Zobrazeno 1 - 10
of 13
pro vyhledávání: '"and Shoeb I. Khan"'
Autor:
Jenna Wilson, Debra G Wheeler, Laura J. Sommerville, David Dornbos, Kendyl Carlisle, Nicholas Venetos, Richard C. Becker, Shahid M Nimjee, Juliana M. Layzer, George A. Pitoc, Nicholas Musgrave, Allyson Huttinger, Spencer Talentino, Shoeb I. Khan, Holly Moody, Bruce A. Sullenger, Jay L. Zweier, Camille Bratton, Rachel E. Rempel, Matthew Joseph, Maureane Hoffman, Cheyenne Jones
Publikováno v:
Mol Ther
Endothelial surface and circulating glycoprotein von Willebrand factor (vWF) regulates platelet adhesion and is associated with thrombotic diseases, including ischemic stroke, myocardial infarction, and peripheral vascular disease. Thrombosis, as man
Publikováno v:
Inorganic Chemistry. 38:3922-3925
A facile procedure for the incorporation of Ru(bpy)32+ in an oligonucleotide is reported. A Ru(bpy)32+ phosphoramidite is synthesized, and then attached to the 5‘-terminus of DNA using a standard protocol on an automated DNA solid-phase synthesizer
Publikováno v:
Inorganic Chemistry. 38:2411-2415
The synthesis and photophysical properties of a novel ruthenium-modified nucleoside are reported. The key synthetic step to 5-[Ru(bpy)2(4-m-4‘-pa-bpy)]2+-2‘-deoxyuridine involves the Pd(0)-catalyzed cross-coupling of a propargylamine-derivatized
Autor:
Shoeb I. Khan, Mark W. Grinstaff
Publikováno v:
Tetrahedron Letters. 39:8031-8034
The solid-phase synthesis of a nucleoside hydroxamic acid is accomplished by the Pd(0) cross-coupling of 5-iodouridine and an O-linked hydroxylamine alkyne bound to 2-chlorotrityl chloride polystyrene resin.
Publikováno v:
Nucleosides and Nucleotides. 13:1049-1058
Synthesis and antifungal activity of 3′-deoxyribo-nucleosides containing naturally occurring pyrimidine and purine bases are reported.
Autor:
Mark W. Grinstaff, Shoeb I. Khan
Publikováno v:
ChemInform. 30
Publikováno v:
The Journal of Physical Chemistry B. 104:7574-7576
Kinetics of a photoinduced electron-transfer reaction between phenothiazine (PTZ) and Ru(bpy)2(4-m-4‘-pa-bpy)2+ [bpy = 2,2‘-bipyridine and 4-m-4‘-pa-bpy = 4-methyl-4‘-carbonylpropargylamine] covalently bound to a DNA duplex is investigated by
Publikováno v:
Nucleosides, nucleotidesnucleic acids. 24(5-7)
The 5-ethynyl-2'-deoxyuridine nucleoside and the 5'-boranomonophosphate nucleotide were synthesized as analogs of 5-fluoro-2'-deoxyuridine monophosphate (5-FdUMP), a widely used mechanism-based inhibitor of thymidylate synthase. Synthesis was carried
Autor:
Thomas L. Ortel, Richard C. Becker, Deborah A. Lewis, Shahid M Nimjee, Shoeb I. Khan, George A. Pitoc, Bruce A. Sullenger
Publikováno v:
Blood. 124:4279-4279
Introduction: Many cardiovascular procedures including percutaneous coronary intervention, coronary bypass surgery, and peripheral vascular surgery require antithrombotic therapy during the procedure. Heparin is frequently used, due to low cost, ease
Publikováno v:
Inorganic chemistry. 38(26)
A facile procedure for incorporating a Ru(diimine)(3)(2+) complex at the nucleobase in an oligonucleotide is reported that combines the advantages of Pd(0) cross-coupling and solid-phase DNA chemistries. These ruthenium-modified oligonucleotides form