Zobrazeno 1 - 10
of 78
pro vyhledávání: '"and P. David Josephy"'
Autor:
J. Robert Beecroft, Savtaj Brar, Xiaolan Feng, Trevor Hamilton, Cheng Han-Lee, Jan-Willem Henning, P. David Josephy, Korosh Khalili, Yoo-Joung Ko, Christopher Lemieux, David M. Liu, D. Blair MacDonald, Jonathan Noujaim, Aaron Pollett, Abdulazeez Salawu, Ramy Saleh, Alannah Smrke, Blair E. Warren, Kevin Zbuk, Albiruni Abdul Razak
Publikováno v:
Therapeutic Advances in Medical Oncology, Vol 16 (2024)
Gastrointestinal stromal tumours (GISTs) are mesenchymal tumours that originate from the interstitial cells of Cajal. GISTs are mainly driven by gain-of-function mutations in receptor tyrosine kinase or platelet-derived growth factor receptor alpha.
Externí odkaz:
https://doaj.org/article/73ebf25c2ec54ada94f29107610fcdf0
Autor:
Richard A. Manderville, Ryan W. Kung, Stacey D. Wetmore, M. Sameer Al-Abdul-Wahid, P. David Josephy, Trevor W. Manning
Publikováno v:
Chemical Research in Toxicology. 33:584-593
Nitroaromatic compounds represent a major class of industrial chemicals that are also found in nature. Polycyclic derivatives are regarded as potent mutagens and carcinogens following bioactivation...
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::8369272db8d60e6f45daeda10606f51a
https://doi.org/10.1021/acs.chemrestox.9b00411
https://doi.org/10.1021/acs.chemrestox.9b00411
Autor:
Lamia Benbrahim-Tallaa, Guosheng Chen, Consolato Sergi, Nancy B. Hopf, Lin Fritschi, Gloria M. Calaf, Eero Suonio, Felicia Fei-Lei Chung, Ian A. Cree, Karen Müller, Tina Bahadori, Mary K. Schubauer-Berigan, Heidi Mattock, Damien McElvenny, Fatiha El Ghissassi, Sophie Langouët, Kristina Kjaerheim, Yann Grosse, William M. Gwinn, Aline de Conti, David M. DeMarini, Tania Carreón-Valencia, Takeshi Toyoda, Kathryn Z. Guyton, Jorunn Kirkeleit, Martha S. Sandy, Min Gi, Michelle C. Turner, P. David Josephy, Leslie T. Stayner
Publikováno v:
The Lancet Oncology. 21:1017-1018
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::75bfafdafbfc7ea1a68024ba68474391
https://doi.org/10.1016/s1470-2045(20)30375-2
https://doi.org/10.1016/s1470-2045(20)30375-2
Autor:
Trevor W, Manning, M Sameer, Al-Abdul-Wahid, Richard A, Manderville, P David, Josephy, Ryan W, Kung, Stacey D, Wetmore
Publikováno v:
Chemical research in toxicology. 33(2)
Nitroaromatic compounds represent a major class of industrial chemicals that are also found in nature. Polycyclic derivatives are regarded as potent mutagens and carcinogens following bioactivation to produce nitrenium electrophiles that covalently m
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::df184395c477953dde6c2a3339a4a899
https://pubmed.ncbi.nlm.nih.gov/31885260
https://pubmed.ncbi.nlm.nih.gov/31885260
Autor:
P. David Josephy, Reema Deol
Publikováno v:
Xenobiotica. 47:202-207
1. The mercapturic acid (MA) pathway is a metabolic route for the processing of glutathione conjugates to MA (N-acetylcysteine conjugates). An N-acetyltransferase enzyme, NAT8, catalyzes the transfer of an acetyl group from acetyl-CoA to the cysteine
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::83ff9bacfcc00041521a52bad0382f20
https://doi.org/10.1080/00498254.2016.1178410
https://doi.org/10.1080/00498254.2016.1178410
Autor:
Meghan Lambie, Hilary Groom, Joban Dhanoa, P. David Josephy, Muhammad Zahid, Giovanna Brondino Duarte de Souza
Publikováno v:
Environmental and Molecular Mutagenesis. 57:10-16
Genotoxicity data on commercial azo dyes and their components remain sparse, despite their widespread use. We have tested the mutagenicity of 2-cyano-4-nitroaniline (CNNA) and 2,6-dicyano-4-nitroaniline (CNCNNA), components of azo dyes such as Disper
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::48f4bbdf8e7b7a458f457e22d0dd5d14
https://doi.org/10.1002/em.21983
https://doi.org/10.1002/em.21983
Autor:
P. David Josephy, Joban Dhanoa, George Elzawy, Kayla Heney, Laurenne Petrie, Chantel Senis, G. Hoffmann
Publikováno v:
Environmental and molecular mutagenesis. 59(2)
2,6-Dicyano-4-nitroaniline and 2-cyano-4-nitroaniline (CNNA; 2-amino-5-nitrobenzonitrile) are potent mutagens in the Ames test, even though unsubstituted nitroanilines (NAs) are no more than weak mutagens. These compounds are putative reduction produ
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9bc66a80f393dd4cfb557a2f68fd15cf
https://pubmed.ncbi.nlm.nih.gov/29178210
https://pubmed.ncbi.nlm.nih.gov/29178210
Autor:
P. David Josephy, Daniel G. Cyr
Publikováno v:
Chemical Research in Toxicology. 21:1909-1912
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c1063200a0e03e7e0fa87054565cd24b
https://doi.org/10.1021/tx800295w
https://doi.org/10.1021/tx800295w
Autor:
P David, Josephy, Muhammad, Zahid, Joban, Dhanoa, Giovanna Brondino Duarte, de Souza, Hilary, Groom, Meghan, Lambie
Publikováno v:
Environmental and molecular mutagenesis. 57(1)
Genotoxicity data on commercial azo dyes and their components remain sparse, despite their widespread use. We have tested the mutagenicity of 2-cyano-4-nitroaniline (CNNA) and 2,6-dicyano-4-nitroaniline (CNCNNA), components of azo dyes such as Disper
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::d1217b99288c309d9d1519db4f16cabd
https://pubmed.ncbi.nlm.nih.gov/28714194
https://pubmed.ncbi.nlm.nih.gov/28714194
Publikováno v:
Chemical Research in Toxicology. 20:88-94
A new procedure has been developed for the extraction of 2-amino-1-methyl-6-phenyl-imidazo[4,5-b]pyridine (PhIP) and other heterocyclic aromatic amines from human breast milk samples. Extracts were analyzed by high-performance liquid chromatography/e
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::43b3db4addf28b49d3c69e0502413628
https://doi.org/10.1021/tx0601861
https://doi.org/10.1021/tx0601861