Zobrazeno 1 - 10
of 34
pro vyhledávání: '"and Matthew H. Lyttle"'
Publikováno v:
International Journal of Peptide Research and Therapeutics
A step-by-step evaluation of dual-labeled FRET substrates for the protease calpain is reported. The study led to cell permeable selections, with optimized specificity and effectiveness for the target enzyme, and improved stability to non-specific deg
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e24fdba19045f50ee5a84d94186d7e11
http://europepmc.org/articles/PMC7088158
http://europepmc.org/articles/PMC7088158
Publikováno v:
Bioconjugate Chemistry. 13:1155-1158
Several fluorescence resonance energy transfer (FRET) oligonucleotide probes were made with different internal linkages between the DNA and the quencher dye. In one example, a 5'-fluorescein beta-actin-based 26-mer DNA sequence was synthesized bearin
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9ed78018a516a0e87eef14ec8d9e50ac
https://doi.org/10.1021/bc0200125
https://doi.org/10.1021/bc0200125
Publikováno v:
The Journal of Organic Chemistry. 65:9033-9038
5-Carboxy Tamra 1 was conjugated to 4-hydroxypiperidine with BOP and N-methylmorpholine, and the resulting 5-(N-pipyridyl-4-hydroxy)-Tamra carboxamide 2 was treated with 2-cyanoethyl tetraisopropylphosphorodiamidite to give 5-[N-pipyridyl-4-O-(2-cyan
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::cf875832c7b80807e31dc2679822febf
https://doi.org/10.1021/jo0011134
https://doi.org/10.1021/jo0011134
Publikováno v:
Organic Process Research & Development. 5:45-49
Literature syntheses of 4,7,2‘,7‘-tetrachloro-5(and 6)-carboxy-fluorescein (“5 and 6 TET”) 1 and 4‘,5‘-dichloro-2‘,7‘-dimethoxy-5(and 6)-carboxyfluorescein (“5 and 6 JOE”) 2 are reviewed, and new, preparatively useful methods are
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::82b0e6a832b24007d7154d8dc0d56ca8
https://doi.org/10.1021/op000292o
https://doi.org/10.1021/op000292o
Publikováno v:
Nucleosides and Nucleotides. 18:1809-1824
A uridine-based linker immobilized onto polystyrene beads at the 5′ terminus via a phosphodiester group and then used as a universal DNA synthesis support gives post synthesis DNA cleavage in 8 hrs or less without alkali metal salts. DNA produced w
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::20b2a10ea36b1083e7274f6265897c5d
https://doi.org/10.1080/07328319908044845
https://doi.org/10.1080/07328319908044845
Autor:
and Matthew H. Lyttle, Michael F. Songster, J. Howard Adams, Ronald M. Cook, Vasu Jammalamadaka, Derek Hudson
Publikováno v:
The Journal of Organic Chemistry. 63:3706-3716
Mild, efficient conditions have been developed for the preparation of 4-methylbenzhydrylamine polystyrene (MBHA) and aminomethyl polystyrene (AMPS) resins by a two-step procedure with synthons 1a and 1c. The products possess excellent swelling charac
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::306c1a4bf6f3ba33ba9c824cdd26a5cc
https://doi.org/10.1021/jo9802269
https://doi.org/10.1021/jo9802269
Design, Synthesis, and Evaluation of Latent Alkylating Agents Activated by Glutathione S-Transferase
Autor:
Kim A. Kane-Maguire, Matthew H. Lyttle, Michael D. Hocker, Amy S. Morgan, Apparao Satyam, Hugo O. Villar
Publikováno v:
Journal of Medicinal Chemistry. 39:1736-1747
In search of compounds with improved specificity for targeting the important cancer-associated P1-1 glutathione S-transferase (GST) isozyme, new analogs 4 and 5 of the previously reported glutathione S-transferase (GST)-activated latent alkylating ag
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a5ef4c9646d251a1ecc65814512fd25b
https://doi.org/10.1021/jm950005k
https://doi.org/10.1021/jm950005k
Autor:
Jeffrey P. Solar, Matthew H. Lyttle, Hsu-Kun Wang, Andrew Streitwieser, Angelika Weinländer, Thomas R. Boussie
Publikováno v:
Journal of Organometallic Chemistry. 501:245-249
1,1′-Dimesityluranocene gives a 1 H NMR spectrum showing the mesityl groups in a locked position as expected with exo - and endo-ortho -methyl groups. The [8]annulene ring protons give four resonances at room temperature in a 2:2:2:1 ratio, but at
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::deeee1413b521f4cd16d16818214befa
https://doi.org/10.1016/0022-328x(95)05672-c
https://doi.org/10.1016/0022-328x(95)05672-c
Autor:
Matthew H. Lyttle
Publikováno v:
Drug Development Research. 35:230-236
Large biotechnology based initiatives, like the Human Genome Project, in addition to accelerating scientific progress and improving the understanding of basic biological process, are responsible for an increased demand for high quality drug candidate
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::e51f9b3457978752b37e537f422531da
https://doi.org/10.1002/ddr.430350404
https://doi.org/10.1002/ddr.430350404
Autor:
Matthew H. Lyttle, Karin E. Bauer, Hui Hon Chung, Apparao Satyam, Colby G. Caldwell, Michael D. Hocker, Lawrence M. Kauvar, Alemayehu Mergia, Amy S. Morgan
Publikováno v:
Journal of Medicinal Chemistry. 37:1501-1507
Alkylating agents which are activated by glutathion-S-transferases (GSTs) have been designed and synthesized. The model compound gamma-glutamyl-alpha-amino-beta-[(2-ethyl N,N,N',N'-tetraethylphosphorodiamidate) sulfonyl]propionylglycine (1) and the n
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3ca0c73c4685c8b70a998c101594dd7f
https://doi.org/10.1021/jm00036a016
https://doi.org/10.1021/jm00036a016