Zobrazeno 1 - 10
of 29
pro vyhledávání: '"and Melissa R. Thomas"'
Autor:
Andrew Sentoogo Ssemata, Ann Jacquelline Nakitende, Simon Kizito, Melissa R. Thomas, Sumaiya Islam, Paul Bangirana, Noeline Nakasujja, Ziyi Yang, Yunpeng Yu, Tuan M. Tran, Chandy C. John, Megan S. McHenry
Publikováno v:
Malaria Journal, Vol 22, Iss 1, Pp 1-12 (2023)
Abstract Background Malaria affects 24 million children globally, resulting in nearly 500,000 child deaths annually in low- and middle-income countries (LMICs). Recent studies have provided evidence that severe malaria infection results in sustained
Externí odkaz:
https://doaj.org/article/e255ec6addc34dd0b5e0b43aae1591da
Autor:
Kara Wools-Kaloustian, Jeremiah Laktabai, Sonak Pastakia, Laura J Ruhl, Winstone Nyandiko, Rachel C Vreeman, Michael Scanlon, Debra K Litzelman, Jepchirchir Kiplagat, Rishika O'Brien, David Plater, Melissa R Thomas, Rashmi Gopal-Srivastava, Nydia Morales-Soto
Publikováno v:
BMJ Global Health, Vol 8, Iss Suppl 7 (2023)
Externí odkaz:
https://doaj.org/article/04514f48858a43f2a64a0b80cd63a32a
Publikováno v:
Global Advances in Integrative Medicine and Health. 12:275361302311623
Physician burnout is a major problem that has long been facing our healthcare system. The COVID-19 pandemic has unfortunately deepened this problem and shed the light on the multiple structural shortcomings of our healthcare system that need immediat
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::6f4fa693ee841da2950796c2ddf5835d
https://doi.org/10.1177/27536130231162350
https://doi.org/10.1177/27536130231162350
Autor:
Richard Smith, Amy Duguay, Alice Bakker, Peng Li, Jennifer Weiszmann, Melissa R Thomas, Benjamin M Alba, Xinle Wu, Jamila Gupte, Li Yang, Jennitte Stevens, Agnes Hamburger, Stephen Smith, Jiyun Chen, Renee Komorowski, Kevin W Moore, Murielle M Véniant, Yang Li
Publikováno v:
PLoS ONE, Vol 8, Iss 4, p e61432 (2013)
The endocrine hormone FGF21 has attracted considerable interest as a potential therapeutic for treating diabetes and obesity. As an alternative to the native cytokine, we generated bispecific Avimer polypeptides that bind with high affinity and speci
Externí odkaz:
https://doaj.org/article/94370a4c5af3418bafae3672e5e4eb24
Autor:
Stefan Franzen, Eric S. Peterson, Derek Brown, Steven G. Boxer, Joel M. Friedman, Melissa R. Thomas
Publikováno v:
European Journal of Biochemistry. 269:4879-4886
Resonance Raman spectroscopy has been used to observe changes in the iron–ligand stretching frequency in photoproduct spectra of the proximal cavity mutant of myoglobin H93G. The measurements compare the deoxy ferrous state of the heme iron in H93G
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::22ea6504076f8ee5ba3b00cc2e4315b1
https://doi.org/10.1046/j.1432-1033.2002.03193.x
https://doi.org/10.1046/j.1432-1033.2002.03193.x
Publikováno v:
Biochemistry. 40:15047-15056
Nitric oxide (NO) binds to the myoglobin (Mb) cavity mutant, H93G, forming either a five- or six-coordinate Fe-NO complex. The H93G mutation eliminates the covalent attachment between the protein and the proximal ligand, allowing NO to bind H93G poss
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::be139b9c4250796199487f0bef9a3108
https://doi.org/10.1021/bi011440l
https://doi.org/10.1021/bi011440l
Autor:
Robert B. Hu, Melissa R. Thomas, R. Brian Dyer, James A. Bailey, William H. Woodruff, Steven G. Boxer, Stefan Franzen
Publikováno v:
Biochemistry. 40:5299-5305
Resonance Raman spectroscopy and step-scan Fourier transform infrared (FTIR) spectroscopy have been used to identify the ligation state of ferrous heme iron for the H93G proximal cavity mutant of myoglobin in the absence of exogenous ligand on the pr
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3285faf004f36f49c2c9a3557e88e075
https://doi.org/10.1021/bi0023403
https://doi.org/10.1021/bi0023403
Publikováno v:
Inorganic Chemistry. 39:6061-6066
One of the difficulties in preparing accurate ambient-temperature model complexes for heme proteins, particularly in the ferric state, has been the generation of mixed-ligand adducts: complexes with different ligands on either side of the heme. The d
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f29f592d31c0d97f4265b0acc175b4c4
https://doi.org/10.1021/ic0007198
https://doi.org/10.1021/ic0007198
Publikováno v:
Journal of the American Chemical Society. 122:12297-12303
The vibrational Stark effect measures the effect of an external electric field on the vibrational (IR) spectrum of a molecule. This technique gives quantitative information on the sensitivity of a vibrational peak position to an electric field. This
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::ab0f724bf11b8493aa0bbfbce66eb932
https://doi.org/10.1021/ja0014741
https://doi.org/10.1021/ja0014741
Publikováno v:
Journal of the American Chemical Society. 121:12088-12093
Recently, heme protein cavity mutants have been engineered in which the proximal coordinating amino acid has been replaced by a smaller, noncoordinating residue leaving a cavity that can be filled by exogenous axial ligands. This approach was pioneer
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::dcc6046843d32dce06359736068b4364
https://doi.org/10.1021/ja9915504
https://doi.org/10.1021/ja9915504