Zobrazeno 1 - 10
of 62
pro vyhledávání: '"and Nigel P. Shankley"'
Autor:
J. Michael Young, Henk Timmerman, Robin Thurmond, Holger Stark, Nigel P. Shankley, Roland Seifert, Jean-Charles Schwartz, Walter Schunack, Pertti Panula, Steve Liu, Roberto Levi, Rob Leurs, Rebecca Hills, Stephen J. Hill, Helmut L. Haas, Ralf Gutzmer, C. Robin Ganellin, Hiroyuki Fukui, Marlon Cowart, Paul Chazot
Publikováno v:
IUPHAR/BPS Guide to Pharmacology CITE. 2023
Histamine receptors (nomenclature as agreed by the NC-IUPHAR Subcommittee on Histamine Receptors [80, 174]) are activated by the endogenous ligand histamine. Marked species differences exist between histamine receptor orthologues [80]. The human and
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::5ab34122021ce28ae74c282dc7ff573b
https://doi.org/10.2218/gtopdb/f33/2023.1
https://doi.org/10.2218/gtopdb/f33/2023.1
Autor:
Nigel P. Shankley, Hiroyuki Fukui, Steve Liu, C. Robin Ganellin, Pertti Panula, Robin L. Thurmond, Roland Seifert, Stephen J. Hill, Jean-Charles Schwartz, Roberto Levi, Rob Leurs, Henk Timmerman, J. Michael Young, Ralf Gutzmer, Holger Stark, Paul L. Chazot, Rebecca Hills, Helmut L. Haas, Marlon D. Cowart, Walter Schunack
Publikováno v:
IUPHAR/BPS Guide to Pharmacology CITE. 2021
Histamine receptors (nomenclature as agreed by the NC-IUPHAR Subcommittee on Histamine Receptors [80, 173]) are activated by the endogenous ligand histamine. Marked species differences exist between histamine receptor orthologues [80]. The human and
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::e36a9ef171668170ae3aa6bcfacd20d2
https://doi.org/10.2218/gtopdb/f33/2021.3
https://doi.org/10.2218/gtopdb/f33/2021.3
Autor:
Kimon C. Kanelakis, Jayashree Pyati, Pamela C. Wagaman, Jui Chang Chuang, Young Yang, Nigel P. Shankley
Publikováno v:
Advances in Hematology, Vol 2009 (2009)
The heme-regulated inhibitor (HRI) negatively regulates protein synthesis by phosphorylating eukaryotic initiation factor-2α (eIF2α) thereby inhibiting protein translation. The importance of HRI in regulating hemoglobin synthesis in erythroid cells
Externí odkaz:
https://doaj.org/article/1550ff257a9b4840b7223c3f1e398751
Autor:
Henk Timmerman, J. Michael Young, Ralf Gutzmer, Nigel P. Shankley, Jean-Charles Schwartz, Holger Stark, Rebecca Hills, Robin L. Thurmond, Roberto Levi, Helmut L. Haas, Hiroyuki Fukui, Walter Schunack, Steve Liu, Rob Leurs, Roland Seifert, Paul L. Chazot, C. Robin Ganellin, Stephen J. Hill, Pertti Panula, Marlon D. Cowart
Publikováno v:
IUPHAR/BPS Guide to Pharmacology CITE. 2019
Histamine receptors (nomenclature as agreed by the NC-IUPHAR Subcommittee on Histamine Receptors [75, 163]) are activated by the endogenous ligand histamine. Marked species differences exist between histamine receptor orthologues [75]. The human and
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::909fa860575554046685bc146f90b913
https://doi.org/10.2218/gtopdb/f33/2019.4
https://doi.org/10.2218/gtopdb/f33/2019.4
Autor:
Judy Skaptason, Michael H. Rabinowitz, Terrance D Barrett, Theresa I. Brondstetter, Xiaodong Wu, Jingjin Gao, Heather L. Palomino, Hariharan Venkatesan, Jing Ying Ma, Wen Yan, Freddy Schoetens, Nigel P. Shankley, Katherine P Merton, Da-Thao Tran, Mark D. Rosen, Kimon C Kanelakis
Publikováno v:
British Journal of Pharmacology. 172:4078-4088
Background and Purpose Small-molecule inhibitors of prolyl hydroxylase (PHD) enzymes are a novel target for the treatment of anaemia and functional iron deficiency (FID). Other than being orally bioavailable, the differentiation of PHD inhibitors fro
