Zobrazeno 1 - 10
of 89
pro vyhledávání: '"and Michael W. Lark"'
Autor:
Lloyd A. Culp, Michael W. Lark
Publikováno v:
Connective Tissue Disease ISBN: 9781003210016
Connective Tissue Disease
Connective Tissue Disease
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::605c005cbd4ba7863a49a172b31e7351
https://doi.org/10.1201/9781003210016-10
https://doi.org/10.1201/9781003210016-10
Autor:
Michael W. Lark, Aimee L. Crombie, William Gowen-MacDonald, Richard Carr, Michael Koblish, Conrad L. Cowan, Jonathan D. Violin, David H. Rominger, Edward R. Siuda
Publikováno v:
Journal of Pharmacology and Experimental Therapeutics. 362:254-262
Prescription opioids are a mainstay in the treatment of acute moderate to severe pain. However, chronic use leads to a host of adverse consequences including tolerance and opioid-induced hyperalgesia (OIH), leading to more complex treatment regimens
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::98abb335ba94d232cfe85452a2a9be04
https://doi.org/10.1124/jpet.117.241117
https://doi.org/10.1124/jpet.117.241117
Autor:
Ian E. James, David G. Soergel, Franck Skobieranda, Brian M. Sadler, Jonathan D. Violin, Lynn R. Webster, Nancy Burnham, Ruth Ann Subach, Michael W. Lark
Publikováno v:
Pain. 155:1829-1835
Opioids provide powerful analgesia but also efficacy-limiting adverse effects, including severe nausea, vomiting, and respiratory depression, by activating μ-opioid receptors. Preclinical models suggest that differential activation of signaling path
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8bad8acbffee949e42d456156c63ea90
https://doi.org/10.1016/j.pain.2014.06.011
https://doi.org/10.1016/j.pain.2014.06.011
Publikováno v:
Trends in Pharmacological Sciences. 35:308-316
Drug discovery targeting G protein-coupled receptors (GPCRs) is no longer limited to seeking agonists or antagonists to stimulate or block cellular responses associated with a particular receptor. GPCRs are now known to support a diversity of pharmac
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::84cd7183f4c98a4325db3a4a657e0d2c
https://doi.org/10.1016/j.tips.2014.04.007
https://doi.org/10.1016/j.tips.2014.04.007
Autor:
Conrad L. Cowan, Jonathan D. Violin, David G. Soergel, Brian M. Sadler, John Connell, Michael W. Lark, Alan S. Marion, Ruth Ann Subach
Publikováno v:
The Journal of Clinical Pharmacology. 54:351-357
TRV130 is a G protein-biased ligand at the µ-opioid receptor. In preclinical studies it was potently analgesic while causing less respiratory depression and gastrointestinal dysfunction than morphine, suggesting unique benefits in acute pain managem
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::a45f2a5f1240b9d28e429a95d6f234b6
https://doi.org/10.1002/jcph.207
https://doi.org/10.1002/jcph.207
Publikováno v:
The Journal of Clinical Pharmacology. 53:892-899
TRV027 is a novel β-arrestin biased peptide ligand of the angiotensin II type 1 receptor (AT1R). The compound antagonizes G protein coupling while simultaneously stimulating β-arrestin-mediated signaling. In preclinical studies, TRV027 reversibly r
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::007201a0cb553ee50a1910a60efd438f
https://doi.org/10.1002/jcph.111
https://doi.org/10.1002/jcph.111
Publikováno v:
Circulation: Heart Failure. 5:627-634
Background— TRV120027 is a novel β-arrestin biased ligand of the angiotensin II type 1 receptor; it antagonizes canonical G-protein–mediated coupling while, in contrast to classical angiotensin II type 1 receptor antagonists, it engages β-arres
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9b189d9de86a31960c427b6d378aa7eb
https://doi.org/10.1161/circheartfailure.112.969220
https://doi.org/10.1161/circheartfailure.112.969220
Publikováno v:
Drug Discovery Today: Therapeutic Strategies. 9:e149-e154
The angiotensin II type 1 receptor (AT1R) is an important drug target for hypertension and chronic heart failure. This receptor is also important in the pathophysiology of acute heart failure, stimulating both adverse and beneficial hemodynamic and r
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::6461a5f4a8bd5597540b9ae735f624df
https://doi.org/10.1016/j.ddstr.2014.01.001
https://doi.org/10.1016/j.ddstr.2014.01.001
Autor:
Dennis S. Yamashita, Michael W. Lark, Kevin Schiller, Maxine Gowen, Scott M. DeWire, Jonathan D. Violin, David H. Rominger, Erin J. Whalen, Lisa Nguyen
Publikováno v:
Journal of Pharmacology and Experimental Therapeutics. 335:572-579
Biased G protein-coupled receptor ligands engage subsets of the receptor signals normally stimulated by unbiased agonists. However, it is unclear whether ligand bias can elicit differentiated pharmacology in vivo. Here, we describe the discovery of a
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0e75a975b85639a7b0b3a0fe9410175d
https://doi.org/10.1124/jpet.110.173005
https://doi.org/10.1124/jpet.110.173005
Autor:
Michael W. Lark, Jorge O. Galante, Joshua J. Jacobs, Lori A. Hoerrner, Katalin Mikecz, Jianling Yao, Tibor T. Glant, Klaus E. Kuettner, Nancy I. Hutchinson
Publikováno v:
Journal of Bone and Mineral Research. 10:1417-1427
Periprosthetic osteolysis with or without aseptic loosening is a major clinical problem in total hip arthroplasty. While the macrophage response to prosthetic wear debris and its role in periprosthetic osteolysis has been extensively studied, informa
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::02f0e1997c60477e781914fe8779acf1
https://doi.org/10.1002/jbmr.5650100920
https://doi.org/10.1002/jbmr.5650100920