ad66e9507d6b330714a80db975bfd
https://doi.org/10.1016/s0040-4020(00)00418-x
https://doi.org/10.1016/s0040-4020(00)00418-x
Autor:
Mueller Richard H, Saleem Ahmad, Truc Chi Vu, O. Kocy, Gregory S. Bisacchi, Thomas P. Kissick, Janak Singh, Toomas Mitt, and Robert Zahler, James E. Heikes, Chris G. Papaioannou, Michael K. Wong, Jollie D. Godfrey
Publikováno v:
Organic Process Research & Development. 2:393-399
A practical synthesis of the antiviral agent lobucavir, [1R-(1α,2β,3α)]-2-amino-9-[2,3-bis(hydroxymethyl)cyclobutyl]-6H-purin-6-one (BMS-180194), is described. The key chiral intermediate, [1S-(1α,2β,3α)]-3-hydroxy-1,2-cyclobutanedimethanol, di
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9422289371c492f52c68da1ed5a58c59
https://doi.org/10.1021/op970214+
https://doi.org/10.1021/op970214+
Autor:
Michael A. Poss, and Thomas P. Kissick, Michael J. Humora, Pansegrau Paul D, Boyhan Brenda T, Richard H. Mueller, John K. Thottathil, Shaopeng Wang, Janak Singh, Joy Q. Jannotti
Publikováno v:
Organic Process Research & Development. 1:14-19
A novel and highly efficient synthesis of [1S-(1α,2α,3α,4α)]-2-[[2-(3-methoxy-3-oxopropyl)phenyl]methyl]-7-oxabicyclo[2.2.1]heptane-3-carboxylic acid (A), a key intermediate in the synthesis of ifetroban sodium, BMS-180291, is described. Reaction
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::c18c7f149f12d9bc912e67332555272d
https://doi.org/10.1021/op960034k
https://doi.org/10.1021/op960034k
Autor:
Janak Singh, Jollie D. Godfrey, Thomas P. Kissick, Mary F. Malley, Gregory S. Bisacchi, Robert Zahler, Toomas Mitt, Jack Z. Gougoutas, Mueller Richard H, John D. Di Marco
Publikováno v:
The Journal of Organic Chemistry. 60:2902-2905
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::b389aeb41f3331afca485bd1fed22ad5
https://doi.org/10.1021/jo00114a047
https://doi.org/10.1021/jo00114a047
Autor:
Richard H. Mueller, Janak Singh, Thomas P. Kissick, Joel C. Barrish, David R. Kronenthal, Steven H. Spergel, Wei Han
Publikováno v:
ChemInform. 24
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::a05cde084a318047e1de456a2e22dd34
https://doi.org/10.1002/chin.199349179
https://doi.org/10.1002/chin.199349179