Zobrazeno 1 - 10
of 19
pro vyhledávání: '"and Ruth E. McDermott"'
Autor:
Peter Robert Rose, Denis Lynch, David B. Damon, Darragh Breen, Nga M. Do, Busch Frank R, John A. Ragan, Maria M. O’Sullivan, Eric M. Cordi, Joseph A. Mongillo, Brian C. Vanderplas, Jon Blunt, Ruth E. McDermott, Dennis E. Bourassa, Alanya Engtrakul
Publikováno v:
Organic Process Research & Development. 13:186-197
Development of an efficient bond-forming sequence and optimization of reaction conditions are described for the synthesis of CP-945,598-01 (1·HCl), a CB1 antagonist in clinical studies for the treatment of obesity. Reordering of the bond-forming seq
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::83d0f4ddf324d49a16e57d95f896a5f2
https://doi.org/10.1021/op800255j
https://doi.org/10.1021/op800255j
Publikováno v:
Organic Process Research & Development. 10:257-261
CP-885,316 (1), an imidazo[4,5-c]pyridine, 4, was prepared from 3,4-diaminopyridine (9). Two routes were demonstrated using the regioselective introduction of either an acetamide at the 3-position or a tert-butylcarbamate at the 4-position.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::37d3f82716afcf8c5f55cf45621c0845
https://doi.org/10.1021/op0502250
https://doi.org/10.1021/op0502250
Autor:
Michel Couturier, Paul Bowles, Morgan Meltz, Robert A. Singer, Gregory Lee Karrick, Lulin Wei, Meltz Clifford Nathaniel, John A. Ragan, Ruth E. McDermott, Dennis E. Bourassa, James E. Phillips, Michael J. Castaldi, Ronald J. Clay, Justin Beaudin, John L. Tucker, Teresa W. Makowski, David H. Brown Ripin
Publikováno v:
Organic Process Research & Development. 7:873-878
The synthesis of 6-ethoxy-4-oxo-1,4-dihydro-[1,5]naphthyridine-3-carboxylic acid benzylamide (1) on multikilogram scale is described. The major challenge for the synthesis of this quinolone GABA partial agonist was in the isolation of product of acce
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::15ad0142e3b287ae0fdbef95483ccc4e
https://doi.org/10.1021/op0341061
https://doi.org/10.1021/op0341061
Autor:
John A. Ragan, Paul D. Hill, Y. Lu, Ruth E. McDermott, Jonathan L. Doty, Beth Cooper, Matthew A. Marx, Brian P. Jones, Raggon Jeffrey W, Michael John Munchhof, Jeffrey M. Casavant
Publikováno v:
Organic Process Research & Development. 7:676-683
The multihundred-gram synthesis of [2-(3-methyl-3H-imidazol-4-yl)-thieno[3,2-b]pyridin-7-yl]-(2-methyl-1H-indol-5-yl)-amine (1) is described utilizing a Stille cross-coupling of an iodothienopyridine (3) with 5-(tributylstannyl)-1-methylimidazole (11
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::45a928599c0a3c7bfa22e938875f6ab3
https://doi.org/10.1021/op0340457
https://doi.org/10.1021/op0340457
Publikováno v:
Synthesis. 2003:1727-1731
Two families of biarylphosphine ligands were prepared for use in the Pd-catalyzed amination reaction. The first series investigated was derived from N-phenylpyrroles, and the second, was derived from N-phenylpyrazoles. While the pyrrole ligands were
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::4b7fd020ff2c4bc7e324faf1298d45ce
https://doi.org/10.1055/s-2003-40881
https://doi.org/10.1055/s-2003-40881
Autor:
Johnson Michael R, P. L. Kelbaugh, Ruth E. McDermott, W. H. Kappeler, P. Merrigan, Gerald F. Holland, David Alan Clark, R W Stevenson, F. J. Rajeckas, Bernard Hulin, James F. Eggler, R. T. Suleske, E. M. Gibbs, Robert A. Volkmann, D. K. Kreutter, N. J. Hutson, D. L. Tickner, C. H. Lamphere, M. N. Krupp, E. G. Andrews, Steven W. Goldstein
Publikováno v:
ChemInform. 22
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::f8806d27fd0a2539a30e0c2a738d614a
https://doi.org/10.1002/chin.199124153
https://doi.org/10.1002/chin.199124153
Publikováno v:
ChemInform. 23
2-Aminobenzophenones and acetophenones were N-acylated with α-azido carboxylic acids to give the corresponding anilides. Reductive cyclization provided 3-substituted-2H-1,4-benzodiazepin-2-ones in good (46–99%) yields.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::3bed6061d10cccfb6c2dfed24adbb6c1
https://doi.org/10.1002/chin.199225192
https://doi.org/10.1002/chin.199225192
Autor:
W. H. Kappeler, Ruth E. McDermott, Diana M. Lewis, David Alan Clark, Bernard Hulin, James P. Rizzi, Paul J. Dambek, C. H. Lamphere, Steven W. Goldstein
Publikováno v:
ChemInform. 24
A new series of thiazolidine-2,4-diones was obtained by replacing the ether function of englitazone with various functional groups, i.e., a ketone, alcohol, or olefin moiety. These compounds lower blood glucose levels in the genetically obese and ins
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::ff045d1d1196daf3eb7be55102688f45
https://doi.org/10.1002/chin.199301186
https://doi.org/10.1002/chin.199301186
Autor:
David Alan Clark, James P. Rizzi, W. H. Kappeler, Bernard Hulin, Paul J. Dambek, Ruth E. McDermott, Diana M. Lewis, Steven W. Goldstein, C. H. Lamphere
Publikováno v:
Journal of Medicinal Chemistry. 35:1853-1864
A new series of thiazolidine-2,4-diones was obtained by replacing the ether function of englitazone with various functional groups, i.e., a ketone, alcohol, or olefin moiety. These compounds lower blood glucose levels in the genetically obese and ins
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::58a398671652f0cc7a6aff6a1b6d929e
https://doi.org/10.1021/jm00088a022
https://doi.org/10.1021/jm00088a022
Autor:
Pamela J. Clifford, Spiros Liras, Ruth E. McDermott, David J. am Ende, John A. Ragan, Steven D. Heck, Stanton J. McHardy, Brian P. Jones, Barb E. Segelstein
Publikováno v:
Synlett. 2000:1172-1174
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::7e74755cc28c8c6868ed3123d8b80462
https://doi.org/10.1055/s-2000-6749
https://doi.org/10.1055/s-2000-6749