Zobrazeno 1 - 10
of 38
pro vyhledávání: '"and Ray McCague"'
The use of a thermostable signature amidase in the resolution of the bicyclic synthon (rac)-γ-lactam
Autor:
K. Line, Ray McCague, Rob C. Brown, Stephen Taylor, Helen S. Toogood, Jennifer A. Littlechild, Phil A Keene
Publikováno v:
Tetrahedron. 60:711-716
The resolution of the bicyclic synthon ( rac )-γ-lactam (2-azabicyclo[2.2.1]hept-5-en-3-one) is an important step in the synthesis of a group of chemotherapuetic agents known as carbocyclic nucleosides. The archaeon Sulfolobus solfataricus MT4 produ
Autor:
Stephen Taylor, Rob C. Brown, Helen S. Toogood, Ray McCague, Ian N. Taylor, Jennifer A. Littlechild
Publikováno v:
Biocatalysis and Biotransformation. 20:241-249
A thermostable archaeal l -aminoacylase from Thermococcus litoralis has been used in immobilisation trials to optimise its application in industrial biotransformation reactions. Immobilisation techniques used included direct adsorption and crosslinki
Publikováno v:
Journal of the Chemical Society, Perkin Transactions 1. :515-525
Several N-arylsulfonylglycine esters have been brominated under photolytic conditions to provide the corresponding α-bromoglycine. These bromo esters can be treated with a range of bases to generate N-sulfonyl imino esters in situ; attempts to isola
Publikováno v:
Tetrahedron Letters. 40:6109-6112
A catecholborane mediated reaction of the lactam epoxide unexpectedly gave the cis-diol a useful intermediate for adenosine agonists. The origin of this reaction is postulated to arise from the formation of a boronic anhydride which is transferred to
Publikováno v:
ResearcherID
Tosyl cyanide is activated by titanium(IV) chloride to generate a tolylsulfinyl chloride equivalent, which readily stereo- and regio-specifically adds to certain alkenes to provide β-chlorosulfoxides. These chlorides rapidly hydrolyse on silica gel
Publikováno v:
The Journal of Organic Chemistry. 63:7183-7189
The Baylis-Hillman reaction, the coupling of an unsaturated carbonyl compound/nitrile with aldehydes, is a valuable reaction but is limited in its practicality by poor reaction rates. We have endeavored to accelerate the reaction using Lewis acids an
Autor:
Graham Ruecroft, Robin Mark Bannister, and Ray McCague, Neil Henderson, Christopher H. Hanson
Publikováno v:
Organic Process Research & Development. 1:415-419
The synthesis of [3aR,4S,6R,6aS]-6-amino-N-ethyltetrahydro-2,2-dimethyl-4H-cyclopenta-1,3-dioxole-4-carboxamide, a key single enantiomer intermediate to carbocyclic nucleosides such as adenosine agonists, is reported involving a scalable catalytic os
Publikováno v:
The Journal of Organic Chemistry. 62:4665-4671
The palladium-catalyzed nucleophilic substitution of C-4-substituted 2-oxabicyclo[3.3.0]oct-7-en-3-ones (unsaturated, fused lactones) have been studied particularly in relation to how electronic and steric factors influenced the rate and efficiency o
Autor:
A. Rawas, Herman C. Watson, P. McMichael, G. Lewis, Jennifer A. Littlechild, Ray McCague, J. Bevan, Wisdom Richard Anthony
Publikováno v:
Acta Crystallographica Section D Biological Crystallography. 53:348-351
As part of the programme to understand the mechanism and specificity of lipase enzymes used in biotransformation reactions, the lipase from Candida cylindracea has been purified and crystallized. This lipase has been widely used by organic chemists f
Autor:
Ray McCague, Valeria Merlo, Antonio Garofalo, Stanley M. Roberts, Jennifer M. L. Hillman, Alex F. Drake
Publikováno v:
J. Chem. Soc., Perkin Trans. 1. :2739-2745
The epoxycyclopentanol 10 is converted into the methylphosphonate 15 in 30% overall yield. The diol 15 is converted into the protected carbocyclic nucleotide mimics 16, 18, 21 and 22 in 38–70% yield. The diol 15 is resolved using a lipase-catalysed