Zobrazeno 1 - 10
of 61
pro vyhledávání: '"and Stephen F. Betz"'
Publikováno v:
Frontiers in Endocrinology, Vol 13 (2022)
Congenital hyperinsulinism (CHI), although a rare disease, is an important cause of severe hypoglycemia in early infancy and childhood, causing preventable morbidity and mortality. Prompt diagnosis and appropriate treatment is necessary to prevent hy
Externí odkaz:
https://doaj.org/article/0e5eca2594bd4225893fb93a46fa8bb5
Autor:
Jian Zhao, Shimiao Wang, Stacy Markison, Sun Hee Kim, Sangdon Han, Mi Chen, Ana Karin Kusnetzow, Elizabeth Rico-Bautista, Michael Johns, Rosa Luo, R. Scott Struthers, Ajay Madan, Yunfei Zhu, Stephen F. Betz
Publikováno v:
ACS Medicinal Chemistry Letters. 14:66-74
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::3a11c0a55f0670850cd8a44d1e01d93a
https://doi.org/10.1021/acsmedchemlett.2c00431
https://doi.org/10.1021/acsmedchemlett.2c00431
Autor:
Christine A. Juliana, Jinghua Chai, Pablo Arroyo, Elizabeth Rico-Bautista, Stephen F. Betz, Diva D. De León
Publikováno v:
Journal of Biological Chemistry. :104816
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::eb76139da828a62a927fc869e03ab404
https://doi.org/10.1016/j.jbc.2023.104816
https://doi.org/10.1016/j.jbc.2023.104816
Autor:
Elizabeth Rico-Bautista, Joseph Pontillo, Shimiao Wang, Agnes S Antwan, Pablo Arroyo, Beth Fleck, Melissa A Fowler, Greg Reinhart, Michael A Johns, Ana K Kusnetzow, Yun Fei Zhu, Stacy Markison, Stephen F Betz
Publikováno v:
Journal of the Endocrine Society. 6:A151-A152
Hypercalcemia is a common disorder defined as a serum calcium concentration higher than the normal range of 8.5 - 10.5 mg/dL. The most common causes of hypercalcemia are over-secretion of parathyroid hormone (PTH) from one or more enlarged parathyroi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::42ed107f1ec34d893aef4810a6caa3af
https://doi.org/10.1210/jendso/bvac150.309
https://doi.org/10.1210/jendso/bvac150.309
Autor:
Julie B. Nguyen, Ana K. Kusnetzow, Greg Reinhart, Sun Hee Kim, R. S. Struthers, Yun Fei Zhu, Stephen F. Betz
Publikováno v:
The FASEB Journal. 36
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::3ed6884c1b803d0e99d7697c6b9ebd9b
https://doi.org/10.1096/fasebj.2022.36.s1.r2027
https://doi.org/10.1096/fasebj.2022.36.s1.r2027
Autor:
Jian Zhao, Shimiao Wang, Sun Hee Kim, Sangdon Han, Elizabeth Rico-Bautista, Emmanuel Sturchler, Julie Nguyen, Hannah Tan, Christine Staley, Ana Karin Kusnetzow, Stephen F. Betz, Michael Johns, Lance Goulet, Rosa Luo, Melissa Fowler, Jon Athanacio, Stacy Markison, R. Scott Struthers, Yunfei Zhu
Publikováno v:
Bioorganicmedicinal chemistry letters. 71
SST5 receptor activation potently inhibits insulin secretion from pancreatic β-cells, and an orally available nonpeptide selective SST5 agonist may be used to effectively manage the blood glucose levels of congenital HI patients to avoid severe hypo
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::08412728bd9e34f60beabf7d56a84d5c
https://pubmed.ncbi.nlm.nih.gov/35605837
https://pubmed.ncbi.nlm.nih.gov/35605837
Autor:
Ajay Madan, Stacy Markison, Stephen F. Betz, Alan Krasner, Rosa Luo, Theresa Jochelson, Jason Lickliter, R. Scott Struthers
Publikováno v:
Pituitary. 25(2)
Purpose Evaluate the pharmacodynamics, pharmacokinetics, and safety of paltusotine, an orally bioavailable, nonpeptide, somatostatin receptor subtype 2 (SST2) agonist being developed for the treatment of acromegaly and neuroendocrine tumors. Methods
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b20574ba53c22e9b6dc20890c869cb90
https://pubmed.ncbi.nlm.nih.gov/35000098
https://pubmed.ncbi.nlm.nih.gov/35000098
Autor:
R. Scott Struthers, Stephen F. Betz, Taylor Kredel, Shirley Cruz, Melissa Fowler, Michael Johns, Jon Athanacio, Agnes Antwan, Stacy Markison, Ajay Madan, Greg J. Reinhart, Oleg Tsivkovski, Ana Karin Kusnetzow, Rosa Luo
Publikováno v:
Endocrine Abstracts.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::411392deaa7a8946edaca3d8a1d926c8
https://doi.org/10.1530/endoabs.70.oc6.1
https://doi.org/10.1530/endoabs.70.oc6.1
Autor:
Sun Hee Kim, Taylor Kredel, Rosa Luo, Christine Staley, Ana Karin Kusnetzow, Jon Athanacio, Yun Fei Zhu, Stephen F. Betz, Melissa Fowler, Elizabeth Rico, Ajay Madan, Stacy Markison, Greg J. Reinhart, Agnes Antwan, Oleg Tsivkovski, Hannah Tan, Sangdon Han, Scott Struthers, Michael Johns, Julie Nguyen
Publikováno v:
Journal of the Endocrine Society
Adrenocorticotropic hormone (ACTH) is an important modulator of steroidal hormone synthesis and secretion from the adrenal gland and its selective activity at the melanocortin type 2 receptor (MC2) dictates the synthesis and secretion of cortisol (co
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fe9cebfe2f5611637b080fce0b48971a
http://europepmc.org/articles/PMC7209750
http://europepmc.org/articles/PMC7209750
Autor:
Melissa Fowler, Taylor Kredel, Rosa Luo, Stacy Markison, Shirley Cruz, Ana Karin Kusnetzow, Stephen F. Betz, Scott Struthers, Oleg Tsivkovski, Michael Johns, Agnes Antwan, Greg J. Reinhart, Jon Athanacio, Ajay Madan
Publikováno v:
Journal of the Endocrine Society
Cushing’s disease (CD) and Ectopic ACTH syndrome (EAS) stem from excess circulating adrenocorticotropic hormone (ACTH) and resulting hypercortisolemia. In CD, excess ACTH is secreted from pituitary tumors, whereas excess ACTH in EAS arises from non
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6cabd2ca03573ef4171b9289897a6290
http://europepmc.org/articles/PMC7209714
http://europepmc.org/articles/PMC7209714