Zobrazeno 1 - 10
of 40
pro vyhledávání: '"and Robert B. Nachbar"'
Publikováno v:
PLoS Computational Biology, Vol 3, Iss 9, Pp 1819-1826 (2007)
Physicochemical models of signaling pathways are characterized by high levels of structural and parametric uncertainty, reflecting both incomplete knowledge about signal transduction and the intrinsic variability of cellular processes. As a result, t
Externí odkaz:
https://doaj.org/article/bfb39b0aeb3444ffa4ca80d07d39c2c3
Autor:
Robert B. Nachbar, John A. Wagner, Deborah Panebianco, Valentin S. Moiseev, Zhanna Kobalava, Edward Gane, Christina Reitmann, Sorin Visan, Kristien Van Dyck, Frank J. Dutko, Martine Robberechts, Inge De Lepeleire, Wendy W. Yeh, Andreas Hüser, Zifang Guo, Christian Schwabe, Joan R. Butterton, Edward O'Mara, Markus Uhle, Iain P. Fraser, Xiaobi Huang, Nelea Ghicavii, Patricia Jumes, Serghei Popa, Amelia S. Petry, Frank Wagner
Publikováno v:
Clinical Therapeutics. 40:704-718.e6
Purpose Elbasvir (MK-8742) and grazoprevir (MK-5172; Merck & Co, Inc, Kenilworth, New Jersey) are hepatitis C virus (HCV)-specific inhibitors of the nonstructural protein 5A phosphoprotein and the nonstructural protein 3/4A protease, respectively. Th
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::859e887a63702d1bb18e52d8097ed5ca
https://doi.org/10.1016/j.clinthera.2018.03.002
https://doi.org/10.1016/j.clinthera.2018.03.002
Autor:
James A. Bailey, Ansuman Bagchi, Robert B. Nachbar, Leah Edelstein-Keshet, Adam J. Simon, Jacquelynn J. Cook, Richard Hargreaves, Jeffrey Saltzman, Daniel Coombs, Raibatak Das, Matthew C. Wiener
Publikováno v:
Bulletin of Mathematical Biology. 73:230-247
Aggregation of the small peptide amyloid beta (Aβ) into oligomers and fibrils in the brain is believed to be a precursor to Alzheimer’s disease. Aβ is produced via multiple proteolytic cleavages of amyloid precursor protein (APP), mediated by the
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::822b578c16e3870a66a472bcc216e5c8
https://doi.org/10.1007/s11538-010-9540-5
https://doi.org/10.1007/s11538-010-9540-5
Autor:
Rhonda A. Torres, Kenneth R. Korzekwa, Robert B. Nachbar, Deborah L. Dooney, Robert P. Sheridan, Daniel R. McMasters, Susan J. Crathern
Publikováno v:
Journal of Medicinal Chemistry. 50:3205-3213
The affinities of a diverse set of 500 drug-like molecules to cytochrome P450 isoforms 2C9 and 2D6 were measured using recombinant expressed enzyme. The dose–response curve of each compound was fitted with a series of equations representing typical
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::654cc363c77b3e4ce9c6e2ef5b370a49
https://doi.org/10.1021/jm0700060
https://doi.org/10.1021/jm0700060
Autor:
Luzelena Caro, D. Hamish Wright, John A. Wagner, Robert B. Nachbar, Andrew H. Talal, Melanie Anderson, Michael Cerra, Lihong Du, Andrej Potthoff, Michael P. Manns, Paul Panorchan
Publikováno v:
Antiviral therapy. 20(8)
Background Some drugs that are actively taken up into the liver exhibit greater than dose proportional increases in plasma exposure, although human liver-to-plasma concentration ratios have rarely been evaluated. Understanding these relationships has
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e99baed9697b22174d6840c2b31b1dc2
https://pubmed.ncbi.nlm.nih.gov/25849338
https://pubmed.ncbi.nlm.nih.gov/25849338
Publikováno v:
Journal of Essential Oil Research. 14:156-160
In continuation of our investigation of aromatic flora of the Holy Land, the systematic study of Artemisia herba alba essential oils has been conducted. The detailed composition of five relatively rare chemotypes of A. herba alba obtained through GC
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::55b16916cece783c96db934324dd78e0
https://doi.org/10.1080/10412905.2002.9699809
https://doi.org/10.1080/10412905.2002.9699809
Autor:
Bradley P. Feuston, and Robert B. Nachbar, Michael D. Miller, Simon K. Kearsley, J. Christopher Culberson
Publikováno v:
Journal of Chemical Information and Computer Sciences. 41:754-763
A knowledge-based approach for generating conformations of molecules has been developed. The method described here provides a good sampling of the molecule's conformational space by restricting the generated conformations to those consistent with the
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1ffa0010d905103efd7a1108abd5bff4
https://doi.org/10.1021/ci000464g
https://doi.org/10.1021/ci000464g
Autor:
Robert B. Nachbar, Suresh B. Singh, Eugene M. Fluder, Robert P. Sheridan, Richard D. Hull, Simon K. Kearsley
Publikováno v:
Journal of Medicinal Chemistry. 44:1177-1184
A novel method for computing chemical similarity from chemical substructure descriptors is described. This new method, called LaSSI, uses the singular value decomposition (SVD) of a chemical descriptor-molecule matrix to create a low-dimensional repr
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2032e7697568fbaa5cf64b77fbcbe348
https://doi.org/10.1021/jm000393c
https://doi.org/10.1021/jm000393c
Autor:
Robert B. Nachbar, Eugene M. Fluder, Suresh B. Singh, Simon K. Kearsley, Robert P. Sheridan, Richard D. Hull
Publikováno v:
Journal of Medicinal Chemistry. 44:1185-1191
Similarity searches based on chemical descriptors have proven extremely useful in aiding large-scale drug screening. Here we present results of similarity searching using Latent Semantic Structure Indexing (LaSSI). LaSSI uses a singular value decompo
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6b879105cf0da0050ea41bc5f0e6ee9f
https://doi.org/10.1021/jm000392k
https://doi.org/10.1021/jm000392k
Autor:
Robert B. Nachbar
Publikováno v:
Genetic Programming and Evolvable Machines. 1:57-94
A simple hierarchical data structure (tree) and associated set of algorithms (written in Mathematica) have been developed that permit the direct manipulation of the topology of a molecule while simultaneously maintaining valid chemical valence. Coupl
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::d9fc1b1e6e4362726e2d947f6dd321ce
https://doi.org/10.1023/a:1010072431120
https://doi.org/10.1023/a:1010072431120