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::a7198839e8209100a3172cb9f3b9fae7
https://doi.org/10.1111/bph.13188
https://doi.org/10.1111/bph.13188
Autor:
Lina Li, Jianing Di, Xiaodong Wu, Veronica Moreno, David Polidori, Lynn Yieh, Wen Yan, G. Lynis Dohm, Nigel P. Shankley, Celia P. Briscoe, Walter J. Pories
Publikováno v:
Obesity Surgery. 24:1969-1974
Changes in gastrointestinal peptide release may play an important role in improving glucose control and reducing body weight following Roux-en-Y gastric bypass (RYGB), but the impact of low caloric intake on gut peptide release post-surgery has not b
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::00bd870292c10750a89e9a9c74fcbff9
https://doi.org/10.1007/s11695-014-1316-9
https://doi.org/10.1007/s11695-014-1316-9
Autor:
P Wagaman, Michele C. Rizzolio, Magda F. Morton, L Andries, Terrance D Barrett, Nigel P. Shankley, Guy Lagaud, W Yan, JM Freedman
Publikováno v:
British Journal of Pharmacology. 166:1684-1693
BACKGROUND AND PURPOSE JNJ-26070109 [(R)4-bromo-N-[1-(2,4-difluoro-phenyl)-ethyl]-2-(quinoxaline-5-sulfonylamino)-benzamide] is a novel antagonist at cholecystokinin CCK2 receptors with good pharmacokinetic properties and represents a novel mechanism
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::05d41c3454e984aed76f96fbe7de05c7
https://doi.org/10.1111/j.1476-5381.2012.01878.x
https://doi.org/10.1111/j.1476-5381.2012.01878.x
Roux-en-Y Gastric Bypass Corrects Hyperinsulinemia Implications for the Remission of Type 2 Diabetes
Autor:
Rita C. Bowden, Timothy P. Gavin, William C. Chapman, Melissa A. Reed, G. Lynis Dohm, Hisham A. Barakat, Steven P. Piccoli, Walter J. Pories, Donghai Zheng, David Polidori, Lynn Yieh, Leona Brenner-Gati, Ed Tapscott, Nigel P. Shankley, Thomas D. Green, John R. Pender
Publikováno v:
The Journal of Clinical Endocrinology & Metabolism. 96:2525-2531
Roux-en-Y gastric bypass (RYGB) has been shown to induce rapid and durable reversal of type 2 diabetes.The aim of the study was to investigate a possible mechanism for the remission of type 2 diabetes after RYGB.A cross-sectional, nonrandomized, cont
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::43c0ba56151ff910047ed7839d96483f
https://doi.org/10.1210/jc.2011-0165
https://doi.org/10.1210/jc.2011-0165
Autor:
Young Yang, Jayashree Pyati, Kimon C. Kanelakis, Nigel P. Shankley, Pamela C. Wagaman, Jui Chang Chuang
Publikováno v:
Advances in Hematology, Vol 2009 (2009)
Advances in Hematology
Advances in Hematology
The heme-regulated inhibitor (HRI) negatively regulates protein synthesis by phosphorylating eukaryotic initiation factor-2α(eIF2α) thereby inhibiting protein translation. The importance of HRI in regulating hemoglobin synthesis in erythroid cells
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a1c809f13110a9650679665aaaea4878
https://doi.org/10.1155/2009/251915
https://doi.org/10.1155/2009/251915
Autor:
James Guy Breitenbucher, Nigel P. Shankley, Jamie M. Freedman, Terrance D. Barrett, Guy Lagaud, Wen Yan
Publikováno v:
British Journal of Pharmacology. 153:1650-1658
Background and purpose: Cholecystokinin (CCK) stimulates the release of amylase and lipase from the normal pancreas. However, it is not clear to what extent this occurs in the early stages of pancreatitis induced by biliary tract obstruction in the r
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::28bd558cadde0656f9dc0ad1f4d84816
https://doi.org/10.1038/bjp.2008.44
https://doi.org/10.1038/bjp.2008.44