Zobrazeno 1 - 10
of 12
pro vyhledávání: '"and Mohammed Bencheqroun"'
Autor:
Mickael Calosso, Yvan Guindon, Gabrielle St-Pierre, Michel Prévost, Guillaume Tambutet, Marc Vaillancourt, Jean-Philippe Gratton, Daniel Charpentier, Mohammed Bencheqroun
Publikováno v:
ACS Medicinal Chemistry Letters. 5:1054-1059
We report on the design and synthesis of molecules having E- and P-selectins blocking activity both in vitro and in vivo. The GlcNAc component of the selectin ligand sialyl Lewis(X) was replaced by an acyclic tether that links two saccharide units. T
Autor:
Yvan Guindon, Mohammed Bencheqroun, Marc Vaillancourt, Mickael Calosso, Daniel Charpentier, Brian C. Wilkes, Gabrielle St-Pierre
Publikováno v:
ACS Medicinal Chemistry Letters. 3:1045-1049
The discovery of molecules that interfere with the binding of a ligand to a receptor remains a topic of great interest in medicinal chemistry. Herein, we report that a monosaccharide unit of a polysaccharide ligand can be replaced advantageously by a
Publikováno v:
Organic Letters. 11:3148-3151
A novel strategy for the stereoselective construction of all-carbon quaternary centers on acyclic molecules using a two-step tandem process is reported. The first step involves an intramolecular and stereoselective atom transfer radical cyclization r
Autor:
Yvan Guindon, Mohammed Bencheqroun
Publikováno v:
Tetrahedron Letters. 42:6041-6044
anti Relative stereochemistry is achieved in the hydrogen-transfer reaction of a lactam adjacent to the carbon-centered radical. The sense of diastereoselectivity is reversed using N-substituted lactams, and optimal results favoring syn reduced produ
Autor:
Mohammed Bencheqroun, Yvan Guindon
Publikováno v:
ChemInform. 33
anti Relative stereochemistry is achieved in the hydrogen-transfer reaction of a lactam adjacent to the carbon-centered radical. The sense of diastereoselectivity is reversed using N-substituted lactams, and optimal results favoring syn reduced produ
Publikováno v:
ChemInform. 40
A novel strategy for the stereoselective construction of all-carbon quaternary centers on acyclic molecules using a two-step tandem process is reported. The first step involves an intramolecular and stereoselective atom transfer radical cyclization r
Publikováno v:
Journal of the American Chemical Society. 127(2)
Reported herein is a strategy employing an addition reaction in tandem with a hydrogen-transfer reaction for the elaboration of C-glycoside-based sialyl Lewis X (sLe(X)) analogues. Significant stereocontrol was noted when alkyl radicals were reacted
Autor:
Karine Houde, Brigitte Guérin, Mohammed Bencheqroun, Yvan Guindon, Michel Prévost, Benoit Daoust, Benoit Cardinal-David, Landry Serge
Publikováno v:
Journal of the American Chemical Society. 123(35)
Reported herein is a strategy employing a Mukaiyama reaction in tandem with a hydrogen transfer reaction for the elaboration of propionate motifs. The nature of the protecting groups on the chiral beta-alkoxy aldehyde and the type of Lewis acid used
Autor:
Landry Serge, Lorraine Murtagh, Valérie Caron, Yvan Guindon, † and Anne-Marie Faucher, Mohammed Bencheqroun, Brigitte Guérin, Grace Jung
Publikováno v:
The Journal of organic chemistry. 66(16)
The strategy considered herein features an iodocyclofunctionalization/hydrogen-transfer reaction sequence for the elaboration of propionate motifs. Proceeding with excellent yield and diastereoselectivity, the synthetic sequence proposed gives access
Autor:
Ghiro Elise, G. Bantle, Yvan Guindon, L. Murtagh, Abdelmalik Slassi, J. Rancourt, Mohammed Bencheqroun, Grace Jung
Publikováno v:
The Journal of Organic Chemistry. 60:288-289